Inhibitors | Comment | Organism | Structure |
---|---|---|---|
11-hexyl-5-(4-methylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinolin-11-ol | - |
Homo sapiens | |
11-methyl-5-(4-methylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinolin-11-ol | - |
Homo sapiens | |
2,3-dimethoxy-6-methyl-5H-[1,3]dioxolo[5,6]indeno[1,2-c]isoquinoline-5,12(6H)-dione | i.e. NSC 314622 | Homo sapiens | |
3-arylisoquinoline | - |
Homo sapiens | |
5-(4-ethylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinolin-11-ol | - |
Homo sapiens | |
5-(4-ethylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinolin-11-one | - |
Homo sapiens | |
5-(4-ethylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinoline | - |
Homo sapiens | |
5-(4-methyl-1,4-diazepan-1-yl)-11H-indeno[1,2-c]isoquinolin-11-one | - |
Homo sapiens | |
5-(4-methyl-1,4-diazepan-1-yl)-11H-indeno[1,2-c]isoquinoline | - |
Homo sapiens | |
5-(4-methylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinolin-11-ol | - |
Homo sapiens | |
5-(4-methylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinolin-11-one | - |
Homo sapiens | |
5-(4-methylpiperazin-1-yl)-11H-indeno[1,2-c]isoquinoline | - |
Homo sapiens | |
5-(butylamino)-11H-indeno[1,2-c]isoquinolin-11-one | - |
Homo sapiens | |
5-(morpholin-4-yl)-11H-indeno[1,2-c]isoquinolin-11-ol | - |
Homo sapiens | |
5-(morpholin-4-yl)-11H-indeno[1,2-c]isoquinolin-11-one | - |
Homo sapiens | |
5-(morpholin-4-yl)-11H-indeno[1,2-c]isoquinolin-11-yl acetate | - |
Homo sapiens | |
5-(morpholin-4-yl)-11H-indeno[1,2-c]isoquinoline | - |
Homo sapiens | |
5-(piperazin-1-yl)-11H-indeno[1,2-c]isoquinolin-11-one | - |
Homo sapiens | |
indeno[1,2-c]isoquinolinone | - |
Homo sapiens | |
additional information | various 5-amino group-substituted indeno[1,2-c]isoquinolines display potent topoisomerase I inhibitory activity as well as cytotoxicities against five different human tumor cell lines. Molecular modelling and docking using protein structure PDB ID 1SC7 | Homo sapiens | |
N-butyl-11H-indeno[1,2-c]isoquinolin-5-amine | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-549 cell | - |
Homo sapiens | - |
Col-2 cell | - |
Homo sapiens | - |
HL-60 cell | - |
Homo sapiens | - |
HT-1080 cell | - |
Homo sapiens | - |
SNU-638 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | substrate is supercoiled pBR322 DNA | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Topoisomerase I | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |