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Literature summary for 5.6.2.1 extracted from

  • Liu, W.; Zhu, L.; Guo, W.; Zhuang, C.; Zhang, Y.; Sheng, C.; Cheng, P.; Yao, J.; Wang, W.; Dong, G.; Wang, S.; Miao, Z.; Zhang, W.
    Synthesis and biological evaluation of novel 7-acyl homocamptothecins as Topoisomerase I inhibitors (2011), Eur. J. Med. Chem., 46, 2408-2414.
    View publication on PubMed
Search for more literature for 5.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
7-(2-furoyl)-10-methoxyhomocamptothecin
-
 Homo sapiens
7-(2-naphthoyl)-10-methoxyhomocamptothecin
-
 Homo sapiens
7-(2-thenoyl)-10-methoxyhomocamptothecin
-
 Homo sapiens
7-(3,5-dimethylbenzoyl)-10-methoxyhomocamptothecin
-
 Homo sapiens
7-(4-chlorbenzoyl)-10-methoxyhomocamptothecin
-
 Homo sapiens
7-(4-fluorobenzoyl)-10-methoxyhomocamptothecin
-
 Homo sapiens
7-(4-methoxylbenzoyl)-10-methoxyhomocamptothecin
-
 Homo sapiens
7-(4-toluyl)-10-methoxyhomocamptothecin
-
 Homo sapiens
7-(4-triflouromethylbenzoyl)-10-methoxyhomocamptothecin
-
 Homo sapiens
7-benzoyl-10-methoxyhomocamptothecin
-
 Homo sapiens
7-butyryl-10-methoxyhomocamptothecin
-
 Homo sapiens
7-cyclohexyl-10-methoxyhomocamptothecin
-
 Homo sapiens
7-cyclohexylcabonyl-10-methoxyhomocamptothecin
-
 Homo sapiens
7-cyclopentyl-10-methoxyhomocamptothecin
-
 Homo sapiens
7-cyclopentylcabonyl-10-methoxyhomocamptothecin
-
 Homo sapiens
7-cyclopropylcabonyl-10-methoxyhomocamptothecin
-
 Homo sapiens
7-heptanoyl-10-methoxyhomocamptothecin
-
 Homo sapiens
7-isobutyryl-10-methoxyhomocamptothecin
-
 Homo sapiens
7-pentanoyl-10-methoxyhomocamptothecin
-
 Homo sapiens
7-propionyl-10-methoxyhomocamptothecin
-
 Homo sapiens
additional information 7-acyl homocamptothecins as topoisomerase I inhibitors, inhibition of induced DNA cleavage and in vitro cytotoxicity against three cancer cell lines A-549, MDA-MB-435 and HCT-116, overview Homo sapiens
topotecan
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
HCT-116 cell
-
 Homo sapiens
-
MDA-MB-435 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Topo I
-
 Homo sapiens
Topoisomerase I
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens