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Literature summary for 5.6.2.1 extracted from
- Clinical pharmacokinetics of irinotecan (1997), Clin. Pharmacokinet., 33, 245-259.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 7-Ethyl-10-hydroxy-camptothecin | review of clinical pharmacokinetics | Mammalia |  |
| 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxy-camptothecin | i.e. irinotecan; review of clinical pharmacokinetics | Mammalia | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mammalia | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| supercoiled DNA | relaxation | Mammalia | relaxed closed circular DNA | - |
? | |
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