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Literature summary for 5.6.2.1 extracted from

  • Chua, S.; Quek, N.; Li, M.; Ng, M.; Yuan, W.; Chua, M.; Guo, J.; Koh, L.; Ye, R.; Li, T.
    Nick-containing oligonucleotides as human topoisomerase I inhibitors (2009), Bioorg. Med. Chem. Lett., 19, 618-623.
    View publication on PubMed
Search for more literature for 5.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
nick-containing oligonucleotides inhibit DNA substrate relaxation. Synthesis of and enzyme inhibition by a series of oligonucleotides with various lengths that contain nick and topoisomerase I-binding sites, sequences, overview. The position of the nick as well as the length of the oligonucleotides are crucial factors for the inhibition of the nuclear enzyme Homo sapiens
nick-containing oligonucleotides s inhibit DNA substrate relaxation. Synthesis of and enzyme inhibition by a series of oligonucleotides with various lengths that contain nick and topoisomerase I-binding sites, sequences, overview. The position of the nick as well as the length of the oligonucleotides are crucial factors for the inhibition of the nuclear enzyme Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetic analysis, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information substrate is supercoiled pBR322 DNA Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Topoisomerase I
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000063
-
-
 Homo sapiens nick-containing oligonucleotides
0.0000063
-
-
 Homo sapiens nick-containing oligonucleotide