Literature summary for 3.4.24.69 extracted from

Binz, T.; Kurazono, H.; Popoff, M.R.; Eklund, M.W.; Sakaguchi, G.; Kozaki, S.; Krieglstein, K.; Henschen, A.; Gill, D.M.; Niemann, H.
Nucleotide sequence of the gene encoding Clostridium botulinum neurotoxin type D (1990), Nucleic Acids Res., 18, 5556.

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Cloned(Commentary)

Cloned (Comment)	Organism
C1	Clostridium botulinum
Clostridium botulinum	Clostridium botulinum
D	Clostridium botulinum

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
146900	-	Clostridium botulinum, serotype BoNT/D, calculated from nucleotide sequence	Clostridium botulinum

Organism

Organism	UniProt	Comment	Textmining
Clostridium botulinum	-	7 serologically different neurotoxin types: BoNT/A-G	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Proteins of neuroexocytosis apparatus + H2O	-	Clostridium botulinum	?	-	?

Subunits

Subunits	Comment	Organism
More	synthesized as single-chain polypeptide of about MW 150000 Da, proteolytic activation yields 2-chain neurotoxin with N-terminal light (MW 50000 Da) and C-terminal heavy chains (MW 100000 Da) connected by single disulfide bonds	Clostridium botulinum

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Release 2023.1 (January 2023)