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Literature summary for 5.6.2.1 extracted from

  • Belova, G.I.; Prasad, R.; Nazimov, I.V.; Wilson, S.H.; Slesarev, A.I.
    The domain organization and properties of individual domains of DNA topoisomerase V, a type 1B topoisomerase with DNA repair activities (2002), J. Biol. Chem., 277, 4959-4965.
    View publication on PubMed
Search for more literature for 5.6.2.1

Cloned(Commentary)

Cloned (Comment) Organism
three truncated Topo V polypeptides comprising the NH2-terminal 44000 Da and 16000 Da domains, the 44000 Da, 16000 Da and 18000 Da domains and the C-terminal 34000 Da domain Methanopyrus kandleri

Protein Variants

Protein Variants Comment Organism
additional information three truncated Topo V polypeptides comprising the NH2-terminal 44000 Da and 16000 Da domains, the 44000 Da, 16000 Da and 18000 Da domains and the C-terminal 34000 Da domain. Topo61 and Topo78 are active topoisomerases, but in contrast to Topo V these enzymes are inhibited by high salt concentrations. Topo34 has strong DNA-binding ability but shows no topoisomerase activity. Topo78 and Topi34 possess apurinic/apyrimidinic lyase activity that is important in base excision DNA repair Methanopyrus kandleri

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Methanopyrus kandleri the topoisomerase and DNA repair activities reside in different parts of the protein and the DNA repair activity is dispensable for the topoisomerase catalytic activity ?
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 ?

Organism

Organism UniProt Comment Textmining
Methanopyrus kandleri
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Purification (Commentary)

Purification (Comment) Organism
three truncated Topo V polypeptides comprising the NH2-terminal 44000 Da and 16000 Da domains, the 44000 Da, 16000 Da and 18000 Da domains and the C-terminal 34000 Da domain Methanopyrus kandleri

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme has at least two different active centers capable of processing apurinic/apyrimidinic site DNA Methanopyrus kandleri ?
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 ?
additional information the topoisomerase and DNA repair activities reside in different parts of the protein and the DNA repair activity is dispensable for the topoisomerase catalytic activity Methanopyrus kandleri ?
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 ?

Synonyms

Synonyms Comment Organism
topo V
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 Methanopyrus kandleri
topoisomerase V
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 Methanopyrus kandleri