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Literature summary for 3.4.24.69 extracted from

  • Minnow, Y.V.; Goldberg, R.; Tummalapalli, S.R.; Rotella, D.P.; Goodey, N.M.
    Mechanism of inhibition of botulinum neurotoxin type A light chain by two quinolinol compounds (2017), Arch. Biochem. Biophys., 618, 15-22 .
    View publication on PubMed
Search for more literature for 3.4.24.69

Inhibitors

Inhibitors Comment Organism Structure
4-chloro-(3-fluorophenyl)methyl benzenesulfonamide i.e. MSU84, competitive inhibitor of botulinum neurotoxin type A light chain Clostridium botulinum
4-chloro-N-[(4-fluorophenyl)methyl] pyridin-3-amine i.e. MSU58, competitive inhibitor of botulinum neurotoxin type A light chain Clostridium botulinum

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.045
-
 SNAPtide at pH 7.4 and 25°C Clostridium botulinum

Organism

Organism UniProt Comment Textmining
Clostridium botulinum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
SNAPtide + H2O
-
 Clostridium botulinum ?
-
 ?

Synonyms

Synonyms Comment Organism
BoNT/A
-
 Clostridium botulinum
botulinum neurotoxin type A
-
 Clostridium botulinum

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.21
-
 SNAPtide at pH 7.4 and 25°C Clostridium botulinum

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0032
-
 4-chloro-N-[(4-fluorophenyl)methyl] pyridin-3-amine at pH 7.4 and 25°C Clostridium botulinum
0.0062
-
 4-chloro-(3-fluorophenyl)methyl benzenesulfonamide at pH 7.4 and 25°C Clostridium botulinum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0033
-
 at pH 7.4 and 25°C Clostridium botulinum 4-chloro-N-[(4-fluorophenyl)methyl] pyridin-3-amine
0.0058
-
 at pH 7.4 and 25°C Clostridium botulinum 4-chloro-(3-fluorophenyl)methyl benzenesulfonamide