Literature summary for 5.6.2.1 extracted from

Cinelli, M.A.; Morrell, A.; Dexheimer, T.S.; Scher, E.S.; Pommier, Y.; Cushman, M.
Design, synthesis, and biological evaluation of 14-substituted aromathecins as topoisomerase I inhibitors (2008), J. Med. Chem., 51, 4609-4619.

Inhibitors

Inhibitors	Comment	Organism
14-(1-imidazolylmethyl)-2H-5,11a-diazadibenzo[b,h]fluoren-11-one	-	Homo sapiens
14-(1-morpholinomethyl)-2H-5,11a-diazadibenzo[b,h]fluoren-11-one	-	Homo sapiens
14-(3-aminopropyl)-12H-5,11a-diazadibenzo[b,h]fluoren-11-one dihydrochloride	-	Homo sapiens
14-(3-N-ethanolaminopropyl)-12H-5,11a-diazadibenzo[b,h]fluoren-11-one trifluoroacetate	-	Homo sapiens
14-(N,N-dimethylaminomethyl)-2H-5,11a-diazadibenzo[b,h]fluoren-11-one	-	Homo sapiens
14-(N-ethanolaminomethyl)-2H-5,11a-diazadibenzo[b,h]fluoren-11one	-	Homo sapiens
14-aminomethyl-12H-5,11a-diazadibenzo[b,h]fluoren-11-one dihydrochloride	-	Homo sapiens
14-chloromethyl-12H-5,11a-diazadibenzo[b,h]fluoren-11-one	-	Homo sapiens
14-[(1-imidazolyl)propylaminomethyl]-12H-5,11a-diazadibenzo[b,h]fluoren-11-one	-	Homo sapiens
14-[1-(N-methylpiperazinylmethyl)]-2H-5,11a-diazadibenzo[b,h]fluoren-11-one	-	Homo sapiens
14-[3(1-morpholinopropyl)]-12H-5,11a-diazadibenzo[b,h]fluoren-11-one trifluoroacetate	-	Homo sapiens
14-[3-(1-imidazolylpropyl)]-12H-5,11a-diazadibenzo[b,h]fluoren-11-one trifluoroacetate	-	Homo sapiens
14-[3-(N,N-dimethylaminopropyl)]-12H-5,11a-diazadibenzo[b,h]fluoren-11-one trifluoroacetate	-	Homo sapiens
14-[N-(S)-3-hydroxypyrrolidinomethyl]-12H-5,11a diazadibenzo[b,h]fluoren-11-one	-	Homo sapiens
22-hydroxyacuminatine	-	Homo sapiens
camptothecin	-	Homo sapiens
dimethoxyaromathecin	-	Homo sapiens
indenoisoquinoline	-	Homo sapiens
NSC 314622	-	Homo sapiens
rosettacin	-	Homo sapiens

Organism	UniProt	Comment	Textmining
Homo sapiens	P11387	-	-

Source Tissue	Comment	Organism	Textmining
DU-145 cell	human prostate tumor cell	Homo sapiens	-
HCT-116 cell	human colon tumor cell	Homo sapiens	-
HOP-62 cell	human lung tumor cell	Homo sapiens	-
MDA-MB-435 cell	MDA-MB-435MGM cell	Homo sapiens	-
additional information	each inhibitor compound is evaluated against approximately 60 cell lines originating from various human tumors	Homo sapiens	-
OVCAR-3 cell	human ovarian tumor cell	Homo sapiens	-
SF-539 cell	human CNS tumor cell	Homo sapiens	-
SN-12C cell	human renal tumor cell	Homo sapiens	-
UACC-62 cell	human melanoma tumor cell	Homo sapiens	-

Synonyms	Comment	Organism
Top1	-	Homo sapiens
Topoisomerase I	-	Homo sapiens

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
additional information	-	GI50 values (the concentrations corresponding to 50% growth inhibition) for the different inhibitors with the different cell lines listed	Homo sapiens	additional information