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Literature summary for 3.4.24.69 extracted from

  • Feltrup, T.M.; Patel, K.; Kumar, R.; Cai, S.; Singh, B.R.
    A novel role of C-terminus in introducing a functionally flexible structure critical for the biological activity of botulinum neurotoxin (2018), Sci. Rep., 8, 8884 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.24.69

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL-21(DE3)-RIL cells Clostridium botulinum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
synaptosome-associated protein SNAP-25 + H2O Clostridium botulinum
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Ni-NTA column chromatography Clostridium botulinum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Nutide + H2O i.e. FITC(bA)T(dR)IDQANQRAT(K/DABCYL)(Nle)-amide Clostridium botulinum ?
-
 ?
synaptosome-associated protein SNAP-25 + H2O
-
 Clostridium botulinum ?
-
 ?

Synonyms

Synonyms Comment Organism
BoNT/A
-
 Clostridium botulinum
botulinum neurotoxin a
-
 Clostridium botulinum
LCA botulinum neurotoxin A light chain Clostridium botulinum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
 Clostridium botulinum

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
25 37 the enzyme shows 33% activity at 25°C compared to it optimum at 37°C Clostridium botulinum