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Literature summary for 5.6.2.1 extracted from

  • Cheng, B.; Annamalai, T.; Sorokin, E.; Abrenica, M.; Aedo, S.; Tse-Dinh, Y.C.
    Asp-to-Asn substitution at the first position of the DxD TOPRIM motif of recombinant bacterial topoisomerase I is extremely lethal to E. coli (2009), J. Mol. Biol., 385, 558-567.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli. High-copy-number plasmid expressing YpTOP-D117N can not be maintained in Escherichia coli without a second-site mutation Yersinia pestis

Protein Variants

Protein Variants Comment Organism
C737Y site-directed mutagenesis Yersinia pestis
D111N EcTOP 67 kDa N-terminal fragment, site-directed mutagenesis Escherichia coli
D113N EcTOP, site-directed mutagenesis Escherichia coli
D116N/W866L site-directed mutagenesis Yersinia pestis
D117N site-directed mutagenesis Yersinia pestis
D117N/C608G site-directed mutagenesis Yersinia pestis
D117N/C668F site-directed mutagenesis Yersinia pestis
D117N/C737Y site-directed mutagenesis Yersinia pestis
D119N site-directed mutagenesis Yersinia pestis
D80N/G94S/D117N YpTOP39 has D80N, G94S, and D117N mutations Yersinia pestis
E121Q site-directed mutagenesis Yersinia pestis
G116S EcTOP 67 kDa N-terminal fragment, site-directed mutagenesis Escherichia coli
G122S site-directed mutagenesis Yersinia pestis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Escherichia coli
Mg2+
-
Yersinia pestis

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Yersinia pestis Q7CIL8
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli
-
Yersinia pestis

Synonyms

Synonyms Comment Organism
EcTOP
-
Escherichia coli
Topoisomerase I
-
Escherichia coli
Topoisomerase I
-
Yersinia pestis
YpTOP
-
Yersinia pestis