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Literature summary for 5.6.2.1 extracted from

  • Dezhenkova, L.G.; Susova, O.Y.; Shchekotikhin, A.E.; Preobrazhenskaya, M.N.; Shtil, A.A.
    Naphtho[2,3-f]indole-5,10-dione aminoalkyl derivatives: a new class of topoisomerase I inhibitors (2008), Bull. Exp. Biol. Med., 145, 334-337.
    View publication on PubMed
Search for more literature for 5.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
2-[4-[(4,11-dihydroxy-5,10-dioxo-5,10-dihydro-1H-naphtho[2,3-f]indol-3-yl)methyl]piperazin-1-yl]ethyl acetate
-
 Homo sapiens
3-[(1-azabicyclo[2.2.2]oct-3-ylamino)methyl]-4,11-dihydroxy-1H-naphtho[2,3-f]indole-5,10-dione
-
 Homo sapiens
3-[(dimethylamino)methyl]-4,11-dihydroxy-1H-naphtho[2,3-f]indole-5,10-dione
-
 Homo sapiens
4,11-bis([2-[(2-hydroxyethyl)amino]ethyl]amino)-1H-naphtho[2,3-f]indole-5,10-dione
-
 Homo sapiens
4,11-bis[(2-aminoethyl)amino]-1H-naphtho[2,3-f]indole-5,10-dione
-
 Homo sapiens
4,11-bis[[2-(dimethylamino)ethyl]amino]-1H-naphtho[2,3-f]indole-5,10-dione
-
 Homo sapiens
4,11-bis{[2-(methylamino)ethyl]amino}-1H-naphtho[2,3-f]indole-5,10-dione
-
 Homo sapiens
4,11-dihydroxy-3-[(4-methylpiperazin-1-yl)methyl]-1H-naphtho[2,3-f]indole-5,10-dione
-
 Homo sapiens
camptothecine
-
 Homo sapiens
doxorubicin
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
Topo I
-
 Homo sapiens
Topoisomerase I
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0015
-
 IC50 values 0.0005 mM to 0.0015 mM for 4,11-bis([2-[(2-hydroxyethyl)amino]ethyl]amino)-1H-naphtho[2,3-f]indole-5,10-dione, 0.0015 mM to 0.0035 mM for 4,11-bis[[2-(methylamino)ethyl]amino]-1H-naphtho[2,3-f]indole-5,10-dione, above 0.0035 mM for 4,11-bis[[2-(dimethylamino)ethyl]amino]-1H-naphtho[2,3-f]indole-5,10-dione Homo sapiens 4,11-bis[(2-aminoethyl)amino]-1H-naphtho[2,3-f]indole-5,10-dione