Literature summary for 5.6.2.1 extracted from

Bailly, C; Colson, P.; Houssier, C.; Rodrigues-Pereira, E.; Prudhomme, M.; Waring, M.J.
Recognition of specific sequences in DNA by a topoisomerase I inhibitor derived from the antitumor drug rebeccamycin (1998), Mol. Pharmacol., 53, 77-87.

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Inhibitors

Inhibitors	Comment	Organism	Structure
R-3	a synthetic derivative of rebeccamycin that contains a methoxyglucose moiety appended to the indolocarbazole chromophore	eukaryota
R-4	the aglycone of a synthetic derivative of rebeccamycin that contains a methoxyglucose moiety appended to the indolocarbazole chromophore	eukaryota

Organism

Organism	UniProt	Comment	Textmining
eukaryota	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
supercoiled DNA	relaxation	eukaryota	relaxed closed circular DNA	-	?

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Release 2023.1 (January 2023)