Literature summary for 5.6.2.1 extracted from

Douarre, C.; Sourbier, C.; Dalla Rosa, I.; Brata Das, B.; Redon, C.E.; Zhang, H.; Neckers, L.; Pommier, Y.
Mitochondrial topoisomerase I is critical for mitochondrial integrity and cellular energy metabolism (2012), PLoS ONE, 7, e41094.

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Protein Variants

Protein Variants	Comment	Organism
additional information	generation of mutant cells that are deficient in mitochondrial isozyme Top1mt, i.e. the Top1mt-/- cell line	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	isozymes Top1mt, Top3alpha and a truncated form of Top2beta	Homo sapiens	5739	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Synonyms

Synonyms	Comment	Organism
Topoisomerase I	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	mitochondria are dysfunctional in mitochondrial isozyme Top1mt-deficient cells, the ATP content is 2fold less in Top1mt-/- compared to wild-type cells, confirming dysfunctional respiratory chain in Top1mt-/- cells. The mutant cells also show Increases of fatty acid oxidation and lipogenesis. Isozyme Top1mt deficiency leads to increased glycolytic activity	Homo sapiens
physiological function	c-myc is a key regulator for nuclear-encoded mitochondrial genes including mitochondrial isozyme TOP1mt	Homo sapiens

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Release 2023.1 (January 2023)