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Literature summary for 5.6.2.1 extracted from

  • Dallavalle, S.; Gattinoni, S.; Mazzini, S.; Scaglioni, L.; Merlini, L.; Tinelli, S.; Beretta, G.L.; Zunino, F.
    Synthesis and cytotoxic activity of a new series of topoisomerase I inhibitors (2008), Bioorg. Med. Chem. Lett., 18, 1484-1489.
    View publication on PubMed
Search for more literature for 5.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
1-hydroxy-8-methoxyanthracene-9,10-dione
-
 Homo sapiens
1-[2-(dimethylamino)ethoxy]-8-methoxyanthracene-9,10-dione
-
 Homo sapiens
11-hydroxy-2-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione
-
 Homo sapiens
11-hydroxy-2-methyl-8-nitro-4H-naphtho[2,3-h]chromene-4,7,12-trione
-
 Homo sapiens
11-hydroxy-2-phenyl-4H-naphtho[2,3-h]chromene-4,7,12-trione
-
 Homo sapiens
11-methoxy-2-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione
-
 Homo sapiens
11-methoxy-2-phenyl-4H-naphtho[2,3-h]chromene-4,7,12-trione
-
 Homo sapiens
11-[2-(dimethylamino)ethoxy]-2-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione
-
 Homo sapiens
3,10-dibromo-11-hydroxy-2-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione
-
 Homo sapiens
3-bromo-11-hydroxy-2-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione
-
 Homo sapiens
4-hydroxy-5-methoxy-1-nitroanthracene-9,10-dione
-
 Homo sapiens
5,9,11-trimethoxy-2-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione
-
 Homo sapiens
topopyrone A
-
 Homo sapiens
topopyrone B
-
 Homo sapiens
topopyrone C
-
 Homo sapiens
topopyrone D
-
 Homo sapiens
topotecan
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
NCI-H460 cell human non-small cell lung cancer cell line Homo sapiens
-

Synonyms

Synonyms Comment Organism
Topo I
-
 Homo sapiens
Topoisomerase I
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
additional information
-
 IC50 value for 11-methoxy-2-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione is more than 0.260 mM, for 1-hydroxy-8-methoxyanthracene-9,10-dione, 5,9,11-trimethoxy-2-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione, 11-methoxy-2-phenyl-4H-naphtho[2,3-h]chromene-4,7,12-trione and 1-[2-(dimethylamino)ethoxy]-8-methoxyanthracene-9,10-dione more than 0.100 mM Homo sapiens additional information
0.00118
-
-
 Homo sapiens topotecan
0.00495
-
-
 Homo sapiens 3,10-dibromo-11-hydroxy-2-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione
0.0055
-
-
 Homo sapiens 11-hydroxy-2-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione
0.0065
-
-
 Homo sapiens 3-bromo-11-hydroxy-2-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione
0.00706
-
-
 Homo sapiens 11-hydroxy-2-phenyl-4H-naphtho[2,3-h]chromene-4,7,12-trione
0.00715
-
-
 Homo sapiens 11-[2-(dimethylamino)ethoxy]-2-methyl-4H-naphtho[2,3-h]chromene-4,7,12-trione
0.0091
-
-
 Homo sapiens 11-hydroxy-2-methyl-8-nitro-4H-naphtho[2,3-h]chromene-4,7,12-trione
0.0295
-
-
 Homo sapiens topopyrone C
0.16
-
-
 Homo sapiens 4-hydroxy-5-methoxy-1-nitroanthracene-9,10-dione