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Literature summary for 3.4.24.69 extracted from

  • Schiavo, G.; Santucci, A.; DasGupta, B.R.; Mehta, P.P.; Jontes, J.; Benfenati, F.; Wilson, M.C.; Montecucco, C.
    Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds (1993), FEBS Lett., 335, 99-103.
    View publication on PubMed
Search for more literature for 3.4.24.69

Metals/Ions

Metals/Ions Comment Organism Structure
Zinc zinc-dependent endopeptidase Clostridium botulinum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
synaptobrevin + H2O Clostridium botulinum i.e. VAMP ?
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 ?
synaptobrevin + H2O Clostridium botulinum synaptic vesicle-associated membrane protein, neurotoxin responsible for human and animal botulism ?
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 ?

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Synaptobrevin + H2O i.e. VAMP, neuronal vesicle-associated membrane protein, MW 19000, with 2 isoforms in human, chicken, in rat brain: synaptobrevin/VAMP-1 and synaptobrevin/VAMP-2, cleaves at Gln76-Phe77, the same site as botulin neurotoxin B Clostridium botulinum Hydrolyzed synaptobrevin
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 ?
Synaptobrevin + H2O no substrate of serotype BoNT/A or E Clostridium botulinum Hydrolyzed synaptobrevin
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 ?
synaptobrevin + H2O i.e. VAMP Clostridium botulinum ?
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 ?
synaptobrevin + H2O synaptic vesicle-associated membrane protein, neurotoxin responsible for human and animal botulism Clostridium botulinum ?
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 ?
Synaptosome-associated protein + H2O highly specific neurotoxins Clostridium botulinum Hydrolyzed synaptosome-associated protein
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 ?
Synaptosome-associated protein + H2O serotype BoNT/A and E Clostridium botulinum Hydrolyzed synaptosome-associated protein
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 ?
Synaptosome-associated protein + H2O in vitro, in isolated synaptosomes Clostridium botulinum Hydrolyzed synaptosome-associated protein
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 ?
Synaptosome-associated protein + H2O serotype BoNT/E: cleavage at Arg180-Ile181 Clostridium botulinum Hydrolyzed synaptosome-associated protein
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 ?
Synaptosome-associated protein + H2O native and recombinant protein Clostridium botulinum Hydrolyzed synaptosome-associated protein
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 ?
Synaptosome-associated protein + H2O serotype BoNT/A: cleavage at Gln197-Arg198 Clostridium botulinum Hydrolyzed synaptosome-associated protein
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 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Clostridium botulinum