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Literature summary for 5.6.2.1 extracted from

  • Kamau, E.; Grove, A.
    Fluoroquinolone-dependent DNA supercoiling by Vaccinia topoisomerase I (2004), J. Mol. Biol., 342, 479-487.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
enrofloxacin inhibits DNA relaxation.When Vaccinia topoisomerase I is present with relaxed DNA in the presence of enrofloxacin, it executes the reverse reaction, supercoiling the DNA Vaccinia virus

Organism

Organism UniProt Comment Textmining
Vaccinia virus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information when Vaccinia topoisomerase I is present with relaxed DNA in the presence of enrofloxacin (inhibitor of relaxation activity), it executes the reverse reaction, supercoiling the DNA Vaccinia virus ?
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