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Literature summary for 3.4.24.69 extracted from

  • Fang, H.; Luo, W.; Henkel, J.; Barbieri, J.; Green, N.
    A yeast assay probes the interaction between botulinum neurotoxin serotype B and its SNARE substrate (2006), Proc. Natl. Acad. Sci. USA, 103, 6958-6963.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
regulated expression of serotype B-LC in yeast leads to cleavage of the chimera and a conditional growth defect Clostridium botulinum

Protein Variants

Protein Variants Comment Organism
additional information construction and growth-selection of chimeric SNARE mutations that inhibit proteolysis, when these mutations are introduced into Sb and examined for cleavage, substrate residues located near and distal to the cleavage site are important, including residues positioned near the Sb transmembrane domain, overview, additional mutations in a nine-residue SNARE motif Clostridium botulinum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Clostridium botulinum LC-mediated proteolysis of SNARE proteins and consequent inhibition of synaptic vesicle fusion to the presynaptic membrane of human motor neurons are responsible for flaccid paralysis associated with botulism ?
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Organism

Organism UniProt Comment Textmining
Clostridium botulinum
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information LC-mediated proteolysis of SNARE proteins and consequent inhibition of synaptic vesicle fusion to the presynaptic membrane of human motor neurons are responsible for flaccid paralysis associated with botulism Clostridium botulinum ?
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 ?
additional information LC-mediated proteolysis of soluble N-ethylmaleimide-sensitive factor attachment protein receptor, i.e. SNARE, proteins, complex reaction mechanism, overview Clostridium botulinum ?
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Sb-Snc2p fusion protein + H2O a recombinant chimeric SNARE protein where a portion of neuronal synaptobrevin, Sb, is fused to Snc2p, a Sb ortholog required for protein secretion from yeast cells Clostridium botulinum ?
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 ?

Synonyms

Synonyms Comment Organism
botulinum neurotoxin serotype B
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 Clostridium botulinum