Literature summary for 5.6.2.1 extracted from

Zhai, B.; Shuai, L.; Yang, L.; Weng, X.; Wu, L.; Wang, S.; Tian, T.; Wu, X.; Zhou, X.; Zheng, C.
Octa-substituted anionic porphyrins: topoisomerase I inhibition and tumor cell apoptosis induction (2008), Bioconjug. Chem., 19, 1535-1542.

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Inhibitors

Inhibitors	Comment	Organism	Structure
4,4',4'',4'''-porphyrin-5,10,15,20-tetrayltetrabenzoic acid	-	Homo sapiens
beta-octabromo-meso-tetra(4-carboxyl)phenyl porphyrin	-	Homo sapiens
beta-octaphenyl-meso-tetra(4-carboxyl)phenyl porphyrin	-	Homo sapiens
camptothecin	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
SGC-7901 cell	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Topo I	-	Homo sapiens
Topoisomerase I	-	Homo sapiens

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00234	-	-	Homo sapiens	beta-octabromo-meso-tetra(4-carboxyl)phenyl porphyrin
0.0034	-	-	Homo sapiens	beta-octaphenyl-meso-tetra(4-carboxyl)phenyl porphyrin
0.01175	-	-	Homo sapiens	4,4',4'',4'''-porphyrin-5,10,15,20-tetrayltetrabenzoic acid

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Release 2023.1 (January 2023)