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Literature summary for 3.4.24.69 extracted from

  • Capkova, K.; Hixon, M.; Pellett, S.; Barbieri, J.; Johnson, E.; Janda, K.
    Benzylidene cyclopentenediones: First irreversible inhibitors against botulinum neurotoxin As zinc endopeptidase (2010), Bioorg. Med. Chem. Lett., 20, 206-208.
    View publication on PubMedView publication on EuropePMC
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Inhibitors

Inhibitors Comment Organism Structure
(2E)-3-(2,4-dichlorophenyl)-N-hydroxyprop-2-enamide
-
 Clostridium botulinum
(2E)-3-(4-chloro-2-methylphenyl)-N-hydroxyprop-2-enamide
-
 Clostridium botulinum
1-(2,4-dichlorobenzyl)-1H-pyrrole-2,5-dione inhibitor is providing relatively potent BoNT protection in a cellular assay. It inhibits the biological activity of BoNT/A1 in neuronal cells. This inhibitor is about 7 to 10times more potent than 2-(2,4-dichlorobenzylidene)cyclopent-4-ene-1,3-dione Clostridium botulinum
2-(2,4-dichlorobenzylidene)cyclopent-4-ene-1,3-dione inhibits the biological activity of BoNT/A1 in neuronal cells. This inhibitor is about 7 to 10times less potent than 1-(2,4-dichlorobenzyl)-1H-pyrrole-2,5-dione Clostridium botulinum
N-hydroxy-4-pentylbenzamide
-
 Clostridium botulinum

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SNAP-25 + H2O
-
 Clostridium botulinum ?
-
 ?

Synonyms

Synonyms Comment Organism
BoNT/A
-
 Clostridium botulinum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Clostridium botulinum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0008
-
 pH not specified in the publication, temperature not specified in the publication Clostridium botulinum (2E)-3-(4-chloro-2-methylphenyl)-N-hydroxyprop-2-enamide
0.0009
-
 pH not specified in the publication, temperature not specified in the publication Clostridium botulinum (2E)-3-(2,4-dichlorophenyl)-N-hydroxyprop-2-enamide
0.041
-
 pH not specified in the publication, temperature not specified in the publication Clostridium botulinum N-hydroxy-4-pentylbenzamide