Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,4-di(furan-2-yl)-5H-chromeno[4,3-b]pyridine | 46.4% inhibition at 0.1 mM# | Homo sapiens | |
2,4-di(pyridin-2-yl)-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
2,4-di(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
2,4-di(thiophen-3-yl)-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
2,4-diphenyl-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
2-(furan-2-yl)-4-(pyridin-2-yl)-5H-chromeno[4,3-b]pyridine | 11.5% inhibition at 0.1 mM | Homo sapiens | |
2-(furan-2-yl)-4-(pyridin-3-yl)-5H-chromeno[4,3-b]pyridine | 41.6% inhibition at 0.1 mM | Homo sapiens | |
2-(furan-2-yl)-4-(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
2-(furan-2-yl)-4-phenyl-5H-chromeno[4,3-b]pyridine | 4.9% inhibition at 0.1 mM | Homo sapiens | |
2-(pyridin-2-yl)-4-(pyridin-3-yl)-5H-chromeno[4,3-b]pyridine | 2.6% inhibition at 0.1 mM | Homo sapiens | |
2-(pyridin-2-yl)-4-(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | 48.2% inhibition at 0.1 mM | Homo sapiens | |
2-phenyl-4-(pyridin-2-yl)-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
2-phenyl-4-(pyridin-3-yl)-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
2-phenyl-4-(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
2-phenyl-4-(thiophen-3-yl)-5H-chromeno[4,3-b]pyridine | 3.6% inhibition at 0.1 mM | Homo sapiens | |
4-(furan-2-yl)-2-(pyridin-2-yl)-5H-chromeno[4,3-b]pyridine | 4.4% inhibition at 0.1 mM | Homo sapiens | |
4-(furan-2-yl)-2-(thiophen-2-yl)-5H-chromeno [4,3-b]pyridine | 9.2% inhibition at 0.1 mM | Homo sapiens | |
4-(furan-2-yl)-2-(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
4-(furan-2-yl)-2-phenyl-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
4-(furan-3-yl)-2-(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
4-(furan-3-yl)-2-phenyl-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
4-(pyridin-2-yl)-2-(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | - |
Homo sapiens | |
4-(pyridin-2-yl)-2-(thiophen-3-yl)-5H-chromeno[4,3-b]pyridine | 3.3% inhibition at 0.1 mM | Homo sapiens | |
4-phenyl-2-(pyridin-2-yl)-5H-chromeno[4,3-b]pyridine | 3.1% inhibition at 0.1 mM | Homo sapiens | |
4-phenyl-2-(thiophen-2-yl)-5H-chromeno[4,3-b]pyridine | 5.5% inhibition at 0.1 mM | Homo sapiens | |
camptothecin | - |
Homo sapiens | |
etoposide | - |
Homo sapiens | |
additional information | synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase II inhibitory activity, cytotoxicity, and structure-activity relationship, overview. 2-Furyl or 2-thienyl at 2- or 4-position of central pyridine is crucial in displaying topo I or II inhibitory activity and cytotoxicity. No inhibition by 18, 19,20, 21, 22, 23, 25, 29, 32, 33, and 35 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I inhibitory activity, cytotoxicity, and structure-activity relationship, overview. 2-Furyl or 2-thienyl at 2- or 4-position of central pyridine is crucial in displaying topo I or II inhibitory activity and cytotoxicity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | DNA topo I | Homo sapiens | - |
DU-145 cell | a prostate tumor cell line | Homo sapiens | - |
HCT-15 cell | a colorectal adenocarcinoma cell line | Homo sapiens | - |
HeLa cell | - |
Homo sapiens | - |
HL-60 cell | a myeloid leukemic tumor cell line | Homo sapiens | - |
MDA-MB-231 cell | a breast tumor cell line | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | substrate for DNA topo I is pBR322 plasmid DNA | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA topo I | - |
Homo sapiens |
Topoisomerase I | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.9 | - |
assay at | Homo sapiens |