Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P11387 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Topo I catalyses two distinct reactions, the DNA relaxation and the phosphorylation of serine/arginine motifs which are present in essential splicing factors in a mutually exclusive manner, structure-function relationship, molecular dynamics modelling, overview | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | structure-function relationship, molecular dynamics modelling, detailed overview. Topo I is a single polypeptide of 765 amino acid residues comprising four domains called: N-terminal domain with residues M1-G214, core domain with I215-A635, linker domain with P636-K712, and C-terminal domain with Q713-F765 domain. The core domain is further divided into three subdomains that form two distinct lobes in the three-dimensional structure of topo I: the cap region, including subdomains I formed by residues I215-E232 and S320-S433, subdomain II formed by residues P233-M319, and the separate subdomain III consisting of residues R434-A635 | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
Topoisomerase I | - |
Homo sapiens |