Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,5-dideoxy-1-(5,11-dioxo-5,11-dihydro-6H-indeno[1,2-c]isoquinolin-6-yl)-D-xylo-hexitol | - |
Homo sapiens | |
1-deoxy-1-(3-nitro-5,11-dioxo-5,11-dihydro-6H-indeno[1,2-c]isoquinolin-6-yl)-D-glucitol | - |
Homo sapiens | |
1-deoxy-1-(5,11-dioxo-5,11-dihydro-6H-indeno[1,2-c]isoquinolin-6-yl)-D-allitol | - |
Homo sapiens | |
1-deoxy-1-(5,11-dioxo-5,11-dihydro-6H-indeno[1,2-c]isoquinolin-6-yl)-D-arabinitol | - |
Homo sapiens | |
1-deoxy-1-(5,11-dioxo-5,11-dihydro-6H-indeno[1,2-c]isoquinolin-6-yl)-D-galactitol | - |
Homo sapiens | |
1-deoxy-1-(5,11-dioxo-5,11-dihydro-6H-indeno[1,2-c]isoquinolin-6-yl)-D-glucitol | - |
Homo sapiens | |
1-deoxy-1-(5,11-dioxo-5,11-dihydro-6H-indeno[1,2-c]isoquinolin-6-yl)-D-mannitol | - |
Homo sapiens | |
1-deoxy-1-(5,11-dioxo-5,11-dihydro-6H-indeno[1,2-c]isoquinolin-6-yl)-D-ribitol | - |
Homo sapiens | |
2,3-dimethoxy-6-methyl-5H-[1,3]dioxolo[5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione | - |
Homo sapiens | |
5-deoxy-5-(5,11-dioxo-5,11-dihydro-6H-indeno[1,2-c]isoquinolin-6-yl)-D-arabinitol | - |
Homo sapiens | |
6-(1-hydroxypropan-2-yl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione | - |
Homo sapiens | |
6-(2,3-dihydroxypropyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione | - |
Homo sapiens | |
6-(2-hydroxypropyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione | - |
Homo sapiens | |
6-(3-amino-2-hydroxypropyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione | - |
Homo sapiens | |
6-(3-hydroxy-2-oxopropyl)-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione | - |
Homo sapiens | |
6-[(2R)-1-hydroxypropan-2-yl]-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione | - |
Homo sapiens | |
6-[(2R)-2,3-dihydroxypropyl]-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione | - |
Homo sapiens | |
6-[(2R)-2-hydroxypropyl]-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione | - |
Homo sapiens | |
6-[(2S)-1-hydroxypropan-2-yl]-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione | - |
Homo sapiens | |
6-[(2S)-2,3-dihydroxypropyl]-2,3-dimethoxy-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione | - |
Homo sapiens | |
6-[(2S)-2,3-dihydroxypropyl]-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione | - |
Homo sapiens | |
6-[(2S)-2-hydroxypropyl]-5H-indeno[1,2-c]isoquinoline-5,11(6H)-dione | - |
Homo sapiens | |
6-[3-(1H-imidazol-1-yl)propyl]-2,3-dimethoxy-5H-[1,3]dioxolo[5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione | - |
Homo sapiens | |
6-[3-[(2-hydroxyethyl)amino]propyl]-2,3-dimethoxy-5H-[1,3]dioxolo[5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione | - |
Homo sapiens | |
camptothecin | - |
Homo sapiens | |
additional information | Top1 can be inhibited by heterocyclic compounds such as indolocarbazoles and indenoisoquinolines. Carbohydrate and hydroxyl-containing side chains are essential for the biological activity of indolocarbazoles. Preparation and inhibitory potency of indenoisoquinolines substituted with short-chain alcohols, diols, and carbohydrates, cytotoxicity, Top1 poisoning activity of diol-substituted indenoisoquinolines is dependent upon stereochemistry, molecular modeling, docking studies, and structure-function relationships, overview. IC50 values for cytotoxic effects in human cancer cell lines, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | required | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | recombinant enzyme | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | usage of a 3'-end radiolabeled DNA substrate, a 117-bp DNA oligonucleotide | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Top1 | - |
Homo sapiens |
Topoisomerase I | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |