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Literature summary for 5.6.2.1 extracted from

  • Barth, S.W.; Briviba, K.; Watzl, B.; Jaeger, N.; Marko, D.; Esselen, M.
    In vivo bioassay to detect irinotecan-stabilized DNA/topoisomerase I complexes in rats (2010), Biotechnol. J., 5, 321-327.
    View publication on PubMed
Search for more literature for 5.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
irinotecan topoisomerase I forms in vivo complexes with DNA substrates, the complexes are stabilized by irinotecan, which has DNA strand breaking ability, it leads to topisomerase poisoning and DNA damage, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Rattus norvegicus 5634
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus topoisomerase I forms in vivo complexes with DNA substrates, the complexes are stabilized by irinotecan, which has DNA strand breaking ability, it leads to topisomerase poisoning and DNA damage, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Rattus norvegicus
-
colonic mucosa
-
 Rattus norvegicus
-
duodenum
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-
mucosa
-
 Rattus norvegicus
-
stomach
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information topoisomerase I forms in vivo complexes with DNA substrates, the complexes are stabilized by irinotecan, which has DNA strand breaking ability, it leads to topisomerase poisoning and DNA damage, overview Rattus norvegicus ?
-
 ?

Synonyms

Synonyms Comment Organism
Topoisomerase I
-
 Rattus norvegicus