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Literature summary for 3.4.24.69 extracted from

  • Capkova, K.; Yoneda, Y.; Dickerson, T.J.; Janda, K.D.
    Synthesis and structure-activity relationships of second-generation hydroxamate botulinum neurotoxin A protease inhibitors (2007), Bioorg. Med. Chem. Lett., 17, 6463-6466.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.69

Inhibitors

Inhibitors Comment Organism Structure
(2E)-3-(2-amino-4-chlorophenyl)-N-hydroxyprop-2-enamide
-
 Clostridium botulinum
(2E)-3-(2-bromo-4-chlorophenyl)-N-hydroxyprop-2-enamide
-
 Clostridium botulinum
(2E)-3-(4-chloro-2-fluorophenyl)-N-hydroxyprop-2-enamide
-
 Clostridium botulinum
(2E)-3-(4-chloro-2-hydroxyphenyl)-N-hydroxyprop-2-enamide
-
 Clostridium botulinum
(2E)-3-(4-chloro-2-methoxyphenyl)-N-hydroxyprop-2-enamide
-
 Clostridium botulinum
(2E)-3-(4-chloro-2-methylphenyl)-N-hydroxyprop-2-enamide
-
 Clostridium botulinum
(2E)-3-(4-chloro-2-nitrophenyl)-N-hydroxyprop-2-enamide
-
 Clostridium botulinum
(2E)-3-[4-chloro-2-(iminomethyl)phenyl]-N-hydroxyprop-2-enamide
-
 Clostridium botulinum
(2E)-3-[4-chloro-2-(methylsulfanyl)phenyl]-N-hydroxyprop-2-enamide
-
 Clostridium botulinum
(2E)-3-[4-chloro-2-(methylsulfonyl)phenyl]-N-hydroxyprop-2-enamide
-
 Clostridium botulinum
(2E)-3-[4-chloro-2-(trifluoromethyl)phenyl]-N-hydroxyprop-2-enamide
-
 Clostridium botulinum
2,4-dichlorocinnamic acid hydroxamate
-
 Clostridium botulinum
2-bromo-4-chlorocinnamic acid hydroxamate
-
 Clostridium botulinum
2-methyl-4-chlorocinnamic acid hydroxamate
-
 Clostridium botulinum
2-trifluoromethyl-4-chlorocinnamic acid hydroxamate
-
 Clostridium botulinum
4-chlorocinnamic hydroxamate
-
 Clostridium botulinum
6-bromo-N-hydroxynaphthalene-2-carboxamide
-
 Clostridium botulinum
6-chloro-N-hydroxy-1-benzothiophene-2-carboxamide
-
 Clostridium botulinum
6-chloro-N-hydroxy-1-methyl-1H-indole-2-carboxamide
-
 Clostridium botulinum
6-chloro-N-hydroxy-1H-indene-2-carboxamide
-
 Clostridium botulinum
6-chloro-N-hydroxynaphthalene-2-carboxamide
-
 Clostridium botulinum

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
-
-
-

Synonyms

Synonyms Comment Organism
BoNT/A
-
 Clostridium botulinum
botulinum neurotoxin A protease
-
 Clostridium botulinum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0006
-
-
 Clostridium botulinum (2E)-3-[4-chloro-2-(trifluoromethyl)phenyl]-N-hydroxyprop-2-enamide
0.0007
-
-
 Clostridium botulinum (2E)-3-(2-bromo-4-chlorophenyl)-N-hydroxyprop-2-enamide
0.0008
-
-
 Clostridium botulinum (2E)-3-(4-chloro-2-methylphenyl)-N-hydroxyprop-2-enamide
0.0009
-
-
 Clostridium botulinum 2,4-dichlorocinnamic acid hydroxamate
0.002
-
-
 Clostridium botulinum (2E)-3-(4-chloro-2-nitrophenyl)-N-hydroxyprop-2-enamide
0.0044
-
-
 Clostridium botulinum (2E)-3-(4-chloro-2-fluorophenyl)-N-hydroxyprop-2-enamide
0.0051
-
-
 Clostridium botulinum (2E)-3-[4-chloro-2-(methylsulfanyl)phenyl]-N-hydroxyprop-2-enamide
0.009
-
-
 Clostridium botulinum (2E)-3-(4-chloro-2-methoxyphenyl)-N-hydroxyprop-2-enamide
0.012
-
-
 Clostridium botulinum (2E)-3-[4-chloro-2-(iminomethyl)phenyl]-N-hydroxyprop-2-enamide
0.013
-
-
 Clostridium botulinum (2E)-3-(4-chloro-2-hydroxyphenyl)-N-hydroxyprop-2-enamide
0.015
-
-
 Clostridium botulinum 4-chlorocinnamic hydroxamate
0.017
-
-
 Clostridium botulinum (2E)-3-[4-chloro-2-(methylsulfonyl)phenyl]-N-hydroxyprop-2-enamide
0.021
-
-
 Clostridium botulinum 6-chloro-N-hydroxynaphthalene-2-carboxamide
0.025
-
-
 Clostridium botulinum (2E)-3-(2-amino-4-chlorophenyl)-N-hydroxyprop-2-enamide
0.038
-
-
 Clostridium botulinum 6-chloro-N-hydroxy-1-methyl-1H-indole-2-carboxamide
0.041
-
-
 Clostridium botulinum 6-chloro-N-hydroxy-1H-indene-2-carboxamide
0.045
-
-
 Clostridium botulinum 6-chloro-N-hydroxy-1-benzothiophene-2-carboxamide
0.071
-
-
 Clostridium botulinum 6-bromo-N-hydroxynaphthalene-2-carboxamide