Literature summary for 3.4.24.69 extracted from

Shi, J.; Li, T.; Hou, X.; Cai, K.; Bao, S.; Liu, H.; Gao, X.; Xiao, L.; Tu, W.; Wang, Q.; Yin, J.; Wang, H.
Recombinant luminal domain of human synaptotagmin II in combination with gangliosides inhibits the toxicity of botulinum neurotoxins in mice (2010), Microbes Infect., 12, 319-323.

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Inhibitors

Inhibitors	Comment	Organism	Structure
synaptotagmin II luminal domain	the luminal domain of syt II, syt II-LD, inhibits the toxicity of BoNT/B by interfering with the toxin-receptor interaction. It contains toxin-binding sites that have a high affinity for BoNT/B heavy chain. Recombinant syt II-LD in vivo provides protection against BoNT/B intoxication in mice models to about 30% survivals at 0.27 mg/ml of sytII-LD, the neutralization effect is improved by using gangliosides to 60% survivals. Syt II-LD specifically binds to BoNT/B compared to other BoNT serotypes, overview	Clostridium botulinum

Organism

Organism	UniProt	Comment	Textmining
Clostridium botulinum	-	-	-

Synonyms

Synonyms	Comment	Organism
BoNT/B	-	Clostridium botulinum
botulinum neurotoxin B	-	Clostridium botulinum

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
22	-	assay at room temperature	Clostridium botulinum

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Clostridium botulinum

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Release 2023.1 (January 2023)