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Literature summary for 5.6.2.1 extracted from

  • Losasso, C.; Cretaio, E.; Fiorani, P.; DAnnessa, I.; Chillemi, G.; Benedetti, P.
    A single mutation in the 729 residue modulates human DNA topoisomerase IB DNA binding and drug resistance (2008), Nucleic Acids Res., 36, 5635-5644.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Saccharomyces cerevisiae strain EKY3 Homo sapiens

Protein Variants

Protein Variants Comment Organism
T729A mutations that confer camptothecin resistance, but do not interact directly with the drug or the DNA, oligonucleotide-directed mutagenesis Homo sapiens
T729E camptothecin resistance, remarkable defect in DNA binding, oligonucleotide-directed mutagenesis Homo sapiens
T729K camptothecin resistance, oligonucleotide-directed mutagenesis Homo sapiens
T729P oligonucleotide-directed mutagenesis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
camptothecin
-
 Homo sapiens
topotecan
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
phosphocellulose chromatography Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
negatively supercoiled DNA
-
 Homo sapiens relaxed DNA
-
 ?

Synonyms

Synonyms Comment Organism
hTop1p
-
 Homo sapiens
human DNA topoisomerase I
-
 Homo sapiens