Application | Comment | Organism |
---|---|---|
medicine | process development for production of a candidate vaccine antigen by recombinant expression of the C-terminal heavy chain fragment of botulinum neurotoxin serotype E Pichia pastoris strain GS115 | Clostridium botulinum |
Cloned (Comment) | Organism |
---|---|
cell bank construction, expression of the C-terminal heavy chain fragment of botulinum neurotoxin serotype E in Pichia pastoris strain GS115, method development and evaluation using the pHILD4 Escherichia coli-Pichia pastoris shuttle plasmid, fermentation up-scaling, modeling, overview | Clostridium botulinum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
SNAP25 + H2O | Clostridium botulinum | i.e. synaptosome-associated protein of 25 kDa, located at the host synaptic membrane, serotype E toxin cleaving SNAP25 prevents assembly of the synaptic fusion complex and therefore the fusion of the acetylcholine-containing vesicle and the synaptic membrane | ? | - |
? | |
SNAP25 + H2O | Clostridium botulinum NCTC 11219 | i.e. synaptosome-associated protein of 25 kDa, located at the host synaptic membrane, serotype E toxin cleaving SNAP25 prevents assembly of the synaptic fusion complex and therefore the fusion of the acetylcholine-containing vesicle and the synaptic membrane | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Clostridium botulinum | - |
- |
- |
Clostridium botulinum NCTC 11219 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
SNAP25 + H2O | i.e. synaptosome-associated protein of 25 kDa, located at the host synaptic membrane, serotype E toxin cleaving SNAP25 prevents assembly of the synaptic fusion complex and therefore the fusion of the acetylcholine-containing vesicle and the synaptic membrane | Clostridium botulinum | ? | - |
? | |
SNAP25 + H2O | i.e. synaptosome-associated protein of 25 kDa, located at the host synaptic membrane | Clostridium botulinum | ? | - |
? | |
SNAP25 + H2O | i.e. synaptosome-associated protein of 25 kDa, located at the host synaptic membrane, serotype E toxin cleaving SNAP25 prevents assembly of the synaptic fusion complex and therefore the fusion of the acetylcholine-containing vesicle and the synaptic membrane | Clostridium botulinum NCTC 11219 | ? | - |
? | |
SNAP25 + H2O | i.e. synaptosome-associated protein of 25 kDa, located at the host synaptic membrane | Clostridium botulinum NCTC 11219 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
antigen E | - |
Clostridium botulinum |
BoNTE | - |
Clostridium botulinum |
botulinum neurotoxin serotype E | - |
Clostridium botulinum |
HCE | - |
Clostridium botulinum |