Literature summary for 5.6.2.1 extracted from

Cheng, B.; Shukla, S.; Vasunilashorn, S.; Mukhopadhyay, S.; Tse-Dinh, Y.C.
Bacterial cell killing mediated by topoisomerase I DNA cleavage activity (2005), J. Biol. Chem., 280, 38489-38495.

Search for more literature for 5.6.2.1

Cloned(Commentary)

Cloned (Comment)	Organism
expression of mutant enzymes in Escherichia coli	Yersinia pestis

Protein Variants

Protein Variants	Comment	Organism
A383P	mutant enzyme has wild-type levels of relaxation and cleavage activity	Yersinia pestis
G116S	mutant enzyme shows more than 400fold loss of relaxation activity	Yersinia pestis
G122S	mutant enzyme shows more than 400fold loss of relaxation activity	Yersinia pestis
M326V	mutant enzyme has wild-type levels of relaxation and cleavage activity	Yersinia pestis

Organism

Organism	UniProt	Comment	Textmining
Yersinia pestis	-	-	-

Synonyms

Synonyms	Comment	Organism
YTOP	-	Yersinia pestis

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Release 2023.1 (January 2023)