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Literature summary for 5.6.2.1 extracted from
- Enhanced topoisomerase I activity and increased topoisomerase II alpha content in cisplatin-resistant cancer cell lines (1997), Jpn. J. Cancer Res., 88, 1218-1223.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cisplatin | synergistic action between cisplatin and 7-ethyl-10-hydroxy-camptothecin in Kfr cells, a cisplatin resistant subline of the KF epithelial ovarian carcinoma cell line but not in the parent KF cells | eukaryota |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| eukaryota | - |
- |
- |
| Mammalia | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| ovarian cancer cell line | a cisplatin resistant subline of the KF epithelial ovarian carcinoma cell line | Mammalia | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| supercoiled DNA | relaxation | Mammalia | relaxed closed circular DNA | - |
? | |
| supercoiled DNA | relaxation | eukaryota | relaxed closed circular DNA | - |
? | |
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