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Literature summary for 5.6.2.1 extracted from
- Reconstitution and functional characterization of the unusual bi-subunit type I DNA topoisomerase from Leishmania donovani (2004), FEBS Lett., 565, 81-88.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in Escherichia coli BL21(DE3) | Leishmania donovani |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| kinetoplast | - |
Leishmania donovani | 20023 | - |
| nucleus | - |
Leishmania donovani | 5634 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 29000 | - |
1 * 29000 + 1 * 73000, LdTOP1L (large subunit) and LdTOP1S (small subunit) form a direct 1:1 heterodimer complex through protein-protein interaction, SDS-PAGE | Leishmania donovani |
| 73000 | - |
1 * 29000 + 1 * 73000, LdTOP1L (large subunit) and LdTOP1S (small subunit) form a direct 1:1 heterodimer complex through protein-protein interaction, SDS-PAGE | Leishmania donovani |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Leishmania donovani | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Leishmania donovani |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 1 * 29000 + 1 * 73000, LdTOP1L (large subunit) and LdTOP1S (small subunit) form a direct 1:1 heterodimer complex through protein-protein interaction, SDS-PAGE | Leishmania donovani |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| LdTOP1L | large subunit | Leishmania donovani |
| LdTOP1S | small subunit | Leishmania donovani |
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Release 2023.1 (January 2023)
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