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Literature summary for 5.6.2.1 extracted from

  • Eisenreich, A.; Bogdanov, V.Y.; Zakrzewicz, A.; Pries, A.; Antoniak, S.; Poller, W.; Schultheiss, H.P.; Rauch, U.
    Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor in human endothelial cells (2009), Circ. Res., 104, 589-599.
    View publication on PubMed
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Protein Variants

Protein Variants Comment Organism
additional information expression of specific siRNA inhibits the enzyme and elicits distinct changes in TF biosynthesis in TNF-alpha-stimulated endothelial cells, which impact endothelial procoagulant activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor, TF, via phosphorylation of serine/arginine-rich proteins. Selective inhibition of Cdc2-like kinases and DNA topoisomerase I elicite distinct changes in TF biosynthesis in TNF-alpha-stimulated endothelial cells, which impact endothelial procoagulant activity, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
endothelial cell
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 Homo sapiens
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umbilical vein endothelial cell
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 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor, TF, via phosphorylation of serine/arginine-rich proteins. Selective inhibition of Cdc2-like kinases and DNA topoisomerase I elicite distinct changes in TF biosynthesis in TNF-alpha-stimulated endothelial cells, which impact endothelial procoagulant activity, overview Homo sapiens ?
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 ?

General Information

General Information Comment Organism
malfunction selective inhibition of Cdc2-like kinases and DNA topoisomerase I elicite distinct changes in TF biosynthesis in TNF-alpha-stimulated endothelial cells, which impact endothelial procoagulant activity, overview Homo sapiens
physiological function Cdc2-like kinases and DNA topoisomerase I regulate alternative splicing of tissue factor, TF,via phosphorylation of serine/arginine-rich proteins Homo sapiens