Reference on EC 3.4.24.69 - bontoxilysin
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Eisel, U.; Jarusch, W.; Goretzki, K.; Henschen, A.; Engels, J.; Weller, U.; Hudel, M.; Habermann, E.; Niemann, H.
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Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin
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Clostridium baratii, Clostridium botulinum, Clostridium butyricum
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Clostridium botulinum, Clostridium sp.
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Clostridium botulinum
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Clostridium botulinum
Hauser, D.; Eklund, M.W.; Kurazono, H.; Binz, T.; Niemann, H.; Gill, D.M.; Boquet, P.; Popoff, M.R.
Nucleotide sequence of Clostridium botulinum C1 neurotoxin
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Clostridium botulinum
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Separation, purification, partial characterization and comparison of the heavy and light chains of botulinum neurotoxin types A, B, and E
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Clostridium botulinum
Thompson, D.E.; Brehm, J.K.; Oultram, J.D.; Swinfield, T.J.; Shone, C.C.; Atkinson, T.; Melling, J.; Minton, N.P.
The complete amino acid sequence of the Clostridium botulinum type A neurotoxin, deduced by nucleotide sequence analysis of the encoding gene
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1990
Clostridium botulinum
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The complete sequence of botulinum neurotoxin type A and comparison with other clostridial neurotoxins
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Clostridium botulinum
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Isolation and characterization of the botulinum neurotoxins
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Clostridium sp.
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Schiavo, G.; Santucci, A.; DasGupta, B.R.; Mehta, P.P.; Jontes, J.; Benfenati, F.; Wilson, M.C.; Montecucco, C.
Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds
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335
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Clostridium botulinum
Schiavo, G.; Rossetto, O.; Catsicas, S.; Polverino de Laureto, P.; DasGupta, B.R.; Benfenati, F.; Montecucco, C.
Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E
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268
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Clostridium sp., Clostridium sp. F
Schiavo, G.; Shone, C.C.; Rossetto, O.; Alexander, F.C.G.; Montecucco, C.
Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synaptobrevin
J. Biol. Chem.
268
11516-11519
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Clostridium sp., Clostridium sp. F
Schiavo, G.; Malizio, C.; Trimble, W.S.; Polverino de Laureto, P.; Milan, G.; Sugiyama, H.; Johnson, E.A.; Montecucco, C.
Botulinum G neurotoxin cleaves VAMP/synaptobrevin at a single Ala-Ala peptide bond
J. Biol. Chem.
269
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1994
Clostridium botulinum, Clostridium botulinum type G
Burnett, J.C.; Schmidt, J.J.; Stafford, R.G.; Panchal, R.G.; Nguyen, T.L.; Hermone, A.R.; Vennerstrom, J.L.; McGrath, C.F.; Lane, D.J.; Sausville, E.A.; Zaharevitz, D.W.; Gussio, R.; Bavari, S.
Novel small molecule inhibitors of botulinum neurotoxin A metalloprotease activity
Biochem. Biophys. Res. Commun.
310
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Clostridium botulinum
Li, L.; Singh, B.R.
Role of zinc binding in type A botulinum neurotoxin light chain's toxic structure
Biochemistry
39
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2000
Clostridium botulinum
Simpson, L.L.
Identification of the characteristics that underlie botulinum toxin potency: implications for designing novel drugs
Biochimie
82
943-953
2000
Clostridium baratii, Clostridium botulinum, Clostridium butyricum
Washbourne, P.; Pellizzari, R.; Baldini, G.; Wilson, M.C.; Montecucco, C.
Botulinum neurotoxin types A and E require the SNARE motif in SNAP-25 for proteolysis
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418
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1997
Clostridium botulinum
Adler, M.; Nicholson, J.D.; Cornille, F.; Hackley, B.E., Jr.
Efficacy of a novel metalloprotease inhibitor on botulinum neurotoxin B activity
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429
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Clostridium botulinum
Schmidt, J.J.; Stafford, R.G.; Bostian, K.A.
Type A botulinum neurotoxin proteolytic activity: development of competitive inhibitors and implications for substrate specificity at the S1' binding subsite
FEBS Lett.
435
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1998
Clostridium botulinum
Schmidt, J.J.; Stafford, R.G.
A high-affinity competitive inhibitor of type A botulinum neurotoxin protease activity
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532
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2002
Clostridium botulinum
Garcia, G.E.; Moorad, D.R.; Gordon, R.K.
Buforin I, a natural peptide, inhibits botulinum neurotoxin B activity in vitro
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19 Suppl 1
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1999
Clostridium botulinum
Anne, C.; Turcaud, S.; Quancard, J.; Teffo, F.; Meudal, H.; Fournie-Zaluski, M.C.; Roques, B.P.
Development of potent inhibitors of botulinum neurotoxin type B
J. Med. Chem.
46
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2003
Clostridium botulinum
Schmidt, J.J.; Bostian, K.A.
Endoproteinase activity of type A botulinum neurotoxin: substrate requirements and activation by serum albumin
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1997
Clostridium botulinum
Antharavally, B.S.; DasGupta, B.R.
Covalent structure of botulinum neurotoxin type B; location of sulfhydryl groups and disulfide bridge and identification of C-termini of light and heavy chains
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1998
Clostridium botulinum
Sagane, Y.; Watanabe, T.; Kouguchi, H.; Sunagawa, H.; Inoue, K.; Fujinaga, Y.; Oguma, K.; Ohyama, T.
Dichain structure of botulinum neurotoxin: identification of cleavage sites in types C, D, and F neurotoxin molecules
J. Protein Chem.
18
885-892
1999
Clostridium botulinum (P18640), Clostridium botulinum (P19321), Clostridium botulinum (P30996), Clostridium botulinum, Clostridium botulinum CB16 (P19321), Clostridium botulinum Stockholm (P18640)
Ahmed, S.A.; Byrne, M.P.; Jensen, M.; Hines, H.B.; Brueggemann, E.; Smith, L.A.
Enzymatic autocatalysis of botulinum A neurotoxin light chain
J. Protein Chem.
20
221-231
2001
Clostridium botulinum
Li, L.; Singh, B.R.
High-level expression, purification, and characterization of recombinant type A botulinum neurotoxin light chain
Protein Expr. Purif.
17
339-344
1999
Clostridium botulinum
Raffestin, S.; Marvaud, J.C.; Cerrato, R.; Dupuy, B.; Popoff, M.R.
Organization and regulation of the neurotoxin genes in Clostridium botulinum and Clostridium tetani
Anaerobe
10
93-100
2004
Clostridium botulinum
Agarwal, R.; Binz, T.; Swaminathan, S.
Structural analysis of botulinum neurotoxin serotype F light chain: implications on substrate binding and inhibitor design
Biochemistry
44
11758-11765
2005
Clostridium botulinum
Schmidt, J.J.; Stafford, R.G.
Botulinum neurotoxin serotype F: identification of substrate recognition requirements and development of inhibitors with low nanomolar affinity
Biochemistry
44
4067-4073
2005
Clostridium botulinum
Agarwal, R.; Binz, T.; Swaminathan, S.
Analysis of active site residues of botulinum neurotoxin E by mutational, functional, and structural studies: Glu335Gln is an apoenzyme
Biochemistry
44
8291-8302
2005
Clostridium botulinum
Arndt, J.W.; Yu, W.; Bi, F.; Stevens, R.C.
Crystal structure of botulinum neurotoxin type G light chain: serotype divergence in substrate recognition
Biochemistry
44
9574-9580
2005
Clostridium botulinum
Arndt, J.W.; Chai, Q.; Christian, T.; Stevens, R.C.
Structure of botulinum neurotoxin type D light chain at 1.65 A resolution: repercussions for VAMP-2 substrate specificity
Biochemistry
45
3255-3262
2006
Clostridium botulinum
Montecucco, C.; Molgo, J.
Botulinal neurotoxins: revival of an old killer
Curr. Opin. Pharmacol.
5
274-279
2005
Clostridium botulinum
Kirma, N.; Ferreira, J.L.; Baumstark, B.R.
Characterization of six type A strains of Clostridium botulinum that contain type B toxin gene sequences
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231
159-164
2004
Clostridium botulinum
Gessler, F.
A new scaleable method for the purification of botulinum neurotoxin type E
J. Biotechnol.
119
204-211
2005
Clostridium botulinum
Bade, S.; Rummel, A.; Reisinger, C.; Karnath, T.; Ahnert-Hilger, G.; Bigalke, H.; Binz, T.
Botulinum neurotoxin type D enables cytosolic delivery of enzymatically active cargo proteins to neurones via unfolded translocation intermediates
J. Neurochem.
91
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2004
Clostridium botulinum
Couesnon, A.; Raffestin, S.; Popoff, M.R.
Expression of botulinum neurotoxins A and E, and associated non-toxin genes, during the transition phase and stability at high temperature: analysis by quantitative reverse transcription-PCR
Microbiology
152
759-770
2006
Clostridium botulinum, Clostridium botulinum type A
Breidenbach, M.A.; Brunger, A.T.
Substrate recognition strategy for botulinum neurotoxin serotype A
Nature
432
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2004
Clostridium botulinum
Singh, B.R.
Botulinum neurotoxin structure, engineering, and novel cellular trafficking and targeting
Neurotox. Res.
9
73-92
2006
Clostridium botulinum
Segelke, B.; Knapp, M.; Kadkhodayan, S.; Balhorn, R.; Rupp, B.
Crystal structure of Clostridium botulinum neurotoxin protease in a product-bound state: Evidence for noncanonical zinc protease activity
Proc. Natl. Acad. Sci. USA
101
6888-6893
2004
Clostridium botulinum
Zhou, Y.; Singh, B.R.
Cloning, high-level expression, single-step purification, and binding activity of His6-tagged recombinant type B botulinum neurotoxin heavy chain transmembrane and binding domain
Protein Expr. Purif.
34
8-16
2004
Clostridium botulinum
Agarwal, R.; Eswaramoorthy, S.; Kumaran, D.; Dunn, J.J.; Swaminathan, S.
Cloning, high level expression, purification, and crystallization of the full length Clostridium botulinum neurotoxin type E light chain
Protein Expr. Purif.
34
95-102
2004
Clostridium botulinum
Sharma, S.; Zhou, Y.; Singh, B.R.
Cloning, expression, and purification of C-terminal quarter of the heavy chain of botulinum neurotoxin type A
Protein Expr. Purif.
45
288-295
2006
Clostridium botulinum (P10845)
Dux, M.P.; Barent, R.; Sinha, J.; Gouthro, M.; Swanson, T.; Barthuli, A.; Inan, M.; Ross, J.T.; Smith, L.A.; Smith, T.J.; Webb, R.; Loveless, B.; Henderson, I.; Meagher, M.M.
Purification and scale-up of a recombinant heavy chain fragment C of botulinum neurotoxin serotype E in Pichia pastoris GS115
Protein Expr. Purif.
45
359-367
2006
Clostridium botulinum
Hasegawa, K.; Watanabe, T.; Sato, H.; Sagane, Y.; Mutoh, S.; Suzuki, T.; Yamano, A.; Kouguchi, H.; Takeshi, K.; Kamaguchi, A.; Fujinaga, Y.; Oguma, K.; Ohyama, T.
Characterization of toxin complex produced by a unique strain of Clostridium botulinum serotype D 4947
Protein J.
23
371-378
2004
Clostridium botulinum
Purcell, A.L.; Hoard-Fruchey, H.M.
A capillary electrophoresis method to assay catalytic activity of botulinum neurotoxin serotypes: implications for substrate specificity
Anal. Biochem.
366
207-217
2007
Clostridium botulinum
Kaiser, E.; Haug, G.; Hliscs, M.; Aktories, K.; Barth, H.
Formation of a biologically active toxin complex of the binary Clostridium botulinum C2 toxin without cell membrane interaction
Biochemistry
45
13361-13368
2006
Clostridium botulinum
Jin, R.; Sikorra, S.; Stegmann, C.M.; Pich, A.; Binz, T.; Brunger, A.T.
Structural and biochemical studies of botulinum neurotoxin serotype C1 light chain protease: implications for dual substrate specificity
Biochemistry
46
10685-10693
2007
Clostridium botulinum, Clostridium tetani
Silvaggi, N.R.; Wilson, D.; Tzipori, S.; Allen, K.N.
Catalytic features of the botulinum neurotoxin A light chain revealed by high resolution structure of an inhibitory peptide complex
Biochemistry
47
5736-5745
2008
Clostridium botulinum (P10845), Clostridium botulinum
Kukreja, R.V.; Sharma, S.; Cai, S.; Singh, B.R.
Role of two active site Glu residues in the molecular action of botulinum neurotoxin endopeptidase
Biochim. Biophys. Acta
1774
213-222
2007
Clostridium botulinum
Capkova, K.; Yoneda, Y.; Dickerson, T.J.; Janda, K.D.
Synthesis and structure-activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors
Bioorg. Med. Chem. Lett.
17
6463-6466
2007
Clostridium botulinum
Teymoortash, A.; Sommer, F.; Mandic, R.; Schulz, S.; Bette, M.; Aumueller, G.; Werner, J.A.
Intraglandular application of botulinum toxin leads to structural and functional changes in rat acinar cells
Br. J. Pharmacol.
152
161-167
2007
Clostridium botulinum
Silvaggi, N.R.; Boldt, G.E.; Hixon, M.S.; Kennedy, J.P.; Tzipori, S.; Janda, K.D.; Allen, K.N.
Structures of Clostridium botulinum neurotoxin serotype A light chain complexed with small-molecule inhibitors highlight active-site flexibility
Chem. Biol.
14
533-542
2007
Clostridium botulinum
Yerdelen, D.; Koc, F.; Sarica, Y.
Effects of botulinum toxin on strength-duration properties
Int. J. Neurosci.
117
1457-1464
2007
Clostridium botulinum
McAllister, L.A.; Hixon, M.S.; Kennedy, J.P.; Dickerson, T.J.; Janda, K.D.
Superactivation of the botulinum neurotoxin serotype A light chain metalloprotease: a new wrinkle in botulinum neurotoxin
J. Am. Chem. Soc.
128
4176-4177
2006
Clostridium botulinum
Chen, S.; Kim, J.J.; Barbieri, J.T.
Mechanism of substrate recognition by botulinum neurotoxin serotype A
J. Biol. Chem.
282
9621-9627
2007
Clostridium botulinum
Wang, J.; Meng, J.; Lawrence, G.W.; Zurawski, T.H.; Sasse, A.; Bodeker, M.O.; Gilmore, M.A.; Fernandez-Salas, E.; Francis, J.; Steward, L.E.; Aoki, K.R.; Dolly, J.O.
Novel chimeras of botulinum neurotoxin /A and /E unveil contributions from the binding, translocation and protease domains to their functional characteristics
J. Biol. Chem.
283
16993-17002
2008
Clostridium botulinum (Q00496)
Kumaran, D.; Rawat, R.; Ludivico, M.L.; Ahmed, S.A.; Swaminathan, S.
Structure and substrate based inhibitor design for clostridium botulinum neurotoxin serotype A
J. Biol. Chem.
283
18883-18891
2008
Clostridium botulinum (P10845), Clostridium botulinum
Neumeyer, T.; Schiffler, B.; Maier, E.; Lang, A.E.; Aktories, K.; Benz, R.
Clostridium botulinum C2 toxin. Identification of the binding site for chloroquine and related compounds and influence of the binding site on properties of the C2II channel
J. Biol. Chem.
283
3904-3914
2008
Clostridium botulinum
Sinha, J.; Inan, M.; Fanders, S.; Taoka, S.; Gouthro, M.; Swanson, T.; Barent, R.; Barthuli, A.; Loveless, B.M.; Smith, L.A.; Smith, T.; Henderson, I.; Ross, J.; Meagher, M.M.
Cell bank characterization and fermentation optimization for production of recombinant heavy chain C-terminal fragment of botulinum neurotoxin serotype E (rBoNTE(H(c)): antigen E) by Pichia pastoris
J. Biotechnol.
127
462-474
2007
Clostridium botulinum, Clostridium botulinum NCTC 11219
Burnett, J.C.; Opsenica, D.; Sriraghavan, K.; Panchal, R.G.; Ruthel, G.; Hermone, A.R.; Nguyen, T.L.; Kenny, T.A.; Lane, D.J.; McGrath, C.F.; Schmidt, J.J.; Vennerstrom, J.L.; Gussio, R.; Solaja, B.A.; Bavari, S.
A refined pharmacophore identifies potent 4-amino-7-chloroquinoline-based inhibitors of the botulinum neurotoxin serotype A metalloprotease
J. Med. Chem.
50
2127-2136
2007
Clostridium botulinum
Jin, R.; Rummel, A.; Binz, T.; Brunger, A.T.
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
Nature
444
1092-1095
2006
Clostridium botulinum
Tang, J.; Park, J.G.; Millard, C.B.; Schmidt, J.J.; Pang, Y.P.
Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A
PLoS ONE
2
e761
2007
Clostridium botulinum
Fang, H.; Luo, W.; Henkel, J.; Barbieri, J.; Green, N.
A yeast assay probes the interaction between botulinum neurotoxin serotype B and its SNARE substrate
Proc. Natl. Acad. Sci. USA
103
6958-6963
2006
Clostridium botulinum
Rawat, R.; Ashraf Ahmed, S.; Swaminathan, S.
High level expression of the light chain of botulinum neurotoxin serotype C1 and an efficient HPLC assay to monitor its proteolytic activity
Protein Expr. Purif.
60
165-169
2008
Clostridium botulinum
Suzuki, T.; Kouguchi, H.; Watanabe, T.; Hasegawa, K.; Yoneyama, T.; Niwa, K.; Nishikawa, A.; Lee, J.C.; Oguma, K.; Ohyama, T.
Effect of nicking the C-terminal region of the Clostridium botulinum serotype D neurotoxin heavy chain on its toxicity and molecular properties
Protein J.
26
173-181
2007
Clostridium botulinum
Ahmed, S.A.; Olson, M.A.; Ludivico, M.L.; Gilsdorf, J.; Smith, L.A.
Identification of residues surrounding the active site of type A botulinum neurotoxin important for substrate recognition and catalytic activity
Protein J.
27
151-162
2008
Clostridium botulinum
Antonucci, F.; Bozzi, Y.; Caleo, M.
Intrahippocampal infusion of botulinum neurotoxin E (BoNT/E) reduces spontaneous recurrent seizures in a mouse model of mesial temporal lobe epilepsy
Epilepsia
50
963-966
2009
Clostridium botulinum
Oeconomou, A.; Madersbacher, H.; Kiss, G.; Berger, T.J.; Melekos, M.; Rehder, P.
Is botulinum neurotoxin type A (BoNT-A) a novel therapy for lower urinary tract symptoms due to benign prostatic enlargement? A review of the literature
Eur. Urol.
54
765-775
2008
Clostridium botulinum
Antonucci, F.; Di Garbo, A.; Novelli, E.; Manno, I.; Sartucci, F.; Bozzi, Y.; Caleo, M.
Botulinum neurotoxin E (BoNT/E) reduces CA1 neuron loss and granule cell dispersion, with no effects on chronic seizures, in a mouse model of temporal lobe epilepsy
Exp. Neurol.
210
388-401
2008
Clostridium botulinum
Chen, S.; Hall, C.; Barbieri, J.T.
Substrate recognition of VAMP-2 by botulinum neurotoxin B and tetanus neurotoxin
J. Biol. Chem.
283
21153-21159
2008
Clostridium tetani
Uchida, H.; Matsumoto, M.; Ueda, H.
Profiling of BoNT/C3-reversible gene expression induced by lysophosphatidic acid: ephrinB1 gene up-regulation underlying neuropathic hyperalgesia and allodynia
Neurochem. Int.
54
215-221
2009
Clostridium botulinum, Clostridium botulinum C3
Nuemket, N.; Tanaka, Y.; Tsukamoto, K.; Tsuji, T.; Nakamura, K.; Kozaki, S.; Yao, M.; Tanaka, I.
Preliminary X-ray crystallographic study of the receptor-binding domain of the D/C mosaic neurotoxin from Clostridium botulinum
Acta Crystallogr. Sect. F
66
608-610
2010
Clostridium botulinum (A5JGM8), Clostridium botulinum
Tsai, C.Y.; Chiu, W.C.; Liao, Y.H.; Tsai, C.M.
Effects on craniofacial growth and development of unilateral botulinum neurotoxin injection into the masseter muscle
Am. J. Orthod. Dentofacial. Orthop.
135
142.e1-6
2009
Clostridium botulinum
Rowe, B.; Schmidt, J.J.; Smith, L.A.; Ahmed, S.A.
Rapid product analysis and increased sensitivity for quantitative determinations of botulinum neurotoxin proteolytic activity
Anal. Biochem.
396
188-193
2010
Clostridium botulinum
Ozanich, R.M.; Bruckner-Lea, C.J.; Warner, M.G.; Miller, K.; Antolick, K.C.; Marks, J.D.; Lou, J.; Grate, J.W.
Rapid multiplexed flow cytometric assay for botulinum neurotoxin detection using an automated fluidic microbead-trapping flow cell for enhanced sensitivity
Anal. Chem.
81
5783-5793
2009
Clostridium botulinum
Montal, M.
Botulinum neurotoxin: a marvel of protein design
Annu. Rev. Biochem.
79
591-617
2010
Clostridium botulinum
Roxas-Duncan, V.; Enyedy, I.; Montgomery, V.A.; Eccard, V.S.; Carrington, M.A.; Lai, H.; Gul, N.; Yang, D.C.; Smith, L.A.
Identification and biochemical characterization of small-molecule inhibitors of Clostridium botulinum neurotoxin serotype A
Antimicrob. Agents Chemother.
53
3478-3486
2009
Clostridium botulinum
Poras, H.; Ouimet, T.; Orng, S.V.; Fournie-Zaluski, M.C.; Popoff, M.R.; Roques, B.P.
Detection and quantification of botulinum neurotoxin type A by a novel rapid in vitro fluorimetric assay
Appl. Environ. Microbiol.
75
4382-4390
2009
Clostridium botulinum
De Medici, D.; Anniballi, F.; Wyatt, G.M.; Lindstroem, M.; Messelhaeusser, U.; Aldus, C.F.; Delibato, E.; Korkeala, H.; Peck, M.W.; Fenicia, L.
Multiplex PCR for detection of botulinum neurotoxin-producing clostridia in clinical, food, and environmental samples
Appl. Environ. Microbiol.
75
6457-6461
2009
Clostridium botulinum (A2I2R9), Clostridium botulinum (Q58GH1), Clostridium botulinum
Lin, G.; Tepp, W.H.; Pier, C.L.; Jacobson, M.J.; Johnson, E.A.
Expression of the Clostridium botulinum A2 neurotoxin gene cluster proteins and characterization of the A2 complex
Appl. Environ. Microbiol.
76
40-47
2010
Clostridium botulinum
Raphael, B.H.; Choudoir, M.J.; Luquez, C.; Fernandez, R.; Maslanka, S.E.
Sequence diversity of genes encoding botulinum neurotoxin type F
Appl. Environ. Microbiol.
76
4805-4812
2010
Clostridium botulinum (C5IWN7), Clostridium botulinum (D2KCK3), Clostridium botulinum (P30996), Clostridium botulinum (Q58GH1), Clostridium botulinum, Clostridium baratii (Q45851), Clostridium baratii
Muraro, L.; Tosatto, S.; Motterlini, L.; Rossetto, O.; Montecucco, C.
The N-terminal half of the receptor domain of botulinum neurotoxin A binds to microdomains of the plasma membrane
Biochem. Biophys. Res. Commun.
380
76-80
2009
Clostridium botulinum
Chang, T.W.; Blank, M.; Janardhanan, P.; Singh, B.R.; Mello, C.; Blind, M.; Cai, S.
In vitro selection of RNA aptamers that inhibit the activity of type A botulinum neurotoxin
Biochem. Biophys. Res. Commun.
396
854-860
2010
Clostridium botulinum
Henkel, J.S.; Jacobson, M.; Tepp, W.; Pier, C.; Johnson, E.A.; Barbieri, J.T.
Catalytic properties of botulinum neurotoxin subtypes A3 and A4
Biochemistry
48
2522-2528
2009
Clostridium botulinum
Fu, Z.; Chen, C.; Barbieri, J.T.; Kim, J.J.; Baldwin, M.R.
Glycosylated SV2 and gangliosides as dual receptors for botulinum neurotoxin serotype F
Biochemistry
48
5631-5641
2009
Clostridium botulinum (Q57236)
Kukreja, R.V.; Sharma, S.K.; Singh, B.R.
Molecular basis of activation of endopeptidase activity of botulinum neurotoxin type E
Biochemistry
49
2510-2519
2010
Clostridium botulinum
Schmitt, J.; Karalewitz, A.; Benefield, D.A.; Mushrush, D.J.; Pruitt, R.N.; Spiller, B.W.; Barbieri, J.T.; Lacy, D.B.
Structural analysis of botulinum neurotoxin type G receptor binding
Biochemistry
49
5200-5205
2010
Clostridium botulinum (Q60393)
Moghaddam, M.M.; Mousavi, L.; Shokrgozar, M.A.; Amani, J.; Nazariyan, S.; Azari, S.
Cloning and expression of a region of vesicle associated membrane protein2 (VAMP2) gene and its use as a recombinant peptide substrate for assaying clostridial neurotoxins in contaminated biologicals
Biologicals
38
113-119
2010
Clostridium botulinum
Mansour, A.A.; Mousavi, S.L.; Rasooli, I.; Nazarian, S.; Amani, J.; Farhadi, N.
Cloning, high level expression and immunogenicity of 1163-1256 residues of C-terminal heavy chain of C. botulinum neurotoxin type E
Biologicals
38
260-264
2010
Clostridium botulinum
Salzameda, N.T.; Barbieri, J.T.; Janda, K.D.
Synthetic substrate for application in both high and low throughput assays for botulinum neurotoxin B protease inhibitors
Bioorg. Med. Chem. Lett.
19
5848-5850
2009
Clostridium botulinum
Warner, M.G.; Grate, J.W.; Tyler, A.; Ozanich, R.M.; Miller, K.D.; Lou, J.; Marks, J.D.; Bruckner-Lea, C.J.
Quantum dot immunoassays in renewable surface column and 96-well plate formats for the fluorescence detection of botulinum neurotoxin using high-affinity antibodies
Biosens. Bioelectron.
25
179-184
2009
Clostridium botulinum
Pannek, J.; Goecking, K.; Bersch, U.
Long-term effects of repeated intradetrusor botulinum neurotoxin A injections on detrusor function in patients with neurogenic bladder dysfunction
BJU Int.
104
1246-1250
2009
Clostridium botulinum
Hill, K.K.; Xie, G.; Foley, B.T.; Smith, T.J.; Munk, A.C.; Bruce, D.; Smith, L.A.; Brettin, T.S.; Detter, J.C.
Recombination and insertion events involving the botulinum neurotoxin complex genes in Clostridium botulinum types A, B, E and F and Clostridium butyricum type E strains
BMC Biol.
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66
2009
Clostridium botulinum, Clostridium butyricum
Scotcher, M.C.; Johnson, E.A.; Stanker, L.H.
Characterization of the epitope region of F1-2 and F1-5, two monoclonal antibodies to botulinum neurotoxin type A
Hybridoma
28
315-325
2009
Clostridium botulinum, Clostridium botulinum ATCC 3502
Shone, C.; Agostini, H.; Clancy, J.; Gu, M.; Yang, H.H.; Chu, Y.; Johnson, V.; Taal, M.; McGlashan, J.; Brehm, J.; Tong, X.
Bivalent recombinant vaccine for botulinum neurotoxin types A and B based on a polypeptide comprising their effector and translocation domains that is protective against the predominant A and B subtypes
Infect. Immun.
77
2795-2801
2009
Clostridium botulinum (P10844), Clostridium botulinum (P10845)
Cheng, L.W.; Stanker, L.H.; Henderson, T.D.; Lou, J.; Marks, J.D.
Antibody protection against botulinum neurotoxin intoxication in mice
Infect. Immun.
77
4305-4313
2009
Clostridium botulinum
Fach, P.; Fenicia, L.; Knutsson, R.; Wielinga, P.R.; Anniballi, F.; Delibato, E.; Auricchio, B.; Woudstra, C.; Agren, J.; Segerman, B.; de Medici, D.; van Rotterdam, B.J.
An innovative molecular detection tool for tracking and tracing Clostridium botulinum types A, B, E, F and other botulinum neurotoxin producing Clostridia based on the GeneDisc cycler
Int. J. Food Microbiol.
145
S145-151
2011
Clostridium baratii, Clostridium botulinum, Clostridium butyricum
Silhar, P.; Capkova, K.; Salzameda, N.T.; Barbieri, J.T.; Hixon, M.S.; Janda, K.D.
Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors
J. Am. Chem. Soc.
132
2868-2869
2010
Clostridium botulinum
Evans, E.R.; Skipper, P.J.; Shone, C.C.
An assay for botulinum toxin types A, B and F that requires both functional binding and catalytic activities within the neurotoxin
J. Appl. Microbiol.
107
1384-1391
2009
Clostridium botulinum
Thanongsaksrikul, J.; Srimanote, P.; Maneewatch, S.; Choowongkomon, K.; Tapchaisri, P.; Makino, S.; Kurazono, H.; Chaicumpa, W.
A V H H that neutralizes the zinc metalloproteinase activity of botulinum neurotoxin type A
J. Biol. Chem.
285
9657-9666
2010
Clostridium botulinum (P10845)
Nuss, J.E.; Ruthel, G.; Tressler, L.E.; Wanner, L.M.; Torres-Melendez, E.; Hale, M.L.; Bavari, S.
Development of cell-based assays to measure botulinum neurotoxin serotype A activity using cleavage-sensitive antibodies
J. Biomol. Screen.
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42-51
2010
Clostridium botulinum
Shi, X.; Garcia, G.E.; Neill, R.J.; Gordon, R.K.
TCEP treatment reduces proteolytic activity of BoNT/B in human neuronal SHSY-5Y cells
J. Cell. Biochem.
107
1021-1030
2009
Clostridium botulinum
Shi, X.; Curran, J.E.; Liao, Z.; Gordon, R.K.
The biological activity of ubiquitinated BoNT/B light chain in vitro and in human SHSY-5Y neuronal cells
J. Cell. Biochem.
108
660-667
2009
Clostridium botulinum
Li, B.; Pai, R.; Cardinale, S.C.; Butler, M.M.; Peet, N.P.; Moir, D.T.; Bavari, S.; Bowlin, T.L.
Synthesis and biological evaluation of botulinum neurotoxin A protease inhibitors
J. Med. Chem.
53
2264-2276
2010
Clostridium botulinum
Kumaran, D.; Eswaramoorthy, S.; Furey, W.; Navaza, J.; Sax, M.; Swaminathan, S.
Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation
J. Mol. Biol.
386
233-245
2009
Clostridium botulinum (Q00496), Clostridium botulinum
Dong, J.; Thompson, A.A.; Fan, Y.; Lou, J.; Conrad, F.; Ho, M.; Pires-Alves, M.; Wilson, B.A.; Stevens, R.C.; Marks, J.D.
A single-domain llama antibody potently inhibits the enzymatic activity of botulinum neurotoxin by binding to the non-catalytic alpha-exosite binding region
J. Mol. Biol.
397
1106-1118
2010
Clostridium botulinum
Caleo, M.; Antonucci, F.; Restani, L.; Mazzocchio, R.
A reappraisal of the central effects of botulinum neurotoxin type A: by what mechanism?
J. Neurochem.
109
15-24
2009
Clostridium botulinum
Rummel, A.; Haefner, K.; Mahrhold, S.; Darashchonak, N.; Holt, M.; Jahn, R.; Beermann, S.; Karnath, T.; Bigalke, H.; Binz, T.
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor
J. Neurochem.
110
1942-1954
2009
Clostridium botulinum
Coffield, J.A.; Yan, X.
Neuritogenic actions of botulinum neurotoxin A on cultured motor neurons
J. Pharmacol. Exp. Ther.
330
352-358
2009
Clostridium botulinum
Thyagarajan, B.; Krivitskaya, N.; Potian, J.G.; Hognason, K.; Garcia, C.C.; McArdle, J.J.
Capsaicin protects mouse neuromuscular junctions from the neuroparalytic effects of botulinum neurotoxin A
J. Pharmacol. Exp. Ther.
331
361-371
2009
Clostridium botulinum
Pellett, S.; Tepp, W.H.; Toth, S.I.; Johnson, E.A.
Comparison of the primary rat spinal cord cell (RSC) assay and the mouse bioassay for botulinum neurotoxin type A potency determination
J. Pharmacol. Toxicol. Methods
61
304-310
2010
Clostridium botulinum
Sun, S.; Ossandon, M.; Kostov, Y.; Rasooly, A.
Lab-on-a-chip for botulinum neurotoxin a (BoNT-A) activity analysis
Lab Chip
9
3275-3281
2009
Clostridium botulinum
Shi, J.; Li, T.; Hou, X.; Cai, K.; Bao, S.; Liu, H.; Gao, X.; Xiao, L.; Tu, W.; Wang, Q.; Yin, J.; Wang, H.
Recombinant luminal domain of human synaptotagmin II in combination with gangliosides inhibits the toxicity of botulinum neurotoxins in mice
Microbes Infect.
12
319-323
2010
Clostridium botulinum
Agarwal, R.; Schmidt, J.J.; Stafford, R.G.; Swaminathan, S.
Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F
Nat. Struct. Mol. Biol.
16
789-794
2009
Clostridium botulinum (P30996), Clostridium botulinum
Antonucci, F.; Cerri, C.; Vetencourt, J.F.; Caleo, M.
Acute neuroprotection by the synaptic blocker botulinum neurotoxin E in a rat model of focal cerebral ischaemia
Neuroscience
169
395-401
2010
Clostridium botulinum
Stowe, G.N.; Silhar, P.; Hixon, M.S.; Silvaggi, N.R.; Allen, K.N.; Moe, S.T.; Jacobson, A.R.; Barbieri, J.T.; Janda, K.D.
Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype A protease
Org. Lett.
12
756-759
2010
Clostridium botulinum
Miller, D.; Richardson, D.; Eisa, M.; Bajwa, R.J.; Jabbari, B.
Botulinum neurotoxin-A for treatment of refractory neck pain: a randomized, double-blind study
Pain Med.
10
1012-1017
2009
Clostridium botulinum
Carmichael, N.M.; Dostrovsky, J.O.; Charlton, M.P.
Peptide-mediated transdermal delivery of botulinum neurotoxin type A reduces neurogenic inflammation in the skin
Pain
149
316-324
2010
Clostridium botulinum
Franciosa, G.; Maugliani, A.; Scalfaro, C.; Aureli, P.
Evidence that plasmid-borne botulinum neurotoxin type B genes are widespread among Clostridium botulinum serotype B strains
PLoS ONE
4
e4829
2009
Clostridium botulinum (A2I2U3), Clostridium botulinum (A2I2W1), Clostridium botulinum (Q08077), Clostridium botulinum (Q93G71), Clostridium botulinum
Scotcher, M.C.; McGarvey, J.A.; Johnson, E.A.; Stanker, L.H.
Epitope characterization and variable region sequence of f1-40, a high-affinity monoclonal antibody to botulinum neurotoxin type a (Hall strain)
PLoS ONE
4
e4924
2009
Clostridium botulinum
Kalb, S.R.; Lou, J.; Garcia-Rodriguez, C.; Geren, I.N.; Smith, T.J.; Moura, H.; Marks, J.D.; Smith, L.A.; Pirkle, J.L.; Barr, J.R.
Extraction and inhibition of enzymatic activity of botulinum neurotoxins/A1, /A2, and /A3 by a panel of monoclonal anti-BoNT/A antibodies
PLoS ONE
4
e5355
2009
Clostridium botulinum
Pang, Y.P.; Davis, J.; Wang, S.; Park, J.G.; Nambiar, M.P.; Schmidt, J.J.; Millard, C.B.
Small molecules showing significant protection of mice against botulinum neurotoxin serotype A
PLoS ONE
5
e10129
2010
Clostridium botulinum
Conway, J.O.; Sherwood, L.J.; Collazo, M.T.; Garza, J.A.; Hayhurst, A.
Llama single domain antibodies specific for the 7 botulinum neurotoxin serotypes as heptaplex immunoreagents
PLoS ONE
5
e8818
2010
Clostridium botulinum
Fischer, A.; Nakai, Y.; Eubanks, L.M.; Clancy, C.M.; Tepp, W.H.; Pellett, S.; Dickerson, T.J.; Johnson, E.A.; Janda, K.D.; Montal, M.
Bimodal modulation of the botulinum neurotoxin protein-conducting channel
Proc. Natl. Acad. Sci. USA
106
1330-1335
2009
Clostridium botulinum
Chen, S.; Barbieri, J.T.
Engineering botulinum neurotoxin to extend therapeutic intervention
Proc. Natl. Acad. Sci. USA
106
9180-9184
2009
Clostridium botulinum
Band, P.A.; Blais, S.; Neubert, T.A.; Cardozo, T.J.; Ichtchenko, K.
Recombinant derivatives of botulinum neurotoxin A engineered for trafficking studies and neuronal delivery
Protein Expr. Purif.
71
62-73
2010
Clostridium botulinum
Chen, R.; Shi, J.; Cai, K.; Tu, W.; Hou, X.; Liu, H.; Xiao, L.; Wang, Q.; Tang, Y.; Wang, H.
Improved soluble expression and characterization of the Hc domain of Clostridium botulinum neurotoxin serotype A in Escherichia coli by using a PCR-synthesized gene and a Trx co-expression strain
Protein Expr. Purif.
71
79-84
2010
Clostridium botulinum (P10845), Clostridium botulinum
Pires-Alves, M.; Ho, M.; Aberle, K.K.; Janda, K.D.; Wilson, B.A.
Tandem fluorescent proteins as enhanced FRET-based substrates for botulinum neurotoxin activity
Toxicon
53
392-399
2009
Clostridium botulinum
Kukreja, R.; Chang, T.W.; Cai, S.; Lindo, P.; Riding, S.; Zhou, Y.; Ravichandran, E.; Singh, B.R.
Immunological characterization of the subunits of type A botulinum neurotoxin and different components of its associated proteins
Toxicon
53
616-624
2009
Clostridium botulinum, Clostridium botulinum ATCC 3502
Baldwin, M.R.; Barbieri, J.T.
Association of botulinum neurotoxins with synaptic vesicle protein complexes
Toxicon
54
570-574
2009
Clostridium botulinum
Atassi, M.Z.
Immune recognition of BoNTs A and B: how anti-toxin antibodies that bind to the heavy chain obstruct toxin action
Toxicon
54
600-613
2009
Clostridium botulinum
Hakami, R.M.; Ruthel, G.; Stahl, A.M.; Bavari, S.
Gaining ground: assays for therapeutics against botulinum neurotoxin
Trends Microbiol.
18
164-172
2010
Clostridium baratii, Clostridium botulinum, Clostridium butyricum
Amend, B.; Castro-Diaz, D.; Chartier-Kastler, E.; De Ridder, D.; Everaert, K.; Spinelli, M.; van Keerebroeck, P.; Sievert, K.D.
[Second-line-Therapie der idiopathisch beraktiven Blase. Sakrale Neuromodulation und Botulinumtoxin A]
Urologe
49
245-252
2010
Clostridium botulinum
Webb, R.P.; Smith, T.J.; Wright, P.; Brown, J.; Smith, L.A.
Production of catalytically inactive BoNT/A1 holoprotein and comparison with BoNT/A1 subunit vaccines against toxin subtypes A1, A2, and A3
Vaccine
27
4490-4497
2009
Clostridium botulinum
Niwa, K.; Yoneyama, T.; Ito, H.; Taira, M.; Chikai, T.; Kouguchi, H.; Suzuki, T.; Hasegawa, K.; Miyata, K.; Inui, K.; Ikeda, T.; Watanabe, T.; Ohyama, T.
Sialic acid-dependent binding and transcytosis of serotype D botulinum neurotoxin and toxin complex in rat intestinal epithelial cells
Vet. Microbiol.
141
312-320
2010
Clostridium botulinum
Wang, H.H.; Riding, S.; Lindo, P.; Singh, B.R.
Endopeptidase activities of botulinum neurotoxin type B complex, holotoxin, and light chain
Appl. Environ. Microbiol.
76
6658-6663
2010
Clostridium botulinum
Kalb, S.R.; Baudys, J.; Egan, C.; Smith, T.J.; Smith, L.A.; Pirkle, J.L.; Barr, J.R.
Different substrate recognition requirements for cleavage of synaptobrevin-2 by Clostridium baratii and Clostridium botulinum type F neurotoxins
Appl. Environ. Microbiol.
77
1301-1308
2011
Clostridium baratii, Clostridium botulinum
Jacobson, M.J.; Lin, G.; Tepp, W.; Dupuy, J.; Stenmark, P.; Stevens, R.C.; Johnson, E.A.
Purification, modeling, and analysis of botulinum neurotoxin subtype A5 (BoNT/A5) from Clostridium botulinum strain A661222
Appl. Environ. Microbiol.
77
4217-4222
2011
Clostridium botulinum (C7BEA8), Clostridium botulinum
Zhang, Y.; Buchko, G.W.; Qin, L.; Robinson, H.; Varnum, S.M.
Crystal structure of the receptor binding domain of the botulinum C-D mosaic neurotoxin reveals potential roles of lysines 1118 and 1136 in membrane interactions
Biochem. Biophys. Res. Commun.
404
407-412
2011
Clostridium botulinum (Q5DW55), Clostridium botulinum
Pellett, S.; Tepp, W.H.; Stanker, L.H.; Band, P.A.; Johnson, E.A.; Ichtchenko, K.
Neuronal targeting, internalization, and biological activity of a recombinant atoxic derivative of botulinum neurotoxin A
Biochem. Biophys. Res. Commun.
405
673-677
2011
Clostridium botulinum
Chen, S.; Wan, H.Y.
Molecular mechanisms of substrate recognition and specificity of botulinum neurotoxin serotype F
Biochem. J.
433
277-284
2011
Clostridium botulinum
Capkova, K.; Hixon, M.; Pellett, S.; Barbieri, J.; Johnson, E.; Janda, K.
Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin As zinc endopeptidase
Bioorg. Med. Chem. Lett.
20
206-208
2010
Clostridium botulinum
Li, B.; Cardinale, S.C.; Butler, M.M.; Pai, R.; Nuss, J.E.; Peet, N.P.; Bavari, S.; Bowlin, T.L.
Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors
Bioorg. Med. Chem.
19
7338-7348
2011
Clostridium botulinum
Kumar, G.; Agarwal, R.; Swaminathan, S.
Discovery of a fluorene class of compounds as inhibitors of botulinum neurotoxin serotype E by virtual screening
Chem. Commun. (Camb. )
48
2412-2414
2012
Clostridium botulinum
Hale, M.; Oyler, G.; Swaminathan, S.; Ahmed, S.A.
Basic tetrapeptides as potent intracellular inhibitors of type A botulinum neurotoxin protease activity
J. Biol. Chem.
286
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Clostridium botulinum
Benson, M.A.; Fu, Z.; Kim, J.J.; Baldwin, M.R.
Unique ganglioside recognition strategies for clostridial neurotoxins
J. Biol. Chem.
286
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2011
Clostridium botulinum (Q57236)
Gul, N.; Smith, L.; Ahmed, S.
Light chain separated from the rest of the type a botulinum neurotoxin molecule is the most catalytically active form
PLoS ONE
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e12872
2010
Clostridium botulinum
Atassi, M.Z.; Dolimbek, B.Z.; Steward, L.E.; Aoki, K.R.
Inhibition of botulinum neurotoxin a toxic action in vivo by synthetic synaptosome- and blocking antibody-binding regions
Protein J.
29
320-327
2010
Clostridium botulinum
Bagramyan, K.; Kaplan, B.; Cheng, L.; Strotmeier, J.; Rummel, A.; Kalkum, M.
Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples
Anal. Chem.
85
5569-5576
2013
Clostridium botulinum
Tepp, W.; Lin, G.; Johnson, E.
Purification and characterization of a novel subtype A3 botulinum neurotoxin
Appl. Environ. Microbiol.
78
3108-3113
2012
Clostridium botulinum (B1L2G4), Clostridium botulinum, Clostridium botulinum A3 (B1L2G4)
Dunning, F.; Ruge, D.; Piazza, T.; Stanker, L.; Zeytin, F.; Tucker, W.
Detection of botulinum neurotoxin serotype A, B, and F proteolytic activity in complex matrices with picomolar to femtomolar sensitivity
Appl. Environ. Microbiol.
78
7687-7697
2012
Clostridium botulinum
Bradshaw, M.; Tepp, W.; Whitemarsh, R.; Pellett, S.; Johnson, E.
Holotoxin activity of botulinum neurotoxin subtype A4 originating from a nontoxigenic Clostridium botulinum expression system
Appl. Environ. Microbiol.
80
7415-7422
2014
Clostridium botulinum, Clostridium botulinum 657Ba
Inui, K.; Sagane, Y.; Miyata, K.; Miyashita, S.; Suzuki, T.; Shikamori, Y.; Ohyama, T.; Niwa, K.; Watanabe, T.
Toxic and nontoxic components of botulinum neurotoxin complex are evolved from a common ancestral zinc protein
Biochem. Biophys. Res. Commun.
419
500-504
2012
Clostridium botulinum (A5HZZ9), Clostridium botulinum (A7GBG3), Clostridium botulinum (B1INP5), Clostridium botulinum (P18640)
Lee, K.; Lam, K.; Kruel, A.; Perry, K.; Rummel, A.; Jin, R.
High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex
Biochem. Biophys. Res. Commun.
446
568-573
2014
Clostridium botulinum, Clostridium botulinum Okra
Itakura, M.; Kohda, T.; Kubo, T.; Semi, Y.; Azuma, Y.; Nakajima, H.; Kozaki, S.; Takeuchi, T.
Botulinum neurotoxin A subtype 2 reduces pathological behaviors more effectively than subtype 1 in a rat Parkinsons disease model
Biochem. Biophys. Res. Commun.
447
311-314
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Clostridium botulinum (P10845), Clostridium botulinum (Q58GH1), Clostridium botulinum Chiba-H (Q58GH1), Clostridium botulinum 62A (P10845)
Sun, S.; Tepp, W.; Johnson, E.; Chapman, E.
Botulinum neurotoxins B and E translocate at different rates and exhibit divergent responses to GT1b and low pH
Biochemistry
51
5655-5662
2012
Clostridium botulinum (P10844), Clostridium botulinum (Q00496)
Wang, D.; Krilich, J.; Pellett, S.; Baudys, J.; Tepp, W.; Barr, J.; Johnson, E.; Kalb, S.
Comparison of the catalytic properties of the botulinum neurotoxin subtypes A1 and A5
Biochim. Biophys. Acta
1834
2722-2728
2013
Clostridium botulinum (C7BEA8), Clostridium botulinum (Q7B8V4), Clostridium botulinum, Clostridium botulinum Hall A hyper (Q7B8V4), Clostridium botulinum A661222 (C7BEA8)
Kumar, R.; Kukreja, R.; Cai, S.; Singh, B.
Differential role of molten globule and protein folding in distinguishing unique features of botulinum neurotoxin
Biochim. Biophys. Acta
1844
1145-1152
2014
Clostridium botulinum (P10844), Clostridium botulinum (Q00496), Clostridium botulinum (Q7B8V4)
Chellappan, G.; Kumar, R.; Santos, E.; Goyal, D.; Cai, S.; Singh, B.
Structural and functional analysis of botulinum neurotoxin subunits for pH-dependent membrane channel formation and translocation
Biochim. Biophys. Acta
1854
1510-1516
2015
Clostridium botulinum (Q7B8V4), Clostridium botulinum Hall (Q7B8V4)
Kumar, R.; Cai, S.; Ojadi, E.; Singh, B.
Resolution of sub-nanosecond motions in botulinum neurotoxin endopeptidase: An evidence of internal flexibility
Biochim. Biophys. Acta
1854
321-326
2015
Clostridium botulinum (Q7B8V4)
Zhang, Y.; Gardberg, A.; Edwards, T.; Sankaran, B.; Robinson, H.; Varnum, S.; Buchko, G.
Structural insights into the functional role of the Hcn sub-domain of the receptor-binding domain of the botulinum neurotoxin mosaic serotype C/D
Biochimie
95
1379-1385
2013
Clostridium botulinum (Q5DW55), Clostridium botulinum
Seki, H.; Pellett, S.; Silhar, P.; Stowe, G.; Blanco, B.; Lardy, M.; Johnson, E.; Janda, K.
Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for botulinum neurotoxin A light chain
Bioorg. Med. Chem.
22
1208-1217
2014
Clostridium botulinum (A5HZZ9), Clostridium botulinum Hall (A5HZZ9)
Bremer, P.; Hixon, M.; Janda, K.
Benzoquinones as inhibitors of botulinum neurotoxin serotype A
Bioorg. Med. Chem.
22
3971-3981
2014
Clostridium botulinum (A5HZZ9)
Seki, H.; Xue, S.; Hixon, M.; Pellett, S.; Reme, M.; Johnson, E.; Janda, K.
Toward the discovery of dual inhibitors for botulinum neurotoxin A: Concomitant targeting of endocytosis and light chain protease activity
Chem. Commun. (Camb. )
51
6226-6229
2015
Clostridium botulinum (A5HZZ9)
Pirazzini, M.; Henke, T.; Rossetto, O.; Mahrhold, S.; Krez, N.; Rummel, A.; Montecucco, C.; Binz, T.
Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain
FEBS Lett.
587
3831-3836
2013
Clostridium botulinum (P10844), Clostridium botulinum Okra (P10844)
Vijayalakshmi Ayyar, B.; Roger Aoki, K.; Zouhair Atassi, M.
The C-terminal heavy-chain domain of botulinum neurotoxin A is not the only site that binds neurons, as the N-terminal heavy-chain domain also plays a very active role in toxin-cell binding and interactions
Infect. Immun.
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1465-1476
2015
Clostridium botulinum, Clostridium botulinum Okra
Mizanur, R.; Frasca, V.; Swaminathan, S.; Bavari, S.; Webb, R.; Smith, L.; Ahmed, S.
The C terminus of the catalytic domain of type A botulinum neurotoxin may facilitate product release from the active site
J. Biol. Chem.
288
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Clostridium botulinum
Guo, J.; Chen, S.
Unique substrate recognition mechanism of the botulinum neurotoxin D light chain
J. Biol. Chem.
288
27881-27887
2013
Clostridium botulinum (P19321)
Kumar, R.; Kukreja, R.; Li, L.; Zhmurov, A.; Kononova, O.; Cai, S.; Ahmed, S.; Barsegov, V.; Singh, B.
Botulinum neurotoxin: Unique folding of enzyme domain of the most-poisonous poison
J. Biomol. Struct. Dyn.
32
804-815
2014
Clostridium botulinum (P10845)
Dadgar, S.; Ramjan, Z.; Floriano, W.
Paclitaxel is an inhibitor and its boron dipyrromethene derivative is a fluorescent recognition agent for botulinum neurotoxin subtype A
J. Med. Chem.
56
2791-2803
2013
Clostridium botulinum (P10845)
Opsenica, I.; Tot, M.; Gomba, L.; Nuss, J.; Sciotti, R.; Bavari, S.; Burnett, J.; Solaja, B.
4-amino-7-chloroquinolines: Probing ligand efficiency provides botulinum neurotoxin serotype a light chain inhibitors with significant antiprotozoal activity
J. Med. Chem.
56
5860-5871
2013
Clostridium botulinum (P10845)
Matsui, T.; Gu, S.; Lam, K.; Carter, L.; Rummel, A.; Mathews, I.; Jin, R.
Structural basis of the pH-dependent assembly of a botulinum neurotoxin complex
J. Mol. Biol.
426
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2014
Clostridium botulinum (P10845)
Berntsson, R.; Peng, L.; Dong, M.; Stenmark, P.
Structure of dual receptor binding to botulinum neurotoxin B
Nat. Commun.
4
2058
2013
Clostridium botulinum (Q33CP3)
Benoit, R.; Frey, D.; Hilbert, M.; Kevenaar, J.; Wieser, M.; Stirnimann, C.; McMillan, D.; Ceska, T.; Lebon, F.; Jaussi, R.; Steinmetz, M.; Schertler, G.; Hoogenraad, C.; Capitani, G.; Kammerer, R.
Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A
Nature
505
108-111
2014
Clostridium botulinum (P10845)
Ben David, A.; Torgeman, A.; Barnea, A.; Zichel, R.
Expression, purification and characterization of the receptor-binding domain of botulinum neurotoxin serotype B as a vaccine candidate
Protein Expr. Purif.
110
122-129
2015
Clostridium botulinum (P10844), Clostridium botulinum B (P10844)
Guo, J.; Chen, S.
Expression and biochemical characterization of light chains of Botulinum neurotoxin subtypes F5 and F7
Protein Expr. Purif.
111
87-90
2015
Clostridium botulinum, Clostridium botulinum (D2KHS9)
Singh, A.; Sachdeva, A.; Degrasse, J.; Croley, T.; Stanker, L.; Hodge, D.; Sharma, S.
Purification and characterization of neurotoxin complex from a dual toxin gene containing Clostridium botulinum strain PS-5
Protein J.
32
288-296
2013
Clostridium botulinum (P10844), Clostridium botulinum (P10845), Clostridium botulinum PS-5 (P10844), Clostridium botulinum PS-5 (P10845)
Guo, J.; Wang, J.; Chan, E.; Chen, S.
Exploration of endogenous substrate cleavage by various forms of botulinum neurotoxins
Toxicon
100
42-45
2015
Clostridium botulinum
Pellett, S.; Tepp, W.; Scherf, J.; Pier, C.; Johnson, E.
Activity of botulinum neurotoxin type D (strain 1873) in human neurons
Toxicon
101
63-69
2015
Clostridium botulinum, Clostridium botulinum 1873
Montgomery, V.; Ahmed, S.; Olson, M.; Mizanur, R.; Stafford, R.; Roxas-Duncan, V.; Smith, L.
Ex vivo inhibition of Clostridium botulinum neurotoxin types B, C, E, and F by small molecular weight inhibitors
Toxicon
98
12-19
2015
Clostridium botulinum
Kalb, S.R.; Baudys, J.; Raphael, B.H.; Dykes, J.K.; Luquez, C.; Maslanka, S.E.; Barr, J.R.
Functional characterization of botulinum neurotoxin serotype H as a hybrid of known serotypes F and A (BoNT F/A)
Anal. Chem.
87
3911-3917
2015
Clostridium botulinum, Clostridium botulinum IBCA10-7060
Minnow, Y.V.; Goldberg, R.; Tummalapalli, S.R.; Rotella, D.P.; Goodey, N.M.
Mechanism of inhibition of botulinum neurotoxin type A light chain by two quinolinol compounds
Arch. Biochem. Biophys.
618
15-22
2017
Clostridium botulinum
Kumar, G.; Agarwal, R.; Swaminathan, S.
Small molecule non-peptide inhibitors of botulinum neurotoxin serotype E Structure-activity relationship and a pharmacophore model
Bioorg. Med. Chem.
24
3978-3985
2016
Clostridium botulinum
Harrell, W.A.; Vieira, R.C.; Ensel, S.M.; Montgomery, V.; Guernieri, R.; Eccard, V.S.; Campbell, Y.; Roxas-Duncan, V.; Cardellina, J.H.; Webb, R.P.; Smith, L.A.
A matrix-focused structure-activity and binding site flexibility study of quinolinol inhibitors of botulinum neurotoxin serotype A
Bioorg. Med. Chem. Lett.
27
675-678
2017
Clostridium botulinum
Kerscher, M.; Wanitphakdeedecha, R.; Trindade de Almeida, A.; Maas, C.; Frevert, J.
IncobotulinumtoxinA A highly purified and precisely manufactured botulinum neurotoxin type A
J. Drugs Dermatol.
18
52-57
2019
Clostridium botulinum, Clostridium botulinum Hall
Sikorra, S.; Litschko, C.; Mueller, C.; Thiel, N.; Galli, T.; Eichner, T.; Binz, T.
Identification and characterization of botulinum neurotoxin A substrate binding pockets and their re-engineering for human SNAP-23
J. Mol. Biol.
428
372-384
2016
Clostridium botulinum
Davies, J.R.; Rees, J.; Liu, S.M.; Acharya, K.R.
High resolution crystal structures of Clostridium botulinum neurotoxin A3 and A4 binding domains
J. Struct. Biol.
202
113-117
2018
Clostridium botulinum (Q3LRX8), Clostridium botulinum (Q3LRX9), Clostridium botulinum
Kohda, T.; Nakamura, K.; Hosomi, K.; Torii, Y.; Kozaki, S.; Mukamoto, M.
Characterization of the functional activity of botulinum neurotoxin subtype B6
Microbiol. Immunol.
61
482-489
2017
Clostridium botulinum, Clostridium botulinum Osaka05
Moritz, M.S.; Tepp, W.H.; Bradshaw, M.; Johnson, E.A.; Pellett, S.
Isolation and characterization of the novel botulinum neurotoxin A subtype 6
mSphere
3
e00466-18
2018
Clostridium botulinum, Clostridium botulinum CDC41370
Zhang, S.; Masuyer, G.; Zhang, J.; Shen, Y.; Lundin, D.; Henriksson, L.; Miyashita, S.I.; Martinez-Carranza, M.; Dong, M.; Stenmark, P.
Identification and characterization of a novel botulinum neurotoxin
Nat. Commun.
8
14130
2017
Clostridium botulinum (P0DPK1)
Tao, L.; Peng, L.; Berntsson, R.P.; Liu, S.M.; Park, S.; Yu, F.; Boone, C.; Palan, S.; Beard, M.; Chabrier, P.E.; Stenmark, P.; Krupp, J.; Dong, M.
Engineered botulinum neurotoxin B with improved efficacy for targeting human receptors
Nat. Commun.
8
53
2017
Clostridium botulinum
Liu, Q.; Sinnen, B.L.; Boxer, E.E.; Schneider, M.W.; Grybko, M.J.; Buchta, W.C.; Gibson, E.S.; Wysoczynski, C.L.; Ford, C.P.; Gottschalk, A.; Aoto, J.; Tucker, C.L.; Kennedy, M.J.
A photoactivatable botulinum neurotoxin for inducible control of neurotransmission
Neuron
101
863-875.e6
2019
Clostridium botulinum (P10844)
Lam, K.H.; Sikorra, S.; Weisemann, J.; Maatsch, H.; Perry, K.; Rummel, A.; Binz, T.; Jin, R.
Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA
Pathog. Dis.
76
fty044
2018
Clostridium botulinum, Clostridium botulinum BCA10-7060
Kull, S.; Schulz, K.M.; Weisemann, J.; Kirchner, S.; Schreiber, T.; Bollenbach, A.; Dabrowski, P.W.; Nitsche, A.; Kalb, S.R.; Dorner, M.B.; Barr, J.R.; Rummel, A.; Dorner, B.G.
Isolation and functional characterization of the novel Clostridium botulinum neurotoxin A8 subtype
PLoS ONE
10
e0116381
2015
Clostridium botulinum, Clostridium botulinum Chemnitz
Chauhan, R.; Chauhan, V.; Rao, M.K.; Chaudhary, D.; Bhagyawant, S.; Dhaked, R.K.
High level expression and immunochemical characterization of botulinum neurotoxin type F light chain
Protein Expr. Purif.
146
51-60
2018
Clostridium botulinum
Dhaliwal, H.K.; Thiruvanakarasu, N.; Kumar, R.; Patel, K.; Ambrin, G.; Cai, S.; Singh, B.R.
High yield preparation of functionally active catalytic-translocation domain module of botulinum neurotoxin type A that exhibits uniquely different enzyme kinetics
Protein J.
36
489-501
2017
Clostridium botulinum
Elliott, M.; Favre-Guilmard, C.; Liu, S.M.; Maignel, J.; Masuyer, G.; Beard, M.; Boone, C.; Carre, D.; Kalinichev, M.; Lezmi, S.; Mir, I.; Nicoleau, C.; Palan, S.; Perier, C.; Raban, E.; Zhang, S.; Dong, M.; Stenmark, P.; Krupp, J.
Engineered botulinum neurotoxin B with improved binding to human receptors has enhanced efficacy in preclinical models
Sci. Adv.
5
eaau7196
2019
Clostridium botulinum
Masuyer, G.; Davies, J.R.; Moore, K.; Chaddock, J.A.; Ravi Acharya, K.
Structural analysis of Clostridium botulinum neurotoxin type D as a platform for the development of targeted secretion inhibitors
Sci. Rep.
5
13397
2015
Clostridium botulinum (P19321), Clostridium botulinum
Guo, J.; Chan, E.W.; Chen, S.
Mechanism of substrate recognition by the novel botulinum neurotoxin subtype F5
Sci. Rep.
6
19875
2016
Clostridium botulinum
Masuyer, G.; Zhang, S.; Barkho, S.; Shen, Y.; Henriksson, L.; Ko?enina, S.; Dong, M.; Stenmark, P.
Structural characterisation of the catalytic domain of botulinum neurotoxin X - high activity and unique substrate specificity
Sci. Rep.
8
4518
2018
Clostridium botulinum (P0DPK1)
Feltrup, T.M.; Patel, K.; Kumar, R.; Cai, S.; Singh, B.R.
A novel role of C-terminus in introducing a functionally flexible structure critical for the biological activity of botulinum neurotoxin
Sci. Rep.
8
8884
2018
Clostridium botulinum
Ambrin, G.; Kumar, R.; Singh, B.R.
Differential endopeptidase activity of different forms of type A botulinum neurotoxin A unique relationship between the size of the substrate and activity of the enzyme
Toxicon
144
34-41
2018
Clostridium botulinum
Hackett, G.; Moore, K.; Burgin, D.; Hornby, F.; Gray, B.; Elliott, M.; Mir, I.; Beard, M.
Purification and characterization of recombinant botulinum neurotoxin serotype FA, also known as serotype H
Toxins
10
E195
2018
Clostridium botulinum, Clostridium botulinum IBCA 10-7060
Sikorra, S.; Skiba, M.; Dorner, M.B.; Weisemann, J.; Weil, M.; Valdezate, S.; Davletov, B.; Rummel, A.; Dorner, B.G.; Binz, T.
Botulinum neurotoxin F subtypes cleaving the VAMP-2 Q58-K59 peptide bond exhibit unique catalytic properties and substrate specificities
Toxins
10
E311
2018
Clostridium botulinum (A0A1P8YWK9), Clostridium botulinum (A7GBG3), Clostridium botulinum (D2KHS4), Clostridium baratii (A0A1P8YWP1), Clostridium baratii CNM1212/11 (A0A1P8YWP1), Clostridium botulinum NCTC 10281 (A7GBG3), Clostridium botulinum H078-01 (A0A1P8YWK9), Clostridium botulinum H078-01 (D2KHS4)
Joussain, C.; Le Coz, O.; Pichugin, A.; Marconi, P.; Lim, F.; Sicurella, M.; Salonia, A.; Montorsi, F.; Wandosell, F.; Foster, K.; Giuliano, F.; Epstein, A.L.; Aranda Munoz, A.
Botulinum neurotoxin light chains expressed by defective herpes simplex virus type-1 vectors cleave SNARE proteins and inhibit CGRP release in rat sensory neurons
Toxins
11
E123
2019
Clostridium botulinum (P0DPI1), Clostridium botulinum (P19321), Clostridium botulinum (P30996), Clostridium botulinum (Q00496), Clostridium phage c-st (P18640), Clostridium botulinum ATCC 3502 (P0DPI1)
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