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Literature summary for 5.6.2.1 extracted from

  • Zehorai, E.; Eitan, E.; Hershfinkel, M.; Sekler, I.; Priel, E.
    Glutamate regulates the activity of topoisomerase I in mouse cerebellum (2008), Mol. Neurobiol., 38, 242-252.
    View publication on PubMed
Search for more literature for 5.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
gamma-aminobutyric acid GABA, regulates the activity of topo I in mouse cerebellum sections, slightly and transiently inhibits topo I activity Mus musculus
glutamate regulates the activity of topo I in mouse cerebellum sections. Exhibits a significant time-dependent inhibition of topo I activity but no effect of the enzyme protein level Mus musculus
additional information PARP inhibitors prevent the glutamate, but not GABA, induced decrease in topo I activity Mus musculus
topotecan
-
 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-
nucleus
-
 Mus musculus 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ inhibitory effect of glutamate is mediated by Ca2+ Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cerebellum various regions of mouse brain Mus musculus
-

Synonyms

Synonyms Comment Organism
Topo I
-
 Mus musculus
Topoisomerase I
-
 Mus musculus