Literature summary for 5.6.2.1 extracted from

Nabiev, I.; Chourpa, I.; Riou, J.F.; Nguyen, C.H.; Lavelle, F.; Manfait, M.
Molecular interactions of DNA-topoisomerase I and II inhibitor with DNA and topoisomerases and in ternary complexes: binding modes and biological effects for intoplicine derivatives (1994), Biochemistry, 33, 9013-9023.

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Inhibitors

Inhibitors	Comment	Organism	Structure
intoplicine	molecular interactions with DNA and topoisomerases and in ternary complexes, binding modes and biological effects of intoplicine derivatives	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	calf	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
thymus	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
supercoiled DNA	relaxation	Bos taurus	relaxed closed circular DNA	-	?

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Release 2023.1 (January 2023)