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Literature summary for 5.6.2.1 extracted from

  • Arlt, M.F.; Glover, T.W.
    Inhibition of topoisomerase I prevents chromosome breakage at common fragile sites (2010), DNA Repair, 9, 678-689.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 5.6.2.1

Inhibitors

Inhibitors Comment Organism Structure
camptothecin
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
chromosome
-
 Homo sapiens 5694
-
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
UML-49 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Topoisomerase I
-
 Homo sapiens

General Information

General Information Comment Organism
additional information inhibition of topoisomerase I prevents chromosome breakage at common fragile sites. Polymerase-helicase uncoupling is a key initial event in this process Homo sapiens