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Literature summary for 5.6.2.1 extracted from

  • Spicer, J.A.; Gamage, S.A.; Atwell, G.J.; Finlay, G.J.; Baguley, B.C.; Denny, W.A.
    Structure-activity relationships for acridine-substituted analogues of the mixed topoisomerase I/II inhibitor N-[2-dimethylamino)ethyl]acridine-4-carboxamide (1997), J. Med. Chem., 40, 1919-1929.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide
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Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
JURKAT cell
-
Homo sapiens
-
leukemia cell line
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
supercoiled DNA relaxation Homo sapiens relaxed closed circular DNA
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