Cloned (Comment) | Organism |
---|---|
EKY3 yeast cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A653P | known to be CPT resistant | Homo sapiens |
E418K | the active site tyrosine. The Glu418Lys mutant is active and partially resistant to CPT in yeast cells expressed in yeast cells, display a camptothecin resistance that slowly decreases as a function of time | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
camptothecin | when CPT is added the cleavage religation equilibrium is shifted toward cleavage | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Topoisomerase I | - |
Homo sapiens |