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Literature summary for 3.4.24.69 extracted from

  • Schmidt, J.J.; Stafford, R.G.
    A high-affinity competitive inhibitor of type A botulinum neurotoxin protease activity (2002), FEBS Lett., 532, 423-426.
    View publication on PubMed
Search for more literature for 3.4.24.69

Application

Application Comment Organism
medicine drug to treat certain muscle dysfunctions Clostridium botulinum

Inhibitors

Inhibitors Comment Organism Structure
2-mercapto-3-phenylpropionyl-R
-
 Clostridium botulinum
2-mercapto-3-phenylpropionyl-RA
-
 Clostridium botulinum
2-mercapto-3-phenylpropionyl-RAAKML
-
 Clostridium botulinum
2-mercapto-3-phenylpropionyl-RAT
-
 Clostridium botulinum
2-mercapto-3-phenylpropionyl-RATAML
-
 Clostridium botulinum
2-mercapto-3-phenylpropionyl-RATK
-
 Clostridium botulinum
2-mercapto-3-phenylpropionyl-RATKAL
-
 Clostridium botulinum
2-mercapto-3-phenylpropionyl-RATKM
-
 Clostridium botulinum
2-mercapto-3-phenylpropionyl-RATKML
-
 Clostridium botulinum
2-mercapto-3-phenylpropionyl-RATKMLGSG
-
 Clostridium botulinum
2-mercapto-3-phenylpropionyl-RVTKML
-
 Clostridium botulinum
N-acetyl-CRATKML-amide
-
 Clostridium botulinum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
50000
-
 1 * 50000 + 1 * 100000, light chain and heavy chain, covalently linked by a disulfide bond Clostridium botulinum
100000
-
 1 * 50000 + 1 * 100000, light chain and heavy chain, covalently linked by a disulfide bond Clostridium botulinum

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SNAP-25 + H2O synaptosomal associated protein Clostridium botulinum ?
-
 ?

Subunits

Subunits Comment Organism
dimer 1 * 50000 + 1 * 100000, light chain and heavy chain, covalently linked by a disulfide bond Clostridium botulinum

Synonyms

Synonyms Comment Organism
BoNT A
-
 Clostridium botulinum
type A botulinum neurotoxin protease
-
 Clostridium botulinum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0003
-
 2-mercapto-3-phenylpropionyl-RATKM pH 7.3, 37°C Clostridium botulinum
0.0003
-
 2-mercapto-3-phenylpropionyl-RATKML pH 7.3, 37°C Clostridium botulinum
0.0003
-
 2-mercapto-3-phenylpropionyl-RATKMLGSG pH 7.3, 37°C Clostridium botulinum
0.0007
-
 2-mercapto-3-phenylpropionyl-RATKAL pH 7.3, 37°C Clostridium botulinum
0.0007
-
 2-mercapto-3-phenylpropionyl-RAAKML pH 7.3, 37°C Clostridium botulinum
0.002
-
 2-mercapto-3-phenylpropionyl-RVTKML pH 7.3, 37°C Clostridium botulinum
0.003
-
 2-mercapto-3-phenylpropionyl-RATAML pH 7.3, 37°C Clostridium botulinum
0.004
-
 2-mercapto-3-phenylpropionyl-RATK pH 7.3, 37°C Clostridium botulinum
0.03
-
 2-mercapto-3-phenylpropionyl-RAT pH 7.3, 37°C Clostridium botulinum
0.06
-
 2-mercapto-3-phenylpropionyl-R pH 7.3, 37°C Clostridium botulinum
0.06
-
 2-mercapto-3-phenylpropionyl-RA pH 7.3, 37°C Clostridium botulinum