Reference on EC 5.6.2.1 - DNA topoisomerase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pulleyblank, D.E.; Ellison, M.J.
Purification and properties of type 1 topoisomerase from chicken erythrocytes: mechanism of eukaryotic topoisomerase action
Biochemistry
21
1155-1161
1982
Gallus gallus
Javaherian, K.; Tse, Y.C.; Vega, J.
Drosophila topoisomerase I: isolation, purification and characterization
Nucleic Acids Res.
10
6945-6955
1982
Drosophila sp. (in: flies)
Badaracco, G.; Plevani, P.; Ruyechan, W.T.; Chang, L.M.S.
Purification and characterization of yeast topoisomerase I
J. Biol. Chem.
258
2022-2026
1983
Saccharomyces cerevisiae
Riou, G.F.; Gabillot, M.; Douc-Rasy, S.; Kayser, A.; Barrois, M.
A type I DNA topoisomerase from Trypanosoma cruzi
Eur. J. Biochem.
134
479-484
1983
Trypanosoma cruzi
Martin, S.R.; McCoubrey, W.K.; McConaughy, B.L.; Young, L.S.; Been, M.D.; Brewer, B.J.; Champoux, J.J.
Multiple forms of rat liver type I topoisomerase
Methods Enzymol.
100
137-144
1983
Rattus norvegicus
Ishii, K.; Hasegawa, T.; Fujisawa, K.; Andoh, T.
Rapid purification and characterization of DNA topoisomerase I from cultured mouse mammary carcinoma FM3A cells
J. Biol. Chem.
258
12728-12732
1983
Mus musculus
Yamamoto, N.; Shishido, K.; Ogawa, H.; Sekiguchi, T.; Nosho, Y.
Partial purification and characterization of type I DNA topoisomerase from Bacillus stearothermophilus
J. Biochem.
97
811-820
1985
Geobacillus stearothermophilus
Ichishima, E.; Yoshida, T.; Habuka, N.; Takeuchi, M.; Arai, T.
Mode of action of DNA topoisomerase I from Alcaligenes sp.
Biochim. Biophys. Acta
826
81-86
1985
Alcaligenes sp.
-
Ivanov, V.A.; Melnikov, A.A.; Terpilovska, O.N.
DNA topoisomerase I from rat brain neurons
Biochim. Biophys. Acta
866
154-160
1986
Rattus norvegicus
Hyder, S.M.; Baldi, A.; Crespi, M.; Wittliff, J.L.
Rapid purification of topoisomerase I from human breast cancer cells by high-performance liquid chromatography
J. Chromatogr.
359
433-447
1986
Homo sapiens
Habuka, H.K.N.; Shishido, K.
Purification and characterization of type I DNA topoisomerase from Lentinus edodes
FEMS Microbiol. Lett.
37
169-172
1986
Lentinula edodes, Lentinula edodes FMC2
-
Lazarus, G.M.; Henrich, J.P.; Kelly, W.G.; Schmitz, S.A.; Castora, F.J.
Purification and characterization of a type I DNA topoisomerase from calf thymus mitochondria
Biochemistry
26
6195-6203
1987
Bos taurus
Shuman, S.; Moss, B.
Identification of a vaccinia virus gene encoding a type I DNA topoisomerase
Proc. Natl. Acad. Sci. USA
84
7478-7482
1987
Vaccinia virus
Shuman, S.; Golder, M.; Moss, B.
Characterization of vaccinia virus DNA topoisomerase I expressed in Escherichia coli
J. Biol. Chem.
263
16401-16407
1988
Vaccinia virus
Fukata, H.; Fukasawa, H.
Isolation and partial characterization of two distinct DNA topoisomerases from cauliflower inflorescence
J. Biochem.
91
1337-1342
1983
Brassica oleracea
Duguet, M.; Lavenot, C.; Harper, F.; Mirambeau, G.; De Recondo, A.M.
DNA topoisomerases from rat liver: physiological variations
Nucleic Acids Res.
11
1059-1075
1983
Rattus norvegicus
Goto, T.; Laipis, P.; Wang, J.C.
The purification and characterization of DNA topoisomerases I and II of the yeast Saccharomyces cerevisiae
J. Biol. Chem.
259
10422-10429
1984
Saccharomyces cerevisiae
Bogulawski, G.; Armilei, G.
A DNA topoisomerase and supercoiled DNA-specific endonuclease from Flavobacterium arborescens
J. Biotechnol.
2
149-155
1985
Microbacterium arborescens, Microbacterium arborescens NRRL B-11,022
-
Riou, G.; Douc-Rasy, S.; Kayser, A.
Inhibitors of trypanosome topoisomerases
Biochem. Soc. Trans.
14
496-499
1986
Trypanosoma cruzi, Trypanosoma equiperdum
Gellert, M.
DNA topoisomerases
Annu. Rev. Biochem.
50
879-910
1981
Anas platyrhynchos, Priestia megaterium, Bos taurus, Gallus gallus, Drosophila sp. (in: flies), Escherichia coli, Homo sapiens, Micrococcus luteus, Platyrrhini, Mus musculus, Rattus norvegicus, salmon, Echinoidea, Vaccinia virus, Xenopus laevis
Andersen, A.H.; Bendixen, C.; Westergaard, O.
DNA topoisomerases
DNA Replication in eucaryotic cells, Cold Spring Harbor Laboratory Press
587-617
1996
eukaryota, Rabbit fibroma virus, Vaccinia virus
-
Vosberg, H.P.
DNA topoisomerases: enzymes that control DNA conformation
Curr. Top. Microbiol. Immunol.
114
19-102
1985
Agrobacterium tumefaciens, Priestia megaterium, Bacteria, Bos taurus, Brassica oleracea, Drosophila sp. (in: flies), Escherichia coli, eukaryota, Avibacterium paragallinarum, Homo sapiens, Micrococcus luteus, Mus musculus, Rattus norvegicus, Salmonella enterica subsp. enterica serovar Typhimurium, Triticum aestivum, Trypanosoma cruzi, Ustilago maydis, Xenopus laevis
Kohsaka, T.
Purification and characterization of a DNA topoisomerase I from Bifidobacterium breve
Agric. Biol. Chem.
53
3357-3358
1989
Bifidobacterium breve, Bifidobacterium breve YIT4006
-
Sutcliffe, J.A.; Gootz, T.D.; Barrett, J.F.
Biochemical characteristics and physiological significance of major DNA topoisomerases
Antimicrob. Agents Chemother.
33
2027-2033
1989
Bacteria, Escherichia coli, eukaryota, Salmonella enterica subsp. enterica serovar Typhimurium
Badaracco, G.; Landsberger, N.; Benfante, R.
Purification and characterization of a proteolytic active fragment of DNA topoisomerase I from the brine shrimp, Artemia franciscana (Crustacea anostraca)
Biochem. J.
282
249-254
1992
Artemia franciscana
Suzuki, M.; Takagi, E.; Kojima, K.; Izuta, S.; Yoshida, S.
Rapid purification and structural study of DNA topoisomerase I from human Burkitt lymphoma Raji cells
J. Biochem.
106
742-744
1989
Homo sapiens
Kieber, J.J.; Lopez, M.F.; Tissier, A.F.; Signer, E.
Purification and properties of DNA topoisomerase I from broccoli
Plant Mol. Biol.
18
865-871
1992
Brassica oleracea
Knudsen, B.R.; Straub, T.; Boege, F.
Separation and functional analysis of eukaryotic DNA topoisomerases by chromatography and electrophoresis
J. Chromatogr.
684
307-321
1996
eukaryota, Homo sapiens
Ikegami, Y.; Takeuchi, N.; Hanada, M.; Hasegawa, Y.; Ishi, K.; Andoh, T.; Sato, T.; Suzuki, K.; Yamaguchi, H.; Miyazaki, S.; Nagai, K.; Watanabe, S.; Saito, T.
Topostin, a novel inhibitor of mammalian DNA topoisomerase I from Flexibacter topostinus sp. nov.. II. Purification and some properties of topostin
J. Antibiot.
43
158-162
1990
Mus musculus
Melendy, T.; Ray, D.S.
Purification and nuclear localization of a type I topoisomerase from Crithidia fasciculata
Mol. Biochem. Parasitol.
24
215-225
1987
Crithidia fasciculata
Markauskas, A.; Tiknius, V.; Marcisauskas, R.
Use of immobilized triazine dyes in the purification of DNA topoisomerase I (Topo I) and terminal deoxynucleotidyl transferase (TdT) from calf thymus
J. Chromatogr.
539
525-529
1991
Bos taurus
Tricoli, J.V.; Kowalski, D.
Topoisomerase I from chicken erythrocytes: purification, characterization, and detection by a deoxyribonucleic acid binding
Biochemistry
22
2025-2031
1983
Gallus gallus
Nabiev, I.; Chourpa, I.; Riou, J.F.; Nguyen, C.H.; Lavelle, F.; Manfait, M.
Molecular interactions of DNA-topoisomerase I and II inhibitor with DNA and topoisomerases and in ternary complexes: binding modes and biological effects for intoplicine derivatives
Biochemistry
33
9013-9023
1994
Bos taurus
Trask, D.K.; Muller, M.T.
Biochemical characterization of topoisomerase I purified from avian erythrocytes
Nucleic Acids Res.
11
2779-2800
1983
Gallus gallus
Heath-Pagliuso, S.; Cole, A.D.; Kmiec, E.B.
Purification and characterization of a type-I topoisomerase from cultured tobacco cells
Plant Physiol.
94
599-606
1990
Nicotiana tabacum
Chiatante, D.; Bryant, J.A.; Fitchett, P.
DNA topoisomerase in nuclei purified from root meristem of Pisum sativum
J. Exp. Bot.
42
813-820
1991
Pisum sativum
-
Yoshida, T.; Nakata, T.; Ichishima, E.
DNA topoisomerase I from rice: enzyme synthesis in germination, and partial purification from cultured cells
Phytochemistry
30
3885-3887
1991
Oryza sativa
Shaffer, R.; Traktman, P.
Vaccinia virus encapsidates a novel topoisomerase with the properties of a eucaryotic type I enzyme
J. Biol. Chem.
262
9309-9315
1987
Vaccinia virus
Iyer, L.; Ratain, M.J.
Clinical pharmacology of camptothecins
Cancer Chemother. Pharmacol.
42
S31-S43
1998
eukaryota
Reid, R.J.D.; Benedetti, P.; Bjornsti, M.A.
Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugs
Biochim. Biophys. Acta
1400
289-300
1998
Saccharomyces cerevisiae
Pommier, Y.; Pourquier, P.; Fan, Y.; Strumberg, D.
Mechanism of the action of eucaryotic DNA topoisomerase I and drugs targeted to the enzyme
Biochim. Biophys. Acta
1400
84-105
1998
eukaryota
-
Tse-Dinh, Y.C.
Bacterial and archeal type I topoisomerases
Biochim. Biophys. Acta
1400
19-27
1998
Archaea
Chino, M.; Nishikawa, K.; Yamada, A.; Ohsone, M.; Sawa, T.; Hanaoka, F.; Ishizuka, M.; Takeuchi, T.
Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth
J. Antibiot.
51
480-486
1998
Homo sapiens
Moreau, P.; Anizon, F.; Sancelme, M.; Prudhomme, M.; Bailley, C.; Carrasco, C.; Ollier, M.; Severe, D.; Riou, J.F.; Fabbro, D.; Meyer, T.; Aubertin, A.M.
Synthesis and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle
J. Med. Chem.
41
1631-1640
1998
eukaryota
Bodley, A.L.; Cumming, J.N.; Shapiro, T.A.
Effects of camptothecin, a topoisomerase I inhibitor, on Plasmodium falciparum
Biochem. Pharmacol.
55
709-711
1998
Plasmodium falciparum
Guichard, S.; Hennebelle, I.; Bugat, R.; Canal, P.
Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in human colorectal carcinoma cell line
Biochem. Pharmacol.
55
667-676
1998
Homo sapiens
Zhang, R.; Li, Y.; Cai, Q.; Liu, T.; Sun, H.; Chambless, B.
Preclinical pharmacology of the natural product anticancer agent 10-hydroxycamptothecin, an inhibitor of topoisomerase I
Cancer Chemother. Pharmacol.
41
257-267
1989
Rattus norvegicus
Minagawa, Y.; Kigawa, J.; Irie, T.; Kanamori, Y.; Itamochi, H.; Cheng, X.; Terakawa, N.
Enhanced topoisomerase I activity and increased topoisomerase II alpha content in cisplatin-resistant cancer cell lines
Jpn. J. Cancer Res.
88
1218-1223
1997
eukaryota, Mammalia
Bailly, C; Colson, P.; Houssier, C.; Rodrigues-Pereira, E.; Prudhomme, M.; Waring, M.J.
Recognition of specific sequences in DNA by a topoisomerase I inhibitor derived from the antitumor drug rebeccamycin
Mol. Pharmacol.
53
77-87
1998
eukaryota
Chabot, G.G.
Clinical pharmacokinetics of irinotecan
Clin. Pharmacokinet.
33
245-259
1997
Mammalia
Deady, L.W.; Kaye, A.J.; Finlay, G.J.; Baguley, B.C.; Denny, W.A.
Synthesis and antitumor properties of N-[2-(dimethylamino)ethyl]carboxamide derivatives of fused tetracyclic quinolines and quinoxalines: a new class of putative topoisomerase inhibitors
J. Med. Chem.
40
2040-2046
1997
Homo sapiens, Mus musculus
Spicer, J.A.; Gamage, S.A.; Atwell, G.J.; Finlay, G.J.; Baguley, B.C.; Denny, W.A.
Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-dimethylamino)ethyl]acridine-4-carboxamide
J. Med. Chem.
40
1919-1929
1997
Homo sapiens
Yang, F.; Lu, G.; Rubin, H.
Cloning, expression, purification and characterization of DNA topoisomerase I of Mycobacterium tuberculosis
Gene
178
63-69
1996
Mycobacterium tuberculosis, Mycobacterium tuberculosis Erdman
Cummings, J.; Meikle, I.; Macpherson, J.S.; Smyth, J.F.
Determination of the novel topoisomerase I inhibitor/NU/ICRF 505 and its major metabolite in plasma, tissue and tumor by high-performance liquid chromatography
J. Chromatogr.
685
159-164
1996
eukaryota
Rodriguez-Campos, A.; Azorin, F.; Portugal, J.
Influence of elsamicin A on the activity of mammalian topoisomerase I
Biochemistry
35
11177-11182
1996
Mammalia
Wang, H.K.; Bastow, K.F.; Cosentino, L.M.; Lee, K.H.
Antitumor agents, 166. Synthesis and biological evaluation of 5,6,7,8-substituted-2-phenylthiochromen-4-ones
J. Med. Chem.
39
1975-1980
1996
eukaryota
Lanza, A.; Tornaletti, S.; Rodolfo, C.; Scanavini, M.C.; Pedrini, A.M.
Human DNA topoisomerase I-mediated cleavages stimulated by ultraviolet light-induced DNA damage
J. Biol. Chem.
271
6978-6986
1996
Homo sapiens
Fostel, J.; Montgomery, D.
Identification of the aminocatechol A-3253 as an in vitro poison of DNA topoisomerase I from Candida albicans
Antimicrob. Agents Chemother.
39
586-592
1995
Candida albicans, Homo sapiens
Markauskas, A.; Tiknius, V.; Marcisauskas, R.
Use of immobilized triazine dyes in purification of DNA topoisomerase I and terminal deoxynucleotidyl transferase from calf thymus
Eksp. Biol.
4
58-62
1990
Bos taurus
-
Bugreev, D.V.; Vasyutina, E.L.; Ryabinin, V.A.; Sinyakov, A.N.; Buneva, V.N.; Nevinsky, G.A.
Inhibition of human DNA topoisomerase I by new DNA minor groove ligands: derivatives of oligo-1,3-thiazolecarboxamides
Antisense Nucleic Acid Drug Dev.
11
137-147
2001
Homo sapiens
Alkorta, I.; Park, C.; Kong, J.; Garbisu, C.; Alberti, M.; Pon, N.; Hearst, J.E.
Rhodobacter capsulatus DNA topoisomerase I purification and characterization
Arch. Biochem. Biophys.
362
123-130
1999
Rhodobacter capsulatus
Michishita, E.; Nakabayashi, K.; Ogino, H.; Suzuki, T.; Fujii, M.; Ayusawa, D.
DNA topoisomerase inhibitors induce reversible senescence in normal human fibroblasts
Biochem. Biophys. Res. Commun.
253
667-671
1998
Homo sapiens
Argaman, M.; Bendetz-Nezer, S.; Matlis, S.; Segal, S.; Priel, E.
Revealing the mode of action of DNA topoisomerase I and its inhibitors by atomic force microscopy
Biochem. Biophys. Res. Commun.
301
789-797
2003
Bos taurus
Mizushina, Y.; Iida, A.; Ohta, K.; Sugawara, F.; Sakaguchi, K.
Novel triterpenoids inhibit both DNA polymerase and DNA topoisomerase
Biochem. J.
350
757-763
2000
Homo sapiens
-
Ting, C.Y.; Hsu, C.T.; Hsu, H.T.; Su, J.S.; Chen, T.Y.; Tarn, W.Y.; Kuo, Y.H.; Whang-Peng, J.; Liu, L.F.; Hwang, J.
Isodiospyrin as a novel human DNA topoisomerase I inhibitor
Biochem. Pharmacol.
66
1981-1991
2003
Homo sapiens
Park, H.J.; Lee, H.J.; Lee, E.J.; Hwang, H.J.; Shin, S.H.; Suh, M.E.; Kim, C.; Kim, H.J.; Seo, E.K.; Lee, S.K.
Cytotoxicity and DNA topoisomerase inhibitory activity of benz[f]indole-4,9-dione analogs
Biosci. Biotechnol. Biochem.
67
1944-1949
2003
Homo sapiens
Meng, L.H.; Liao, Z.Y.; Pommier, Y.
Non-camptothecin DNA topoisomerase I inhibitors in cancer therapy
Curr. Top. Med. Chem.
3
305-320
2003
Homo sapiens
Hotoda, N.; Hanai, R.
Characterization of recombinant human DNA topoisomerase IIIalpha activity expressed in yeast
J. Biochem.
127
1109-1113
2000
Homo sapiens
Fertala, J.; Vance, J.R.; Pourquier, P.; Pommier, Y.; Bjornsti, M.A.
Substitutions of Asn-726 in the active site of yeast DNA topoisomerase I define novel mechanisms of stabilizing the covalent enzyme-DNA intermediate
J. Biol. Chem.
275
15246-15253
2000
Saccharomyces cerevisiae
Fleury, F.; Sukhanova, A.; Ianoul, A.; Devy, J.; Kudelina, I.; Duval, O.; Alix, A.J.; Jardillier, J.C.; Nabiev, I.
Molecular determinants of site-specific inhibition of human DNA topoisomerase I by fagaronine and ethoxidine. Relation to DNA binding
J. Biol. Chem.
275
3501-3509
2000
Homo sapiens
Krogh, B.O.; Shuman, S.
Vaccinia topoisomerase mutants illuminate conformational changes during closure of the protein clamp and assembly of a functional active site
J. Biol. Chem.
276
36091-36099
2001
Vaccinia virus
Perry, K.; Mondragon, A.
Biochemical characterization of an invariant histidine involved in Escherichia coli DNA topoisomerase I catalysis
J. Biol. Chem.
277
13237-13245
2002
Escherichia coli
Belova, G.I.; Prasad, R.; Nazimov, I.V.; Wilson, S.H.; Slesarev, A.I.
The domain organization and properties of individual domains of DNA topoisomerase V, a type 1B topoisomerase with DNA repair activities
J. Biol. Chem.
277
4959-4965
2002
Methanopyrus kandleri
Villa, H.; Otero Marcos, A.R.; Reguera, R.M.; Balana-Fouce, R.; Garcia-Estrada, C.; Perez-Pertejo, Y.; Tekwani, B.L.; Myler, P.J.; Stuart, K.D.; Bjornsti, M.A.; Ordonez, D.
A novel active DNA topoisomerase I in Leishmania donovani
J. Biol. Chem.
278
3521-3526
2003
Leishmania donovani (Q8WQM6), Leishmania donovani
Cheng, B.; Feng, J.; Gadgil, S.; Tse-Dinh, Y.C.
Flexibility at Gly-194 is required for DNA cleavage and relaxation activity of Escherichia coli DNA topoisomerase I
J. Biol. Chem.
279
8648-8654
2004
Escherichia coli
Rudolph, J.; Theis, H.; Hanke, R.; Endermann, R.; Johannsen, L.; Geschke, F.U.
seco-Cyclothialidines: new concise synthesis, inhibitory activity toward bacterial and human DNA topoisomerases, and antibacterial properties
J. Med. Chem.
44
619-626
2001
Bos taurus, Escherichia coli, Homo sapiens
Zhu, C.X.; Tse-Dinh, Y.C.
Overexpression and purification of bacterial DNA topoisomerase I
Methods Mol. Biol.
94
145-152
1999
Escherichia coli
Holden, J.A.
Purification of DNA topoisomerase I from human placenta
Methods Mol. Biol.
94
213-222
1999
Homo sapiens
Feinberg, H.; Lima, C.D.; Mondragon, A.
Conformational changes in E. coli DNA topoisomerase I
Nat. Struct. Biol.
6
918-922
1999
Escherichia coli (P06612), Escherichia coli
Changela, A.; DiGate, R.J.; Mondragon, A.
Crystal structure of a complex of a type IA DNA topoisomerase with a single-stranded DNA molecule
Nature
411
1077-1081
2001
Escherichia coli
Goulaouic, H.; Roulon, T.; Flamand, O.; Grondard, L.; Lavelle, F.; Riou, J.F.
Purification and characterization of human DNA topoisomerase IIIalpha
Nucleic Acids Res.
27
2443-2450
1999
Homo sapiens
Kim, Y.C.; Lee, J.; Koo, H.S.
Functional characterization of Caenorhabditis elegans DNA topoisomerase IIIalpha
Nucleic Acids Res.
28
2012-2017
2000
Caenorhabditis elegans (O61660), Caenorhabditis elegans
Belova, G.I.; Prasad, R.; Kozyavkin, S.A.; Lake, J.A.; Wilson, S.H.; Slesarev, A.I.
A type IB topoisomerase with DNA repair activities
Proc. Natl. Acad. Sci. USA
98
6015-6020
2001
Methanopyrus kandleri
Perry, K.; Mondragon, A.
Structure of a complex between E. coli DNA topoisomerase I and single-stranded DNA
Structure
11
1349-1358
2003
Escherichia coli
Mondragon, A.; DiGate, R.
The structure of Escherichia coli DNA topoisomerase III
Structure
7
1373-1383
1999
Escherichia coli
Suzuki, T.; Uchida-Toita, M.; Andoh, T.; Yoshida, M.
HTLV-1 tax oncoprotein binds to DNA topoisomerase I and inhibits its catalytic activity
Virology
270
291-298
2000
Homo sapiens
Marquis, J.F.; Hardy, I.; Olivier, M.
Topoisomerase I amino acid substitutions, Gly185Arg and Asp325Glu, confer camptothecin resistance in Leishmania donovani
Antimicrob. Agents Chemother.
49
1441-1446
2005
Leishmania donovani
Kwon, K.; Nagarajan, R.; Stivers, J.T.
Ribonuclease activity of vaccinia DNA topoisomerase IB: kinetic and high-throughput inhibition studies using a robust continuous fluorescence assay
Biochemistry
43
14994-15004
2004
Vaccinia virus
Nagarajan, R.; Kwon, K.; Nawrot, B.; Stec, W.J.; Stivers, J.T.
Catalytic phosphoryl interactions of topoisomerase IB
Biochemistry
44
11476-11485
2005
Vaccinia virus
Cossard, R.; Viard, T.; Lamour, V.; Duguet, M.; Bouthier de La Tour, C.
Proteolytic cleavage of the hyperthermophilic topoisomerase I from Thermotoga maritima does not impair its enzymatic properties
Biochim. Biophys. Acta
1700
161-170
2004
Thermotoga maritima
Rahier, N.J.; Eisenhauer, B.M.; Gao, R.; Thomas, S.J.; Hecht, S.M.
On the role of E-ring oxygen atoms in the binding of camptothecin to the topoisomerase I-DNA covalent binary complex
Bioorg. Med. Chem.
13
1381-1386
2005
Homo sapiens
Chillemi, G.; Redinbo, M.; Bruselles, A.; Desideri, A.
Role of the linker domain and the 203-214 N-terminal residues in the human topoisomerase I DNA complex dynamics
Biophys. J.
87
4087-4097
2004
Homo sapiens
Das, B.B.; Sen, N.; Ganguly, A.; Majumder, H.K.
Reconstitution and functional characterization of the unusual bi-subunit type I DNA topoisomerase from Leishmania donovani
FEBS Lett.
565
81-88
2004
Leishmania donovani
Stagos, D.; Kazantzoglou, G.; Magiatis, P.; Mitaku, S.; Anagnostopoulos, K.; Kouretas, D.
Effects of plant phenolics and grape extracts from Greek varieties of Vitis vinifera on mitomycin C and topoisomerase I-induced nicking of DNA
Int. J. Mol. Med.
15
1013-1022
2005
Triticum aestivum
Gao, R.; Zhang, Y.; Choudhury, A.K.; Dedkova, L.M.; Hecht, S.M.
Analogues of vaccinia virus DNA topoisomerase I modified at the active site tyrosine
J. Am. Chem. Soc.
127
3321-3331
2005
Vaccinia virus
Daroui, P.; Desai, S.D.; Li, T.K.; Liu, A.A.; Liu, L.F.
Hydrogen peroxide induces topoisomerase I-mediated DNA damage and cell death
J. Biol. Chem.
279
14587-14594
2004
Saccharomyces cerevisiae
Interthal, H.; Quigley, P.M.; Hol, W.G.; Champoux, J.J.
The role of lysine 532 in the catalytic mechanism of human topoisomerase I
J. Biol. Chem.
279
2984-2992
2004
Homo sapiens (P11387), Homo sapiens
Colley, W.C.; van der Merwe, M.; Vance, J.R.; Burgin, A.B., Jr.; Bjornsti, M.A.
Substitution of conserved residues within the active site alters the cleavage religation equilibrium of DNA topoisomerase I
J. Biol. Chem.
279
54069-54078
2004
Saccharomyces cerevisiae
Cheng, B.; Shukla, S.; Vasunilashorn, S.; Mukhopadhyay, S.; Tse-Dinh, Y.C.
Bacterial cell killing mediated by topoisomerase I DNA cleavage activity
J. Biol. Chem.
280
38489-38495
2005
Yersinia pestis
Plaschkes, I.; Silverman, F.W.; Priel, E.
DNA topoisomerase I in the mouse central nervous system: Age and sex dependence
J. Comp. Neurol.
493
357-369
2005
Mus musculus
Frohlich, R.F.; Andersen, F.F.; Westergaard, O.; Andersen, A.H.; Knudsen, B.R.
Regions within the N-terminal domain of human topoisomerase I exert important functions during strand rotation and DNA binding
J. Mol. Biol.
336
93-103
2004
Homo sapiens
Chrencik, J.E.; Staker, B.L.; Burgin, A.B.; Pourquier, P.; Pommier, Y.; Stewart, L.; Redinbo, M.R.
Mechanisms of camptothecin resistance by human topoisomerase I mutations
J. Mol. Biol.
339
773-784
2004
Homo sapiens (P11387), Homo sapiens
Kamau, E.; Grove, A.
Fluoroquinolone-dependent DNA supercoiling by Vaccinia topoisomerase I
J. Mol. Biol.
342
479-487
2004
Vaccinia virus
Bakshi, R.P.; Shapiro, T.A.
RNA interference of Trypanosoma brucei topoisomerase IB: both subunits are essential
Mol. Biochem. Parasitol.
136
249-255
2004
Trypanosoma brucei
Mialon, A.; Sankinen, M.; Soderstrom, H.; Junttila, T.T.; Holmstrom, T.; Koivusalo, R.; Papageorgiou, A.C.; Johnson, R.S.; Hietanen, S.; Elenius, K.; Westermarck, J.
DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation
Mol. Cell. Biol.
25
5040-5051
2005
Homo sapiens
Chen, A.Y.; Shih, S.J.; Hsiao, M.; Rothenberg, M.L.; Prudhomme, M.
Induction of radiosensitization by indolocarbazole derivatives: the role of DNA topoisomerase I
Mol. Pharmacol.
66
553-560
2004
Homo sapiens
Li, Z.; Hiasa, H.; DiGate, R.
Bacillus cereus DNA topoisomerase I and IIIalpha: purification, characterization and complementation of Escherichia coli TopoIII activity
Nucleic Acids Res.
33
5415-5425
2005
Bacillus cereus
Di Felice, F.; Cioci, F.; Camilloni, G.
FOB1 affects DNA topoisomerase I in vivo cleavages in the enhancer region of the Saccharomyces cerevisiae ribosomal DNA locus
Nucleic Acids Res.
33
6327-6337
2005
Saccharomyces cerevisiae
Bao, K.; Cohen, S.N.
Reverse transcriptase activity innate to DNA polymerase I and DNA topoisomerase I proteins of Streptomyces telomere complex
Proc. Natl. Acad. Sci. USA
101
14361-14366
2004
Streptomyces coelicolor, Streptomyces coelicolor M145
Tian, L.; Claeboe, C.D.; Hecht, S.M.; Shuman, S.
Remote phosphate contacts trigger assembly of the active site of DNA topoisomerase IB
Structure
12
31-40
2004
Vaccinia virus
Alpan, A.S.; Gunes, H.S.; Topcu, Z.
1H-Benzimidazole derivatives as mammalian DNA topoisomerase I inhibitors
Acta Biochim. Pol.
54
561-565
2007
Mammalia
Soe, K.; Hartung, S.; Grosse, F.
Human topoisomerase I forms double cleavage complexes on natural DNA
Biochem. Biophys. Res. Commun.
349
178-185
2006
Homo sapiens
Bosedasgupta, S.; Das, B.B.; Sengupta, S.; Ganguly, A.; Roy, A.; Tripathi, G.; Majumder, H.K.
Amino acids 39-456 of large subunit and 210-262 of small subunit constitute the minimal, functionally interacting fragments of the unusual heterodimeric topoisomerase IB of Leishmania
Biochem. J.
409
481 - 489
2008
Leishmania sp.
Roy, A.; Das, B.B.; Ganguly, A.; Bosedasgupta, S.; Khalkho, N.V.; Pal, C.; Dey, S.; Giri, V.S.; Jaisankar, P.; Dey, S.; Majumder, H.K.
An insight into the mechanism of inhibition of unusual bi-subunit topoisomerase I from Leishmania donovani by 3,3-diindolylmethane, a novel DNA topoisomerase I poison with a strong binding affinity to enzyme
Biochem. J.
409
611-622
2008
Leishmania donovani
Di Felice, F.; Chiani, F.; Camilloni, G.
Nucleosomes represent a physical barrier for cleavage activity of DNA topoisomerase I in vivo
Biochem. J.
409
651-656
2008
Saccharomyces cerevisiae
Gao, R.; Zhang, Y.; Dedkova, L.; Choudhury, A.K.; Rahier, N.J.; Hecht, S.M.
Effects of modification of the active site tyrosine of human DNA topoisomerase I
Biochemistry
45
8402-8410
2006
Homo sapiens
Nagarajan, R.; Stivers, J.T.
Unmasking Anticooperative DNA-binding interactions of vaccinia DNA topoisomerase I
Biochemistry
46
192-199
2007
Vaccinia virus
Reguera, R.M.; Redondo, C.M.; Gutierrez de Prado, R.; Perez-Pertejo, Y.; Balana-Fouce, R.
DNA topoisomerase I from parasitic protozoa: a potential target for chemotherapy
Biochim. Biophys. Acta
1759
117-131
2006
Homo sapiens, Leishmania donovani, Leishmania major, Mammalia, Plasmodium falciparum, Trypanosoma congolense, Trypanosoma cruzi, Trypanosoma brucei (Q581U8)
Diaz Gonzalez, R.; Perez Pertejo, Y.; Redondo, C.M.; Pommier, Y.; Balana-Fouce, R.; Reguera, R.M.
Structural insights on the small subunit of DNA topoisomerase I from the unicellular parasite Leishmania donovani
Biochimie
89
1517-1527
2007
Leishmania donovani
Christmann-Franck, S.; Fermandjian, S.; Mirambeau, G.; Der Garabedian, P.A.
Molecular modelling studies on the interactions of human DNA topoisomerase IB with pyridoxal-compounds
Biochimie
89
468-473
2007
Homo sapiens (P11387), Homo sapiens
Basnet, A.; Thapa, P.; Karki, R.; Na, Y.; Jahng, Y.; Jeong, B.S.; Jeong, T.C.; Lee, C.S.; Lee, E.S.
2,4,6-Trisubstituted pyridines: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship
Bioorg. Med. Chem.
15
4351-4359
2007
Homo sapiens
Qin, Y.; Pang, J.Y.; Chen, W.H.; Zhao, Z.Z.; Liu, L.; Jiang, Z.H.
Inhibition of DNA topoisomerase I by natural and synthetic mono- and dimeric protoberberine alkaloids
Chem. Biodivers.
4
481-487
2007
Homo sapiens
Lebedeva, N.; Auffret Vander Kemp, P.; Bjornsti, M.A.; Lavrik, O.; Boiteux, S.
Trapping of DNA topoisomerase I on nick-containing DNA in cell free extracts of Saccharomyces cerevisiae
DNA Repair
5
799-809
2006
Saccharomyces cerevisiae
Das, B.B.; Bose Dasgupta, S.; Ganguly, A.; Mazumder, S.; Roy, A.; Majumder, H.K.
Leishmania donovani bisubunit topoisomerase I gene fusion leads to an active enzyme with conserved type IB enzyme function
FEBS J.
274
150-163
2007
Leishmania donovani
Crisona, N.J.; Cozzarelli, N.R.
Alteration of Escherichia coli topoisomerase IV conformation upon enzyme binding to positively supercoiled DNA
J. Biol. Chem.
281
18927-18932
2006
Escherichia coli
van der Merwe, M.; Bjornsti, M.A.
Mutation of GLY721 alters DNA topoisomerase I active site architecture and sensitivity to camptothecin
J. Biol. Chem.
283
3305-3315
2007
Saccharomyces cerevisiae
Nagarajan, M.; Morrell, A.; Antony, S.; Kohlhagen, G.; Agama, K.; Pommier, Y.; Ragazzon, P.A.; Garbett, N.C.; Chaires, J.B.; Hollingshead, M.; Cushman, M.
Synthesis and biological evaluation of bisindenoisoquinolines as topoisomerase I inhibitors
J. Med. Chem.
49
5129-5140
2006
Homo sapiens (P11387), Homo sapiens
Nagarajan, M.; Morrell, A.; Ioanoviciu, A.; Antony, S.; Kohlhagen, G.; Agama, K.; Hollingshead, M.; Pommier, Y.; Cushman, M.
Synthesis and evaluation of indenoisoquinoline topoisomerase I inhibitors substituted with nitrogen heterocycles
J. Med. Chem.
49
6283-6289
2006
Homo sapiens
Chaudhuri, P.; Majumder, H.K.; Bhattacharya, S.
Synthesis, DNA binding, and Leishmania topoisomerase inhibition activities of a novel series of anthra[1,2-d]imidazole-6,11-dione derivatives
J. Med. Chem.
50
2536-2540
2007
Leishmania donovani
Hede, M.S.; Petersen, R.L.; Froehlich, R.F.; Krueger, D.; Andersen, F.F.; Andersen, A.H.; Knudsen, B.R.
Resolution of Holliday junction substrates by human topoisomerase I
J. Mol. Biol.
365
1076-1092
2007
Homo sapiens
Khan, Q.A.; Pilch, D.S.
Topoisomerase I-mediated DNA cleavage induced by the minor groove-directed binding of bibenzimidazoles to a distal site
J. Mol. Biol.
365
561-569
2007
Homo sapiens
Changela, A.; DiGate, R.J.; Mondragon, A.
Structural studies of E. coli topoisomerase III-DNA complexes reveal a novel type IA topoisomerase-DNA conformational intermediate
J. Mol. Biol.
368
105-118
2007
Escherichia coli (P14294), Escherichia coli
Benarroch, D.; Claverie, J.; Raoult, D.; Shuman, S.
Characterization of mimivirus DNA topoisomerase IB suggests horizontal gene transfer between eukaryal viruses and bacteria
J. Virol.
80
314-321
2006
Acanthamoeba polyphaga Mimivirus
Hu, Y.; Clower, R.V.; Melendy, T.
Cellular topoisomerase I modulates origin binding by bovine papillomavirus type 1 E1
J. Virol.
80
4363-4371
2006
Homo sapiens
Osheroff, N.
Unraveling the structure of the variola topoisomerase IB-DNA complex: a possible new twist on smallpox therapy
Mol. Interv.
6
245-248
2006
Variola virus
Li, Z.; Hiasa, H.; DiGate, R.
Characterization of a unique type IA topoisomerase in Bacillus cereus
Mol. Microbiol.
60
140-151
2006
Bacillus cereus (Q81IH1), Bacillus cereus, Bacillus cereus ATCC 14579 (Q81IH1)
Bond, A.; Reichert, Z.; Stivers, J.T.
Novel and specific inhibitors of a poxvirus type I topoisomerase
Mol. Pharmacol.
69
547-557
2006
Homo sapiens, Vaccinia virus
Koster, D.A.; Palle, K.; Bot, E.S.; Bjornsti, M.A.; Dekker, N.H.
Antitumour drugs impede DNA uncoiling by topoisomerase I
Nature
448
213-217
2007
Homo sapiens
Das, B.B.; Sen, N.; Roy, A.; Dasgupta, S.B.; Ganguly, A.; Mohanta, B.C.; Dinda, B.; Majumder, H.K.
Differential induction of Leishmania donovani bi-subunit topoisomerase I-DNA cleavage complex by selected flavones and camptothecin: activity of flavones against camptothecin-resistant topoisomerase I
Nucleic Acids Res.
34
1121-1132
2006
Leishmania donovani
Strahs, D.; Zhu, C.X.; Cheng, B.; Chen, J.; Tse-Dinh, Y.C.
Experimental and computational investigations of Ser10 and Lys13 in the binding and cleavage of DNA substrates by Escherichia coli DNA topoisomerase I
Nucleic Acids Res.
34
1785-1797
2006
Escherichia coli
Fiorani, P.; Chillemi, G.; Losasso, C.; Castelli, S.; Desideri, A.
The different cleavage DNA sequence specificity explains the camptothecin resistance of the human topoisomerase I Glu418Lys mutant
Nucleic Acids Res.
34
5093-5100
2006
Homo sapiens
Rockstroh, A.; Kleinert, A.; Kramer, M.; Grosse, F.; Soe, K.
Cellular stress triggers the human topoisomerase I damage response independently of DNA damage in a p53 controlled manner
Oncogene
26
123-131
2007
Homo sapiens
Yang, F.; Nakajima, Y.; Kumagai, M.; Ohmiya, Y.; Ikeda, M.
The molecular mechanism regulating the autonomous circadian expression of Topoisomerase I in NIH3T3 cells
Biochem. Biophys. Res. Commun.
380
22-27
2009
Mus musculus (Q04750), Mus musculus
Laco, G.S.; Pommier, Y.
Role of a tryptophan anchor in human topoisomerase I structure, function and inhibition
Biochem. J.
411
523-530
2008
Homo sapiens (P11387), Homo sapiens
Zhang, H.; Pommier, Y.
Mitochondrial topoisomerase I sites in the regulatory D-loop region of mitochondrial DNA
Biochemistry
47
11196-11203
2008
Homo sapiens (Q969P6), Homo sapiens
Froehlich, R.F.; Juul, S.; Nielsen, M.B.; Vinther, M.; Veigaard, C.; Hede, M.S.; Andersen, F.F.
Identification of a minimal functional linker in human topoisomerase I by domain swapping with Cre recombinase
Biochemistry
47
7127-7136
2008
Homo sapiens
Khopde, S.; Roy, R.; Simmons, D.T.
The binding of topoisomerase I to T antigen enhances the synthesis of RNA-DNA primers during simian virus 40 DNA replication
Biochemistry
47
9653-9660
2008
Homo sapiens (P11387), Homo sapiens
Zhai, B.; Shuai, L.; Yang, L.; Weng, X.; Wu, L.; Wang, S.; Tian, T.; Wu, X.; Zhou, X.; Zheng, C.
Octa-substituted anionic porphyrins: topoisomerase I inhibition and tumor cell apoptosis induction
Bioconjug. Chem.
19
1535-1542
2008
Homo sapiens
Cheng, Y.; An, L.K.; Wu, N.; Wang, X.D.; Bu, X.Z.; Huang, Z.S.; Gu, L.Q.
Synthesis, cytotoxic activities and structure-activity relationships of topoisomerase I inhibitors: indolizinoquinoline-5,12-dione derivatives
Bioorg. Med. Chem.
16
4617-4625
2008
Homo sapiens
Dallavalle, S.; Gattinoni, S.; Mazzini, S.; Scaglioni, L.; Merlini, L.; Tinelli, S.; Beretta, G.L.; Zunino, F.
Synthesis and cytotoxic activity of a new series of topoisomerase I inhibitors
Bioorg. Med. Chem. Lett.
18
1484-1489
2008
Homo sapiens
Li, Z.; Zhai, F.; Zhao, L.; Guo, Q.; You, Q.
Design and synthesis of N-methylmaleimide indolocarbazole bearing modified 2-acetamino acid moieties as Topoisomerase I inhibitors
Bioorg. Med. Chem. Lett.
19
406-409
2009
Homo sapiens
Dezhenkova, L.G.; Susova, O.Y.; Shchekotikhin, A.E.; Preobrazhenskaya, M.N.; Shtil, A.A.
Naphtho[2,3-f]indole-5,10-dione aminoalkyl derivatives: a new class of topoisomerase I inhibitors
Bull. Exp. Biol. Med.
145
334-337
2008
Homo sapiens
Moulder, S.; Valkov, N.; Neuger, A.; Choi, J.; Lee, J.H.; Minton, S.; Munster, P.; Gump, J.; Lacevic, M.; Lush, R.; Sullivan, D.
Phase 2 study of gemcitabine and irinotecan in metastatic breast cancer with correlatives to determine topoisomerase I localization as a predictor of response
Cancer
113
2646-2654
2008
Homo sapiens
Ambrosini, G.; Seelman, S.L.; Qin, L.X.; Schwartz, G.K.
The cyclin-dependent kinase inhibitor flavopiridol potentiates the effects of topoisomerase I poisons by suppressing Rad51 expression in a p53-dependent manner
Cancer Res.
68
2312-2320
2008
Homo sapiens
Goswami, A.; Qiu, S.; Dexheimer, T.S.; Ranganathan, P.; Burikhanov, R.; Pommier, Y.; Rangnekar, V.M.
Par-4 binds to topoisomerase 1 and attenuates its DNA relaxation activity
Cancer Res.
68
6190-6198
2008
Homo sapiens, Mus musculus
Cheng, X.; Wang, D.; Jiang, L.; Yang, D.
DNA topoisomerase I inhibitory alkaloids from Corydalis saxicola
Chem. Biodivers.
5
1335-1344
2008
Homo sapiens
Han, H.J.; Tan, N.H.; Zeng, G.Z.; Fan, J.T.; Huang, H.Q.; Ji, C.J.; Jia, R.R.; Zhao, Q.S.; Zhang, Y.J.; Hao, X.J.; Wang, L.Q.
Natural inhibitors of DNA topoisomerase I with cytotoxicities
Chem. Biodivers.
5
1364-1368
2008
Homo sapiens
Beretta, G.L.; Perego, P.; Zunino, F.
Targeting topoisomerase I: molecular mechanisms and cellular determinants of response to topoisomerase I inhibitors
Expert Opin. Ther. Targets
12
1243-1256
2008
Homo sapiens
Lopez-Lazaro, M.; Willmore, E.; Elliott, S.L.; Austin, C.A.
Selenite induces topoisomerase I and II-DNA complexes in K562 leukemia cells
Int. J. Cancer
123
2217-2221
2008
Homo sapiens
Lebedeva, N.; Rechkunova, N.; Boiteux, S.; Lavrik, O.
Trapping of human DNA topoisomerase I by DNA structures mimicking intermediates of DNA repair
IUBMB Life
60
130-134
2008
Homo sapiens
Hackbarth, J.S.; Galvez-Peralta, M.; Dai, N.T.; Loegering, D.A.; Peterson, K.L.; Meng, X.W.; Karnitz, L.M.; Kaufmann, S.H.
Mitotic phosphorylation stimulates DNA relaxation activity of human topoisomerase I
J. Biol. Chem.
283
16711-16722
2008
Homo sapiens
Sordet, O.; Goldman, A.; Redon, C.; Solier, S.; Rao, V.A.; Pommier, Y.
Topoisomerase I requirement for death receptor-induced apoptotic nuclear fission
J. Biol. Chem.
283
23200-23208
2008
Homo sapiens
Oksuzoglu, E.; Tekiner-Gulbas, B.; Alper, S.; Temiz-Arpaci, O.; Ertan, T.; Yildiz, I.; Diril, N.; Sener-Aki, E.; Yalcin, I.
Some benzoxazoles and benzimidazoles as DNA topoisomerase I and II inhibitors
J. Enzyme Inhib. Med. Chem.
23
37-42
2008
Bos taurus (P68698)
Gul, H.I.; Cizmecioglu, M.; Zencir, S.; Gul, M.; Canturk, P.; Atalay, M.; Topcu, Z.
Cytotoxic activity of 4-hydroxychalcone derivatives against Jurkat cells and their effects on mammalian DNA topoisomerase I
J. Enzyme Inhib. Med. Chem.
24
804-807
2009
Homo sapiens
Alpan, A.S.; Zencir, S.; Zupko, I.; Coban, G.; Rethy, B.; Gunes, H.S.; Topcu, Z.
Biological activity of bis-benzimidazole derivatives on DNA topoisomerase I and HeLa, MCF7 and A431 cells
J. Enzyme Inhib. Med. Chem.
24
844-849
2009
Homo sapiens
Diana, P.; Martorana, A.; Barraja, P.; Montalbano, A.; Dattolo, G.; Cirrincione, G.; Dallacqua, F.; Salvador, A.; Vedaldi, D.; Basso, G.; Viola, G.
Isoindolo[2,1-a]quinoxaline derivatives, novel potent antitumor agents with dual inhibition of tubulin polymerization and topoisomerase I
J. Med. Chem.
51
2387-2399
2008
Homo sapiens
Cinelli, M.A.; Morrell, A.; Dexheimer, T.S.; Scher, E.S.; Pommier, Y.; Cushman, M.
Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors
J. Med. Chem.
51
4609-4619
2008
Homo sapiens (P11387)
Lotito, L.; Russo, A.; Chillemi, G.; Bueno, S.; Cavalieri, D.; Capranico, G.
Global transcription regulation by DNA topoisomerase I in exponentially growing Saccharomyces cerevisiae cells: activation of telomere-proximal genes by TOP1 deletion
J. Mol. Biol.
377
311-322
2008
Saccharomyces cerevisiae
Cheng, B.; Annamalai, T.; Sorokin, E.; Abrenica, M.; Aedo, S.; Tse-Dinh, Y.C.
Asp-to-Asn substitution at the first position of the DxD TOPRIM motif of recombinant bacterial topoisomerase I is extremely lethal to E. coli
J. Mol. Biol.
385
558-567
2009
Escherichia coli, Yersinia pestis (Q7CIL8), Yersinia pestis
Zehorai, E.; Eitan, E.; Hershfinkel, M.; Sekler, I.; Priel, E.
Glutamate regulates the activity of topoisomerase I in mouse cerebellum
Mol. Neurobiol.
38
242-252
2008
Mus musculus
Sorokin, E.P.; Cheng, B.; Rathi, S.; Aedo, S.J.; Abrenica, M.V.; Tse-Dinh, Y.C.
Inhibition of Mg2+ binding and DNA religation by bacterial topoisomerase I via introduction of an additional positive charge into the active site region
Nucleic Acids Res.
36
4788-4796
2008
Yersinia pestis, Escherichia coli (P06612), Escherichia coli
Losasso, C.; Cretaio, E.; Fiorani, P.; DAnnessa, I.; Chillemi, G.; Benedetti, P.
A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance
Nucleic Acids Res.
36
5635-5644
2008
Homo sapiens
Chillemi, G.; DAnnessa, I.; Fiorani, P.; Losasso, C.; Benedetti, P.; Desideri, A.
Thr729 in human topoisomerase I modulates anti-cancer drug resistance by altering protein domain communications as suggested by molecular dynamics simulations
Nucleic Acids Res.
36
5645-5651
2008
Homo sapiens (P11387), Homo sapiens
Sirikantaramas, S.; Yamazaki, M.; Saito, K.
Mutations in topoisomerase I as a self-resistance mechanism coevolved with the production of the anticancer alkaloid camptothecin in plants
Proc. Natl. Acad. Sci. USA
105
6782-6786
2008
Arabidopsis thaliana (P30181), Camptotheca acuminata, Catharanthus roseus, Homo sapiens (P11387), Homo sapiens, Ophiorrhiza japonica, Ophiorrhiza liukiuensis, Ophiorrhiza pumila
Topcu, Z.; Ozturk, B.; Kucukoglu, O.; Kilinc, E.
Flavonoids in Helichrysum pamphylicum inhibit mammalian type I DNA topoisomerase
Z. Naturforsch. C
63
69-74
2008
Mammalia
Pham, M.H.; Kondapalli, N.; Reckord, C.L.; Foglesong, P.D.
Interleukin-2 induces the activities of DNA topoisomerase I and DNA topoisomerase II in HuT 78 cells
Biochem. Biophys. Res. Commun.
390
577-580
2009
Homo sapiens
Lebedeva, N.A.; Rechkunova, N.I.; Agama, K.; Pommier, Y.; Lavrik, O.I.
Interaction of DNA topoisomerase 1 with DNA intermediates and proteins of base excision repair
Biochemistry (Moscow)
74
1278-1284
2009
Homo sapiens
Lee, S.H.; Van, H.T.; Yang, S.H.; Lee, K.T.; Kwon, Y.; Cho, W.J.
Molecular design, synthesis and docking study of benz[b]oxepines and 12-oxobenzo[c]phenanthridinones as topoisomerase 1 inhibitors
Bioorg. Med. Chem. Lett.
19
2444-2447
2009
Homo sapiens (P11387)
Galvez-Peralta, M.; Hackbarth, J.S.; Flatten, K.S.; Kaufmann, S.H.; Hiasa, H.; Xing, C.; Ferguson, D.M.
On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents
Bioorg. Med. Chem. Lett.
19
4459-4462
2009
Homo sapiens
Chua, S.; Quek, N.; Li, M.; Ng, M.; Yuan, W.; Chua, M.; Guo, J.; Koh, L.; Ye, R.; Li, T.
Nick-containing oligonucleotides as human topoisomerase I inhibitors
Bioorg. Med. Chem. Lett.
19
618-623
2009
Homo sapiens
Cho, H.J.; Jung, M.J.; Kwon, Y.; Na, Y.
Oxiranylmethyloxy or thiiranylmethyloxy-azaxanthones and -acridone analogues as potential topoisomerase I inhibitors
Bioorg. Med. Chem. Lett.
19
6766-6769
2009
Homo sapiens
Wang, P.; Ownby, S.; Zhang, Z.; Yuan, W.; Li, S.
Cytotoxicity and inhibition of DNA topoisomerase I of polyhydroxylated triterpenoids and triterpenoid glycosides
Bioorg. Med. Chem. Lett.
20
2790-2796
2010
Homo sapiens
Cinelli, M.A.; Cordero, B.; Dexheimer, T.S.; Pommier, Y.; Cushman, M.
Synthesis and biological evaluation of 14-(aminoalkyl-aminomethyl)aromathecins as topoisomerase I inhibitors: investigating the hypothesis of shared structure-activity relationships
Bioorg. Med. Chem.
17
7145-7155
2009
Homo sapiens (P11387)
Thapa, P.; Karki, R.; Thapa, U.; Jahng, Y.; Jung, M.J.; Nam, J.M.; Na, Y.; Kwon, Y.; Lee, E.S.
2-Thienyl-4-furyl-6-aryl pyridine derivatives: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study
Bioorg. Med. Chem.
18
377-386
2010
Homo sapiens
Barth, S.W.; Briviba, K.; Watzl, B.; Jaeger, N.; Marko, D.; Esselen, M.
In vivo bioassay to detect irinotecan-stabilized DNA/topoisomerase I complexes in rats
Biotechnol. J.
5
321-327
2010
Rattus norvegicus
Annamalai, T.; Dani, N.; Cheng, B.; Tse-Dinh, Y.C.
Analysis of DNA relaxation and cleavage activities of recombinant Mycobacterium tuberculosis DNA topoisomerase I from a new expression and purification protocol
BMC Biochem.
10
18
2009
Escherichia coli, Mycobacterium tuberculosis
Kostopoulos, I.; Karavasilis, V.; Karina, M.; Bobos, M.; Xiros, N.; Pentheroudakis, G.; Kafiri, G.; Papakostas, P.; Vrettou, E.; Fountzilas, G.
Topoisomerase I but not thymidylate synthase is associated with improved outcome in patients with resected colorectal cancer treated with irinotecan containing adjuvant chemotherapy
BMC Cancer
9
339-348
2009
Homo sapiens
Shuai, L.; Wang, S.; Zhang, L.; Fu, B.; Zhou, X.
Cationic porphyrins and analogues as new DNA topoisomerase I and II inhibitors
Chem. Biodivers.
6
827-837
2009
Homo sapiens
Eisenreich, A.; Bogdanov, V.Y.; Zakrzewicz, A.; Pries, A.; Antoniak, S.; Poller, W.; Schultheiss, H.P.; Rauch, U.
Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells
Circ. Res.
104
589-599
2009
Homo sapiens
You, Q.D.; Li, Z.Y.; Huang, C.H.; Yang, Q.; Wang, X.J.; Guo, Q.L.; Chen, X.G.; He, X.G.; Li, T.K.; Chern, J.W.
Discovery of a novel series of quinolone and naphthyridine derivatives as potential topoisomerase I inhibitors by scaffold modification
J. Med. Chem.
52
5649-5661
2009
Homo sapiens
Song, Y.; Shao, Z.; Dexheimer, T.S.; Scher, E.S.; Pommier, Y.; Cushman, M.
Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors
J. Med. Chem.
53
1979-1989
2010
Homo sapiens (P11387), Homo sapiens
Ganguly, A.; Sengupta, S.; Bosedasgupta, S.; Roy, A.; Majumder, H.K.
Mutational studies reveal lysine 352 on the large subunit is indispensable for catalytic activity of bi-subunit topoisomerase I from Leishmania donovani
Mol. Biochem. Parasitol.
165
57-66
2009
Leishmania donovani
Chan, A.; Chang, W.; Chen, L.; Lee, C.; Chen, C.; Lin, C.; Hwang, J.
Evodiamine stabilizes topoisomerase I-DNA cleavable complex to inhibit topoisomerase I activity
Molecules
14
1342-1352
2009
Homo sapiens
Tuduri, S.; Crabbe, L.; Conti, C.; Tourriere, H.; Holtgreve-Grez, H.; Jauch, A.; Pantesco, V.; De Vos, J.; Thomas, A.; Theillet, C.; Pommier, Y.; Tazi, J.; Coquelle, A.; Pasero, P.
Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription
Nat. Cell Biol.
11
1315-1324
2009
Homo sapiens
Malina, J.; Vrana, O.; Brabec, V.
Mechanistic studies of the modulation of cleavage activity of topoisomerase I by DNA adducts of mono- and bi-functional PtII complexes
Nucleic Acids Res.
37
5432-5442
2009
Homo sapiens
Fiorani, P.; Tesauro, C.; Mancini, G.; Chillemi, G.; D'Annessa, I.; Graziani, G.; Tentori, L.; Muzi, A.; Desideri, A.
Evidence of the crucial role of the linker domain on the catalytic activity of human topoisomerase I by experimental and simulative characterization of the Lys681Ala mutant
Nucleic Acids Res.
37
6849-6858
2009
Homo sapiens
Wang, Y.; Deng, D.; Bian, Y.; Xie, Q.; Lv, Y.
Cloning and characterization of DNA topoisomerase I gene Top1 from maize (Zea mays L.)
Plant Sci.
178
47-54
2010
Zea mays (C6KE75)
Szklarczyk, O.; Staron, K.; Cieplak, M.
Native state dynamics and mechanical properties of human topoisomerase I within a structure-based coarse-grained model
Proteins
77
420-431
2009
Homo sapiens (P11387), Homo sapiens
Park, J.E.; Kim, H.I.; Park, J.W.; Park, J.K.; Lee, J.S.
Cloning and biochemical characterization of Staphylococcus aureus type IA DNA topoisomerase comprised of distinct five domains
Arch. Biochem. Biophys.
508
78-86
2011
Staphylococcus aureus (Q06AK7), Staphylococcus aureus, Staphylococcus aureus C-66 (Q06AK7)
Yang, Q.; Liu, Y.; Huang, F.; He, Z.G.
Physical and functional interaction between D-ribokinase and topoisomerase I has opposite effects on their respective activity in Mycobacterium smegmatis and Mycobacterium tuberculosis
Arch. Biochem. Biophys.
512
135-142
2011
Mycobacterium tuberculosis (P9WG49), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Rv (P9WG49), Mycolicibacterium smegmatis
Stahley, M.R.; Stivers, J.T.
Mechanism and specificity of DNA strand exchange catalyzed by vaccinia DNA topoisomerase type I
Biochemistry
49
2786-2795
2010
Vaccinia virus
Capranico, G.; Marinello, J.; Baranello, L.
Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: implications for physiological and therapeutic modulation of enzyme activity
Biochim. Biophys. Acta
1806
240-250
2010
Homo sapiens
Karki, R.; Thapa, P.; Kang, M.J.; Jeong, T.C.; Nam, J.M.; Kim, H.L.; Na, Y.; Cho, W.J.; Kwon, Y.; Lee, E.S.
Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines
Bioorg. Med. Chem.
18
3066-3077
2010
Homo sapiens
Khadka, D.B.; Le, Q.M.; Yang, S.H.; Van, H.T.; Le, T.N.; Cho, S.H.; Kwon, Y.; Lee, K.T.; Lee, E.S.; Cho, W.J.
Design, synthesis and docking study of 5-amino substituted indeno[1,2-c]isoquinolines as novel topoisomerase I inhibitors
Bioorg. Med. Chem.
19
1924-1929
2011
Homo sapiens
Shi, W.; Marcus, S.L.; Lowary, T.L.
Cytotoxicity and topoisomerase I/II inhibition of glycosylated 2-phenyl-indoles, 2-phenyl-benzo[b]thiophenes and 2-phenyl-benzo[b]furans
Bioorg. Med. Chem.
19
603-612
2011
Homo sapiens
Narula, G.; Becker, J.; Cheng, B.; Dani, N.; Abrenica, M.V.; Tse-Dinh, Y.C.
The DNA relaxation activity and covalent complex accumulation of Mycobacterium tuberculosis topoisomerase I can be assayed in Escherichia coli: application for identification of potential FRET-dye labeling sites
BMC Biochem.
11
41
2010
Mycobacterium tuberculosis
Jeong, B.; Choi, H.; Thapa, P.; Karki, R.; Lee, E.; Nam, J.; Na, Y.; Ha, E.; Kwon, Y.; Lee, E.
Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of rigid analogues of 2,4,6-trisubstituted pyridine containing 5,6-dihydrobenzo[h]quinoline moiety
Bull. Korean Chem. Soc.
32
303-306
2011
Homo sapiens
-
Kurtzberg, L.S.; Roth, S.; Krumbholz, R.; Crawford, J.; Bormann, C.; Dunham, S.; Yao, M.; Rouleau, C.; Bagley, R.G.; Yu, X.J.; Wang, F.; Schmid, S.M.; Lavoie, E.J.; Teicher, B.A.
Genz-644282, a novel non-camptothecin topoisomerase I inhibitor for cancer treatment
Clin. Cancer Res.
17
2777-2787
2011
Homo sapiens, Mus musculus, Mus musculus BALB/c
Arlt, M.F.; Glover, T.W.
Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites
DNA Repair
9
678-689
2010
Homo sapiens
Banerjee, B.; Sen, N.; Majumder, H.K.
Identification of a functional type IA topoisomerase, LdTopIIIbeta, from kinetoplastid parasite Leishmania donovani
Enzyme Res.
2011
230542
2011
Leishmania donovani (D0EG00), Leishmania donovani, Leishmania donovani AG 83 (D0EG00)
Jun, K.Y.; Lee, E.Y.; Jung, M.J.; Lee, O.H.; Lee, E.S.; Park Choo, H.Y.; Na, Y.; Kwon, Y.
Synthesis, biological evaluation, and molecular docking study of 3-(3-heteroatom substituted-2-hydroxy-1-propyloxy) xanthone analogues as novel topoisomerase IIalpha catalytic inhibitor
Eur. J. Med. Chem.
46
1964-1971
2011
Homo sapiens
Thapa, U.; Thapa, P.; Karki, R.; Yun, M.; Choi, J.H.; Jahng, Y.; Lee, E.; Jeon, K.H.; Na, Y.; Ha, E.M.; Cho, W.J.; Kwon, Y.; Lee, E.S.
Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship
Eur. J. Med. Chem.
46
3201-3209
2011
Homo sapiens
Narula, G.; Annamalai, T.; Aedo, S.; Cheng, B.; Sorokin, E.; Wong, A.; Tse-Dinh, Y.C.
The strictly conserved Arg-321 residue in the active site of Escherichia coli topoisomerase I plays a critical role in DNA rejoining
J. Biol. Chem.
286
18673-18680
2011
Escherichia coli, Yersinia pestis
Peterson, K.E.; Cinelli, M.A.; Morrell, A.E.; Mehta, A.; Dexheimer, T.S.; Agama, K.; Antony, S.; Pommier, Y.; Cushman, M.
Alcohol-, diol-, and carbohydrate-substituted indenoisoquinolines as topoisomerase I inhibitors: investigating the relationships involving stereochemistry, hydrogen bonding, and biological activity
J. Med. Chem.
54
4937-4953
2011
Homo sapiens
Arjmand, F.; Muddassir, M.
Design and synthesis of heterobimetallic topoisomerase I and II inhibitor complexes: In vitro DNA binding, interaction with 5'-GMP and 5'-TMP and cleavage studies
J. Photochem. Photobiol. B
101
37-46
2010
Homo sapiens
Huang, F.; He, Z.G.
Characterization of an interplay between a Mycobacterium tuberculosis MazF homolog, Rv1495 and its sole DNA topoisomerase I
Nucleic Acids Res.
38
8219-8230
2010
Mycobacterium tuberculosis, Mycolicibacterium smegmatis
Gentry, A.C.; Juul, S.; Veigaard, C.; Knudsen, B.R.; Osheroff, N.
The geometry of DNA supercoils modulates the DNA cleavage activity of human topoisomerase I
Nucleic Acids Res.
39
1014-1022
2011
Homo sapiens
Zhang, Z.; Cheng, B.; Tse-Dinh, Y.C.
Crystal structure of a covalent intermediate in DNA cleavage and rejoining by Escherichia coli DNA topoisomerase I
Proc. Natl. Acad. Sci. USA
108
6939-6944
2011
Escherichia coli
Xu, X.; Leng, F.
A rapid procedure to purify Escherichia coli DNA topoisomerase I
Protein Expr. Purif.
77
214-219
2011
Escherichia coli
Patel, A.; Yakovleva, L.; Shuman, S.; Mondragon, A.
Crystal structure of a bacterial topoisomerase IB in complex with DNA reveals a secondary DNA binding site
Structure
18
725-733
2010
Deinococcus radiodurans
Godbole, A.A.; Leelaram, M.N.; Bhat, A.G.; Jain, P.; Nagaraja, V.
Characterization of DNA topoisomerase I from Mycobacterium tuberculosis: DNA cleavage and religation properties and inhibition of its activity
Arch. Biochem. Biophys.
528
197-203
2012
Mycobacterium tuberculosis (A5U8X0), Mycobacterium tuberculosis, Mycobacterium tuberculosis H37Ra / ATCC 25177 (A5U8X0)
Terekhova, K.; Marko, J.F.; Mondragon, A.
Studies of bacterial topoisomerases I and III at the single-molecule level
Biochem. Soc. Trans.
41
571-575
2013
Escherichia coli
Ishikawa, T.; Krzysko, K.A.; Kowalska-Loth, B.; Skrajna, A.M.; Czubaty, A.; Girstun, A.; Cieplak, M.K.; Lesyng, B.; Staron, K.
Activities of topoisomerase I in its complex with SRSF1
Biochemistry
51
1803-1816
2012
Homo sapiens
Lu, J.; Wang, W.; Tan, G.; Landry, A.P.; Yi, P.; Si, F.; Ren, Y.; Ding, H.
Escherichia coli topoisomerase I is an iron and zinc binding protein
Biometals
24
729-736
2011
Escherichia coli
Cheng, Z.; Tan, G.; Wang, W.; Su, X.; Landry, A.P.; Lu, J.; Ding, H.
Iron and zinc binding activity of Escherichia coli topoisomerase I homolog YrdD
Biometals
27
229-236
2014
Escherichia coli
Ashour, A.; El-Sharkawy, S.; Amer, M.; Abdel Bar, F.; Katakura, Y.; Miyamoto, T.; Toyota, N.; Bang, T.H.; Kondo, R.; Shimizu, K.
Rational design and synthesis of topoisomerase I and II inhibitors based on oleanolic acid moiety for new anti-cancer drugs
Bioorg. Med. Chem.
22
211-220
2014
Homo sapiens
Arno, B.; Coletta, A.; Tesauro, C.; Zuccaro, L.; Fiorani, P.; Lentini, S.; Galloni, P.; Conte, V.; Floris, B.; Desideri, A.
A small organic compound enhances the religation reaction of human topoisomerase I and identifies crucial elements for the religation mechanism
Biosci. Rep.
33
e00025
2013
Homo sapiens
Senarisoy, M.; Canturk, P.; Zencir, S.; Baran, Y.; Topcu, Z.
Gossypol interferes with both type I and type II topoisomerase activities without generating strand breaks
Cell Biochem. Biophys.
66
199-204
2013
Bos taurus
Liu, W.; Zhu, L.; Guo, W.; Zhuang, C.; Zhang, Y.; Sheng, C.; Cheng, P.; Yao, J.; Wang, W.; Dong, G.; Wang, S.; Miao, Z.; Zhang, W.
Synthesis and biological evaluation of novel 7-acyl homocamptothecins as Topoisomerase I inhibitors
Eur. J. Med. Chem.
46
2408-2414
2011
Homo sapiens
Liu, I.F.; Sutherland, J.H.; Cheng, B.; Tse-Dinh, Y.C.
Topoisomerase I function during Escherichia coli response to antibiotics and stress enhances cell killing from stabilization of its cleavage complex
J. Antimicrob. Chemother.
66
1518-1524
2011
Escherichia coli, Escherichia coli RFM475
Szafran, M.; Skut, P.; Ditkowski, B.; Ginda, K.; Chandra, G.; Zakrzewska-Czerwinska, J.; Jakimowicz, D.
Topoisomerase I (TopA) is recruited to ParB complexes and is required for proper chromosome organization during Streptomyces coelicolor sporulation
J. Bacteriol.
195
4445-4455
2013
Streptomyces coelicolor
Slesarev, A.I.; Zaitzev, D.A.; Kopylov, V.M.; Stetter, K.O.; Kozyavkin, S.A.
DNA topoisomerase III from extremely thermophilic archaebacteria. ATP-independent type I topoisomerase from Desulfurococcus amylolyticus drives extensive unwinding of closed circular DNA at high temperature
J. Biol. Chem.
266
12321-12328
1991
Desulfurococcus amylolyticus, Desulfurococcus amylolyticus DSM 3822
Valenti, A.; Perugino, G.; Varriale, A.; D'Auria, S.; Rossi, M.; Ciaramella, M.
The archaeal topoisomerase reverse gyrase is a helix-destabilizing protein that unwinds four-way DNA junctions
J. Biol. Chem.
285
36532-36541
2010
Saccharolobus solfataricus, Saccharolobus solfataricus P2
Valenti, A.; de Felice, M.; Perugino, G.; Bizard, A.; Nadal, M.; Rossi, M.; Ciaramella, M.
Synergic and opposing activities of thermophilic RecQ-like helicase and topoisomerase 3 proteins in Holliday junction processing and replication fork stabilization
J. Biol. Chem.
287
30282-30295
2012
Saccharolobus solfataricus
Li, X.; Guo, L.; Deng, L.; Feng, D.; Ren, Y.; Chu, Y.; She, Q.; Huang, L.
Deletion of the topoisomerase III gene in the hyperthermophilic archaeon Sulfolobus islandicus results in slow growth and defects in cell cycle control
J. Genet. Genomics
38
253-259
2011
Sulfolobus islandicus (F0NEW3), Sulfolobus islandicus, Sulfolobus islandicus Rey15A (F0NEW3)
Conda-Sheridan, M.; Reddy, P.V.; Morrell, A.; Cobb, B.T.; Marchand, C.; Agama, K.; Chergui, A.; Renaud, A.; Stephen, A.G.; Bindu, L.K.; Pommier, Y.; Cushman, M.
Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1)
J. Med. Chem.
56
182-200
2013
Homo sapiens
Hansen, G.; Harrenga, A.; Wieland, B.; Schomburg, D.; Reinemer, P.
Crystal structure of full length topoisomerase I from Thermotoga maritima
J. Mol. Biol.
358
1328-1340
2006
Thermotoga maritima (P46799), Thermotoga maritima, Thermotoga maritima MSB8 / DSM 3109 / ATCC 43589 (P46799)
Bizard, A.; Garnier, F.; Nadal, M.
TopR2, the second reverse gyrase of Sulfolobus solfataricus, exhibits unusual properties.
J. Mol. Biol.
408
839-849
2011
Saccharolobus solfataricus
Gongora, C.; Vezzio-Vie, N.; Tuduri, S.; Denis, V.; Causse, A.; Auzanneau, C.; Collod-Beroud, G.; Coquelle, A.; Pasero, P.; Pourquier, P.; Martineau, P.; Del Rio, M.
New topoisomerase I mutations are associated with resistance to camptothecin
Mol. Cancer
10
64
2011
Homo sapiens
Terekhova, K.; Gunn, K.H.; Marko, J.F.; Mondragon, A.
Bacterial topoisomerase I and topoisomerase III relax supercoiled DNA via distinct pathways
Nucleic Acids Res.
40
10432-10440
2012
Escherichia coli
Narula, G.; Tse-Dinh, Y.C.
Residues of E. coli topoisomerase I conserved for interaction with a specific cytosine base to facilitate DNA cleavage
Nucleic Acids Res.
40
9233-9243
2012
Escherichia coli
Ahmed, W.; Bhat, A.G.; Leelaram, M.N.; Menon, S.; Nagaraja, V.
Carboxyl terminal domain basic amino acids of mycobacterial topoisomerase I bind DNA to promote strand passage
Nucleic Acids Res.
41
7462-7471
2013
Mycolicibacterium smegmatis
Laco, G.S.
Evaluation of two models for human topoisomerase I interaction with dsDNA and camptothecin derivatives
PLoS ONE
6
e24314
2011
Homo sapiens
Drwal, M.N.; Agama, K.; Wakelin, L.P.; Pommier, Y.; Griffith, R.
Exploring DNA topoisomerase I ligand space in search of novel anticancer agents
PLoS ONE
6
e25150
2011
Homo sapiens
Douarre, C.; Sourbier, C.; Dalla Rosa, I.; Brata Das, B.; Redon, C.E.; Zhang, H.; Neckers, L.; Pommier, Y.
Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism
PLoS ONE
7
e41094
2012
Homo sapiens
Cortopassi, W.A.; Penna-Coutinho, J.; Aguiar, A.C.; Pimentel, A.S.; Buarque, C.D.; Costa, P.R.; Alves, B.R.; Franca, T.C.; Krettli, A.U.
Theoretical and experimental studies of new modified isoflavonoids as potential inhibitors of topoisomerase I from Plasmodium falciparum
PLoS ONE
9
e91191
2014
Homo sapiens, Plasmodium falciparum
Proszek, J.; Roy, A.; Jakobsen, A.K.; Fr?hlich, R.; Knudsen, B.R.; Stougaard, M.
Topoisomerase I as a biomarker: detection of activity at the single molecule level
Sensors
14
1195-1207
2013
Homo sapiens
Rajan, R.; Osterman, A.K.; Gast, A.T.; Mondragn, A.
Biochemical characterization of the topoisomerase domain of Methanopyrus kandleri topoisomerase V
J. Biol. Chem.
289
28898-28909
2014
Methanopyrus kandleri
Tian, Q.T.; Ding, C.Y.; Song, S.S.; Wang, Y.Q.; Zhang, A.; Miao, Z.H.
New tanshinone I derivatives S222 and S439 similarly inhibit topoisomerase I/II but reveal different p53-dependency in inducing G2/M arrest and apoptosis
Biochem. Pharmacol.
154
255-264
2018
Homo sapiens (P11387)
Kupriyanova, E.V.; Albert, E.V.; Bliznina, A.I.; Mamoshina, P.O.; Ezhova, T.A.
Arabidopsis DNA topoisomerase I alpha is required for adaptive response to light and flower development
Biol. Open
6
832-843
2017
Arabidopsis thaliana
de Oliveira Figueiredo, P.; Perdomo, R.T.; Garcez, F.R.; de Fatima Cepa Matos, M.; de Carvalho, J.E.; Garcez, W.S.
Further constituents of Galianthe thalictroides (Rubiaceae) and inhibition of DNA topoisomerases I and IIalpha by its cytotoxic beta-carboline alkaloids
Bioorg. Med. Chem. Lett.
24
1358-1361
2014
Homo sapiens
Puc, J.; Kozbial, P.; Li, W.; Tan, Y.; Liu, Z.; Suter, T.; Ohgi, K.A.; Zhang, J.; Aggarwal, A.K.; Rosenfeld, M.G.
Ligand-dependent enhancer activation regulated by topoisomerase-I activity
Cell
160
367-380
2015
Homo sapiens
Ang, R.; Teoh, L.; Chan, M.; Miswan, N.; Khoo, B.
Comparing the expression of human DNA topoisomerase I in KM71H and X33 strains of Pichia pastoris
Electron. J. Biotechnol.
21
9-17
2016
Homo sapiens
-
Yu, L.M.; Zhang, X.R.; Li, X.B.; Yang, Y.; Wei, H.Y.; He, X.X.; Gu, L.Q.; Huang, Z.S.; Pommier, Y.; An, L.K.
Synthesis and biological evaluation of 6-substituted indolizinoquinolinediones as catalytic DNA topoisomerase I inhibitors
Eur. J. Med. Chem.
101
525-533
2015
Homo sapiens
Wu, G.; Qi, X.; Mo, X.; Yu, G.; Wang, Q.; Zhu, T.; Gu, Q.; Liu, M.; Li, J.; Li, D.
Structure-based discovery of cytotoxic dimeric tetrahydroxanthones as potential topoisomerase I inhibitors from a marine-derived fungus
Eur. J. Med. Chem.
148
268-278
2018
Homo sapiens
Tiwari, P.B.; Chapagain, P.P.; Banda, S.; Darici, Y.; Ueren, A.; Tse-Dinh, Y.C.
Characterization of molecular interactions between Escherichia coli RNA polymerase and topoisomerase I by molecular simulations
FEBS Lett.
590
2844-2851
2016
Escherichia coli (P06612), Escherichia coli
Kumar, A.; Bora, U.
Molecular docking studies of curcumin natural derivatives with DNA topoisomerase I and II-DNA complexes
Interdiscip. Sci. Comput. Life Sci.
6
285-291
2014
Homo sapiens (P11387)
Viard, T.; Lamour, V.; Duguet, M.; Bouthier de la Tour, C.
Hyperthermophilic topoisomerase I from Thermotoga maritima A very efficient enzyme that functions independently of zinc binding
J. Biol. Chem.
276
46495-46503
2001
Thermotoga maritima (P46799), Thermotoga maritima, Thermotoga maritima DSM 3109 (P46799)
Wright, C.M.; van der Merwe, M.; DeBrot, A.H.; Bjornsti, M.A.
DNA topoisomerase I domain interactions impact enzyme activity and sensitivity to camptothecin
J. Biol. Chem.
290
12068-12078
2015
Homo sapiens
Jensen, N.F.; Agama, K.; Roy, A.; Smith, D.H.; Pfister, T.D.; R?mer, M.U.; Zhang, H.L.; Doroshow, J.H.; Knudsen, B.R.; Stenvang, J.; Bruenner, N.; Pommier, Y.
Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations
J. Exp. Clin. Cancer Res.
35
56
2016
Homo sapiens
Castelli, S.; Gonalves, M.; Katkar, P.; Stuchi, G.; Couto, R.; Petrilli, H.; da Costa Ferreira, A.
Comparative studies of oxindolimine-metal complexes as inhibitors of human DNA topoisomerase IB
J. Inorg. Biochem.
186
85-94
2018
Homo sapiens (P11387), Homo sapiens
Ranjan, N.; Story, S.; Fulcrand, G.; Leng, F.; Ahmad, M.; King, A.; Sur, S.; Wang, W.; Tse-Dinh, Y.C.; Arya, D.P.
Selective inhibition of Escherichia coli RNA and DNA topoisomerase I by Hoechst 33258 derived mono- and bisbenzimidazoles
J. Med. Chem.
60
4904-4922
2017
Escherichia coli, Homo sapiens
Tan, K.; Cao, N.; Cheng, B.; Joachimiak, A.; Tse-Dinh, Y.C.
Insights from the structure of Mycobacterium tuberculosis topoisomerase I with a novel protein fold
J. Mol. Biol.
428
182-193
2016
Mycobacterium tuberculosis
D'Alfonso, A.; Di Felice, F.; Carlini, V.; Wright, C.M.; Hertz, M.I.; Bjornsti, M.A.; Camilloni, G.
Molecular mechanism of DNA topoisomerase I-dependent rDNA silencing Sir2p recruitment at ribosomal genes
J. Mol. Biol.
428
4905-4916
2016
Saccharomyces cerevisiae, Homo sapiens (P11387), Homo sapiens, Saccharomyces cerevisiae W303-1A
Xin, L.T.; Liu, L.; Shao, C.L.; Yu, R.L.; Chen, F.L.; Yue, S.J.; Wang, M.; Guo, Z.L.; Fan, Y.C.; Guan, H.S.; Wang, C.Y.
Discovery of DNA topoisomerase I inhibitors with low-cytotoxicity based on virtual screening from natural products
Mar. Drugs
15
pii: E217
2017
Homo sapiens (P11387), Homo sapiens
Sirikantaramas, S.; Meeprasert, A.; Rungrotmongkol, T.; Fuji, H.; Hoshino, T.; Sudo, H.; Yamazaki, M.; Saito, K.
Structural insight of DNA topoisomerases I from camptothecin-producing plants revealed by molecular dynamics simulations
Phytochemistry
113
50-56
2015
Ophiorrhiza pumila, Nothapodytes nimmoniana (A0A097ZNA3), Nothapodytes nimmoniana, Camptotheca acuminata (B2DDA7), Camptotheca acuminata
Liu, X.; Gao, L.; Dinh, T.T.; Shi, T.; Li, D.; Wang, R.; Guo, L.; Xiao, L.; Chen, X.
DNA topoisomerase I affects polycomb group protein-mediated epigenetic regulation and plant development by altering nucleosome distribution in Arabidopsis
Plant Cell
26
2803-2817
2014
Arabidopsis thaliana (P30181), Arabidopsis thaliana
Chan, M.K.; Lim, S.K.; Miswan, N.; Chew, A.L.; Noordin, R.; Khoo, B.Y.
Expression of stable and active human DNA topoisomerase I in Pichia pastoris
Protein Expr. Purif.
141
52-62
2018
Homo sapiens
Gokduman, K.
Strategies targeting DNA topoisomerase I in cancer chemotherapy camptothecins, nanocarriers for camptothecins, organic non-camptothecin compounds and metal complexes
Curr. Drug Targets
17
1928-1939
2016
Homo sapiens
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