Literature summary for 5.6.2.1 extracted from

Song, Y.; Shao, Z.; Dexheimer, T.S.; Scher, E.S.; Pommier, Y.; Cushman, M.
Structure-based design, synthesis, and biological studies of new anticancer norindenoisoquinoline topoisomerase I inhibitors (2010), J. Med. Chem., 53, 1979-1989.

Search for more literature for 5.6.2.1

Inhibitors

Inhibitors	Comment	Organism	Structure
2,3-dimethoxy-8,9-methylenedioxy-10-(1H-imidazol-yl)methyl-11H-indeno[1,2-c]isoquinoline	-	Homo sapiens
2,3-dimethoxy-8,9-methylenedioxy-10-(4-methylpiperazin-1-yl)-methyl-11H-indeno[1,2-c]isoquinoline	-	Homo sapiens
2,3-dimethoxy-8,9-methylenedioxy-10-(4-morpholino)methyl-11H-indeno[1,2-c]isoquinoline	-	Homo sapiens
2,3-dimethoxy-8,9-methylenedioxy-10-(dimethylamino)methyl-11H-indeno[1,2-c]isoquinoline	influence of protonation state on Top1 inhibition	Homo sapiens
2,3-dimethoxy-8,9-methylenedioxy-10-(N,N',N'-trimethylethylenediamino)methyl-11H-indeno[1,2-c]isoquinoline	-	Homo sapiens
2,3-dimethoxy-8,9-methylenedioxy-10-(pyrrolidin-1-yl)methyl-11H-indeno[1,2-c]isoquinoline	influence of protonation state on Top1 inhibition	Homo sapiens
2,3-dimethoxy-8,9-methylenedioxy-10-methyl-11H-indeno[1,2-c]-isoquinoline	-	Homo sapiens
indenoisoquinoline	NSC314622	Homo sapiens
additional information	cytotoxicities in cancer cells and topoisomerase I inhibitory activities of norindenoisoquinoline derivatives, molecular modeling, overview; inhibitor binding in the topoisomerase I-DNA covalent complex, molecular docking and quantum chemical calculations, overview	Homo sapiens
norindenoisoquinoline	-	Homo sapiens
topotecan	-	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Homo sapiens	5634	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P11387	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
carcinoma cell	-	Homo sapiens	-
DU-145 cell	a prostate cancer cell line	Homo sapiens	-
HCT-116 cell	-	Homo sapiens	-
HOP-62 cell	a lung cancer cell line	Homo sapiens	-
MDA-MB-435 cell	a breast cancer cell line	Homo sapiens	-
OVCAR-3 cell	-	Homo sapiens	-
SF-539 cell	a CNS tumor cell line	Homo sapiens	-
SN-12C cell	a renal cancer cell line	Homo sapiens	-
UACC-62 cell	a melanoma cell line	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Topoisomerase I	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)