Inhibitors | Comment | Organism | Structure |
---|---|---|---|
captopril | - |
Clostridium sp. | |
EDTA | - |
Clostridium sp. |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zinc | zinc-dependent endopeptidase | Clostridium sp. |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
Synaptosome-associated protein + H2O | Clostridium sp. | i.e. SNAP 25, protein of presynaptic membrane | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium sp. | - |
F | - |
Clostridium sp. | - |
serotypes BoNT/A, B, D, E | - |
Clostridium sp. F | - |
F | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the botulinum neurotoxins are divided into two groups: the A-E type and the B-D-F-tetanus toxin type | Clostridium sp. | ? | - |
? | |
additional information | N-ethylmaleimide sensitive factor (i.e. NSF), alpha/beta-SNAP or gamma-SNAP | Clostridium sp. | ? | - |
? | |
additional information | the botulinum neurotoxins are divided into two groups: the A-E type and the B-D-F-tetanus toxin type | Clostridium sp. F | ? | - |
? | |
additional information | N-ethylmaleimide sensitive factor (i.e. NSF), alpha/beta-SNAP or gamma-SNAP | Clostridium sp. F | ? | - |
? | |
Synaptobrevin + H2O | i.e. VAMP, neuronal vesicle-associated membrane protein, MW 19000, with 2 isoforms in human, chicken, in rat brain: synaptobrevin/VAMP-1 and synaptobrevin/VAMP-2, cleaves at Gln76-Phe77, the same site as botulin neurotoxin B | Clostridium sp. | Hydrolyzed synaptobrevin | - |
? | |
Synaptobrevin + H2O | serotype BoNT/D: cleavage at Lys61-Leu62 | Clostridium sp. | Hydrolyzed synaptobrevin | - |
? | |
Synaptobrevin + H2O | carrying synaptobrevin/VAMP-2 | Clostridium sp. | Hydrolyzed synaptobrevin | - |
? | |
Synaptobrevin + H2O | both isoforms are cleaved at the same rate | Clostridium sp. | Hydrolyzed synaptobrevin | - |
? | |
Synaptobrevin + H2O | carrying Val76 instead of Gln76 is not hydrolyzed by serotype BoNT/B | Clostridium sp. | Hydrolyzed synaptobrevin | - |
? | |
Synaptobrevin + H2O | highly specific neurotoxins | Clostridium sp. | Hydrolyzed synaptobrevin | - |
? | |
Synaptobrevin + H2O | i.e. VAMP, neuronal vesicle-associated membrane protein, MW 19000, with 2 isoforms in human, chicken, in rat brain: synaptobrevin/VAMP-1 and synaptobrevin/VAMP-2, cleaves at Gln76-Phe77, the same site as botulin neurotoxin B | Clostridium sp. F | Hydrolyzed synaptobrevin | - |
? | |
Synaptobrevin + H2O | serotype BoNT/D: cleavage at Lys61-Leu62 | Clostridium sp. F | Hydrolyzed synaptobrevin | - |
? | |
Synaptobrevin + H2O | carrying synaptobrevin/VAMP-2 | Clostridium sp. F | Hydrolyzed synaptobrevin | - |
? | |
Synaptosome-associated protein + H2O | serotype BoNT/A and E | Clostridium sp. | Hydrolyzed synaptosome-associated protein | - |
? | |
Synaptosome-associated protein + H2O | i.e. SNAP 25, protein of presynaptic membrane | Clostridium sp. | Hydrolyzed synaptosome-associated protein | - |
? | |
Synaptosome-associated protein + H2O | i.e. SNAP 25, protein of presynaptic membrane | Clostridium sp. | ? | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Clostridium sp. |