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Literature summary for 5.6.2.1 extracted from

  • Li, Z.; Zhai, F.; Zhao, L.; Guo, Q.; You, Q.
    Design and synthesis of N-methylmaleimide indolocarbazole bearing modified 2-acetamino acid moieties as Topoisomerase I inhibitors (2009), Bioorg. Med. Chem. Lett., 19, 406-409.
    View publication on PubMed
Search for more literature for 5.6.2.1

Application

Application Comment Organism
drug development inhibitors promising lead compounds of novel antitumor drugs Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)-N-[2-methyl-1-(morpholin-4-ylcarbonyl)propyl]acetamide
-
 Homo sapiens
2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)-N-[3-methyl-1-[(4-methylpiperazin-1-yl)carbonyl]butyl]acetamide
-
 Homo sapiens
camptothecin
-
 Homo sapiens
JDC-108
-
 Homo sapiens
methyl N-[(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)acetyl]glycinate
-
 Homo sapiens
N-[1-benzyl-2-(4-ethylpiperazin-1-yl)-2-oxoethyl]-2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)acetamide
-
 Homo sapiens
N-[1-[(4-ethylpiperazin-1-yl)carbonyl]-3-methylbutyl]-2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)acetamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-549 cell
-
 Homo sapiens
-
BEL-7402 cell
-
 Homo sapiens
-
HCT-8 cell
-
 Homo sapiens
-
HT-29 cell
-
 Homo sapiens
-
MCF-7 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Topo I
-
 Homo sapiens
Topoisomerase I
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00109
-
 for HCT-8 cells Homo sapiens N-[1-benzyl-2-(4-ethylpiperazin-1-yl)-2-oxoethyl]-2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)acetamide
0.00126
-
 for HT-29 cells Homo sapiens 2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)-N-[3-methyl-1-[(4-methylpiperazin-1-yl)carbonyl]butyl]acetamide
0.00184
-
 for A549 cells Homo sapiens 2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)-N-[3-methyl-1-[(4-methylpiperazin-1-yl)carbonyl]butyl]acetamide
0.00186
-
 for A549 cells Homo sapiens N-[1-benzyl-2-(4-ethylpiperazin-1-yl)-2-oxoethyl]-2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)acetamide
0.00191
-
 for Bel-7402 cells Homo sapiens N-[1-benzyl-2-(4-ethylpiperazin-1-yl)-2-oxoethyl]-2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)acetamide
0.00191
-
 for MCF-7 cells Homo sapiens N-[1-benzyl-2-(4-ethylpiperazin-1-yl)-2-oxoethyl]-2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)acetamide
0.00194
-
 for MCF-7 cells Homo sapiens 2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)-N-[3-methyl-1-[(4-methylpiperazin-1-yl)carbonyl]butyl]acetamide
0.00213
-
 for A549 cells Homo sapiens methyl N-[(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)acetyl]glycinate
0.00223
-
 for Bel-7402 cells Homo sapiens 2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)-N-[3-methyl-1-[(4-methylpiperazin-1-yl)carbonyl]butyl]acetamide
0.00223
-
 for MCF-7 cells Homo sapiens methyl N-[(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)acetyl]glycinate
0.00244
-
 for MCF-7 cells Homo sapiens N-[1-[(4-ethylpiperazin-1-yl)carbonyl]-3-methylbutyl]-2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)acetamide
0.00266
-
 for HT-29 cells Homo sapiens 2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)-N-[2-methyl-1-(morpholin-4-ylcarbonyl)propyl]acetamide
0.00288
-
 for HT-29 cells Homo sapiens N-[1-benzyl-2-(4-ethylpiperazin-1-yl)-2-oxoethyl]-2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)acetamide
0.00288
-
 for HT-29 cells Homo sapiens methyl N-[(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)acetyl]glycinate
0.00348
-
 for HT-29 cells Homo sapiens N-[1-[(4-ethylpiperazin-1-yl)carbonyl]-3-methylbutyl]-2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)acetamide
0.00511
-
 for A549 cells Homo sapiens 2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)-N-[2-methyl-1-(morpholin-4-ylcarbonyl)propyl]acetamide
0.00668
-
 for Bel-7402 cells Homo sapiens JDC-108
0.00744
-
 for HT-29 cells Homo sapiens JDC-108
0.00794
-
 for A549 cells Homo sapiens N-[1-[(4-ethylpiperazin-1-yl)carbonyl]-3-methylbutyl]-2-(6-methyl-5,7-dioxo-5,6,7,13-tetrahydro-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-12-yl)acetamide