3.5.2.6: beta-lactamase
This is an abbreviated version!
For detailed information about beta-lactamase, go to the full flat file.
Word Map on EC 3.5.2.6
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3.5.2.6
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pneumonia
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klebsiella
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enterobacteriaceae
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esbls
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carbapenems
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aeruginosa
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carbapenem-resistant
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ampicillin
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esbl-producing
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multidrug-resistant
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enterobacter
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cefotaxime
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ceftazidime
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aureus
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acinetobacter
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surveillance
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meropenem
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nosocomial
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clavulanic
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microbiological
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haemophilus
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aminoglycosides
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ciprofloxacin
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baumannii
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cloacae
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tetracycline
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pulsed-field
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outbreak
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disk
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gentamicin
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integrons
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plasmid-mediated
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colistin
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amikacin
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ceftriaxone
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fluoroquinolones
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microdilution
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quinolone
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citrobacter
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proteus
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multilocus
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carriage
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mirabilis
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gonorrhoeae
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staphylococci
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community-acquired
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third-generation
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methicillin
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penicillin-binding
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enterococci
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drug development
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synthesis
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diagnostics
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medicine
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pharmacology
- 3.5.2.6
- pneumonia
- klebsiella
- enterobacteriaceae
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esbls
- carbapenems
- aeruginosa
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carbapenem-resistant
- ampicillin
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esbl-producing
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multidrug-resistant
- enterobacter
- cefotaxime
- ceftazidime
- aureus
- acinetobacter
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surveillance
- meropenem
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nosocomial
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clavulanic
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microbiological
- haemophilus
- aminoglycosides
- ciprofloxacin
- baumannii
- cloacae
- tetracycline
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pulsed-field
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outbreak
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disk
- gentamicin
- integrons
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plasmid-mediated
- colistin
- amikacin
- ceftriaxone
- fluoroquinolones
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microdilution
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quinolone
- citrobacter
- proteus
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multilocus
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carriage
- mirabilis
- gonorrhoeae
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staphylococci
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community-acquired
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third-generation
- methicillin
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penicillin-binding
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enterococci
- drug development
- synthesis
- diagnostics
- medicine
- pharmacology
Reaction
Synonyms
ACT-3, ALI-1, Ambler class A beta-lactamase, AmpC, AmpC beta-lactamase, AmpC beta-lactamases M19, AmpC beta-lactamases M29, AmpC beta-lactamases M37, AmpC M19, AmpC M29, AmpC M37, AmpC-A, AmpC-B2, AmpC-type beta-lactamase, apo Bacillus cereus 569/H/9 enzyme, apo-BcII, B1 metallo-beta-lactamase, B3 MBL, BcII, BCL-1, BEL-1, Beta lactamase OXA-10, beta-lactamase, beta-lactamase A-C, beta-lactamase ACT-1, beta-lactamase AME I, beta-lactamase Bla-A, beta-lactamase Bla-B, beta-lactamase CMY-1, beta-lactamase CMY-2, beta-lactamase I-III, beta-lactamase II, beta-lactamase MIR-1, beta-lactamase OXA-1, beta-lactamase OXA-10, beta-lactamase P99, beta-lactamase PSE-1, beta-lactamase YRC-1, beta-lactamase, class C, beta-lactamases CTX-M-25, beta-lactamases CTX-M-26, beta-lactamse A-D, BLA, Bla-A, Bla-B, Bla1, Bla2, BlaA, blaACT-12, blaACT-14, blaACT-15, blaACT-17, blaACT-18, blaACT-19, blaACT-22, BlaB, BlaC, blaCMY-126, blaCMY-2, blaCMY-65, blaCMY-66, blaCMY-67, blaCMY-68, blaCMY-70, blaCMY-71, blaCMY-74, blaCMY-83, blaCMY-93, blaCTX-M-14, blaCTX-M-15, blaCTX-M-27, blaCTX-M-55, BLAIMP, blaIMP-4, blaKPC-2, blaLUT-1, BlaMab, blaNDM-1, blaNDM-7, blaoxa-1, blaSHV-1, blaSHV-14, blaTEM-1, blaToho-11, blaVIM-2, BS3, CAR-1 enzyme, CARB-3, carbapenem-hydrolysing MBL, carbapenem-hydrolyzing ambler class D beta-lactamase, carbapenem-hydrolyzing class A beta-lactamase, carbapenemase, carbapenemase CphA, Carbenicillinase, CcrA, cefotaximase, ceftazidimase, cefurooximase, Cefuroximase, Cephalosporinase, cephamycinase, CIA-1, CKO, class A beta-lactamase, class A beta-lactamase CKO-1, class A beta-lactamase CKO-2, class A beta-lactamase CKO-3, class A beta-lactamase CKO-4, class A TEM-2 beta-lactamase, class A TEM-2 enzyme, class B beta-lactamase SFB-1, class B beta-lactamase SLB-1, class B carbapenemase, class B metallo-beta-lactamase, class B metallo-beta-lactamase L-1, class C beta-lactamase, class C cephalosporinase, class C P99 beta-lactamase, class D beta lactamase, class D beta-lactamase, class D OXA-1 beta-lactamase, class D oxacillinase, CMY-1, CMY-10, CMY-2-type beta-lactamase, CMY-37, CphA, CTX-M beta-lactamase, CTX-M-1, CTX-M-14, CTX-M-64, CTX-M-64 beta-lactamase, EC 3.5.2.8, ESBL, Est-Y29, EstSRT1, exo-small beta-lactamase, extended spectrum beta-lactamase, extended-spectrum beta-lactamase, extended-spectrum beta-lactamase TEM-60, extended-spectrum-beta-lactamase, FEZ-1 metallo-beta-lactamase, FOX-4, FUS-1, GC1 beta-lactamase, GES-1, GES-2, GES-5, GES-type beta-lactamase, GIM-1, Imipenem-cefoxitin hydrolyzing enzyme, imipenemase, ImiS, IMP-1, IMP-10, IMP-12, IMP-13, IMP-15, IMP-16, IMP-18, IMP-2, IMP-2 MBL, IMP-9-type metallo-beta-lactamase, IMP-like metallo-beta-lactamase, IMP-type beta-lactamase, IMP-type metallo-beta-lactamase, IND-5, KHM-1, KLUA-9, KPC beta-lactamase, KPC-2, KPC-2 beta-lactamase, KPC-3, L1, L1 beta-lactamase, L1 metallo-beta-lactamase, L2 beta-lactamase, LHK-5, LUT-1 beta-lactamase, M19, M29, M37, MacQ, MbetaL, mbetal L1, MBL, metagenome-derived family VIII carboxylesterase, metallo-beta -lactamase, metallo-beta-L-lactamase, metallo-beta-lactamase, metallo-beta-lactamase BceII, metallo-beta-lactamase BcII, metallo-beta-lactamase ImiS, metallo-beta-lactamase IMP-1, metallo-beta-lactamase L1, metallo-beta-lactamase type 2, metallo-beta-lactamase VIM-1, metallo-beta-lactamase VIM-2, metallo-beta-lactamase VIM-6, MFO, MIR-4 beta-lactamase, More, Mox-1, Mox-1 beta-lactamase, MSMEG_4455, NDM, NDM-1, NDM-10, NDM-12, NDM-2, NDM-3, NDM-4, NDM-5, NDM-6, NDM-7, NDM-8, NDM-9, neutrapen, New Delhi MbetaL-1, New Delhi MBL, New Delhi metallo-beta-lactamase, New Delhi metallo-beta-lactamase-1, OXA group I, OXA group II, OXA-1, oxa-1 beta-lactamase, OXA-10, OXA-10 beta-lactamase, OXA-10 enzyme, OXA-17, OXA-18, OXA-2, OXA-229, OXA-24, OXA-24 beta-lactamase, OXA-40, OXA-48 carbapenemase, Oxa-50, OXA-55, OXA-57, OXA-63, OXA-69, OXA-85, OXA-type metallo-beta-lactamase, OXA114, Oxacillinase, oxycillinase, P99, P99 beta-lactamase, PenA, PenB1 beta-lactamase, PenB2, PenB3, PenB4, penicillinase, penicillinase I, II, PenP, PER-1, PER-2, plasmidic class C beta-lactamase, POM-1, poxB, PSE-1, PSE-4, serine beta-lactamase, SFC-1, Sfh-I, SHV, SHV beta-lactamase, SHV-1, SHV-1 beta-lactamase, SHV-1 penicillinase, SHV-14 beta-lactamase, SHV-2A, SHV-4, SHV-5, SHV-55, SHV-type beta-lactamase, SHV-type extended spectrum beta-lactamase, SIM-1, SMB-1, SME-1, SPM-1, ST1585, subclass B1 metallo-?-lactamase, subclass B3 metallo-beta-lactamase, TEM, TEM extended-spectrum beta-lactamase, TEM-1, TEM-1 beta-lactamase, TEM-107, TEM-116, TEM-149, TEM-21, TEM-8, TEM-type beta-lactamase, TEM1, THIN-B metallo-beta-lactamase, TMB-1, Toho-1, TRU-1, Verona integron-encoded MBL, Verona integron-encoded MBL-2, VIM, VIM-1, VIM-1 metallo-beta-lactamase, VIM-11, VIM-12, VIM-13, VIM-2, VIM-2 metallo-beta-lactamase, VIM-3, VIM-4, VIM-5, VIM-6, VIM-6 enzyme, VIM-7, VIM-metallo beta-lactamase, VIM-type MBL, VIM-type metallo-beta-lactamase, zinc beta-lactamase, Zn-beta-lactamase
ECTree
3.5.2.6 beta-lactamaseAdvanced search results
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results (Organism
Organism on EC 3.5.2.6 - beta-lactamase
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ORGANISM 
COMMENTARY 
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
strain CIP69598, previously Alcaligenes xylosoxidans
UniProt
isolated from activated sludge in a penicillin G production wastewater treatment system
AB702957
GenBank
produces only one beta-lactamase belonging to molecular class C
UniProt
isolated from faecal samples of healthy humans of La Rioja region (Northern Spain), September to November 2010
UniProt
strain 254G9, strain 4952, strain 192c3, strain 2662, strain 3701, strain 3806 and strain 02C9
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subsp. atroseptica DSM 30184 (also recently named Pectobacterium atrosepticum)
UniProt
plasmid pQE32Chl17
the chloramphenicol acetyltransferase gene replaces the blaTEM-1 gene as the selectable marker, allowing plasmid maintenance using 0.0125 mg/ml chloramphenicol. The blaTEM-1 gene is then subcloned under control of the IPTG-inducible promoter and mutated. The resulting constructs harbor a 6-histidine tag that is N-terminal to the native TEM-1 signal peptide. Upon processing of the signal peptide during expression and maturation in Escherichia coli, the histidine tag is also removed
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gene blaIMP-1; blaIMP-cluster-producingstrains
UniProt
using the template blaSHV-1 gene in the phagemid vector pBC SK(-), degeneration of oligonucleotides at Ambler position 276 to make the full complement of amino acid substitutions. After PCR mutagenesis, electroporation of the resultant plasmids into Escherichia coli
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from genetically distinct carbapenem-resistant strains from Argentina
SwissProt
IMP-1 producing strains A3035, A4861, A3880, A68, A4764, A4468, A129046, A695 and A696, and SIM-1 producing strain YMC 03/9/T104
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209311, 209313, 209322, 209335, 209337, 209339, 209342, 209343, 209347, 209361, 209364, 654962, 663956, 664117
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isolated from faecal samples of healthy humans of La Rioja region (Northern Spain), September to November 2010
UniProt
isolated from faecal samples of healthy humans of La Rioja region (Northern Spain), September to November 2010
UniProt
VIM-1 producing strains 75-10344, ECL3 and ECL4, and IMP-1 producing strain 199
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a clinical strain isolated from a patient with a urinary tract infection in Spain, gene blaFOX-4
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isolated from chicken carcasses and human infection in a restrict area
UniProt
multidrug resistant extended-spectrum beta-lactamase-producing Escherichia coli among uropathogens of pediatrics in north of Iran
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gene blaCMY-2; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012
UniProt
gene blaCTX-M-15; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012
UniProt
gene blaIMP-4; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012
UniProt
gene blaKPC-2; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012
UniProt
gene blaNDM-1; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012
UniProt
the recombinant plasmid pVT-1 is used as a source of the blaOXA-48 gene. The blaOXA-48 ORF is subcloned into expression vector pET-9a to yield recombinant plasmid pET-OXA-48. Escherichia coli MCT236(DE3) is used as the host for overproduction of the OXA-48 enzyme
UniProt
12 multidrug-resistant Pseudomonas aeruginosa, MDRPA, isolates isolated in the National Bone Marrow Transplant Centre of Tunisia, genes blaSHV-1 and blaOXA-18
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19 strains isolated from seven immunocompromised patients, and 3 strains isolated from environmental swabs, genes blaOXA18 and blaSHV
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an isolate from Turkey co-expressing extended-spectrum beta-lactamase PER-1 and metallo-beta-lactamase VIM-2, strain YUS, genes blaPER-1 and blaVIM-2
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class A enzyme PSE-4, the active site structure involves Ser70, Lys73, Ser130, Glu166, Asn170, and Arg234 as catalytic residues
Uniprot
clinical human isolates from a Mexican tertiary-care hospital, strain 4677, gene blaVIM-1
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clinical human isolates from Majorca, Spain, e.g. strain PA-SL2, and strain PAO1, genes blaVIM-1 and blaVIM-13
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clinical human isolates of imipenem-resistant strains, genes blaIMP-1, blaVIM and blaVIM-2
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clinical isolates from human patients, gene bla-VIM in MBl variant VIM-2
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IMP-15; clinical human isolates from a Mexican tertiary-care hospital, strain 4677, gene blaIMP-15
UniProt
isolates from Korean human individuals, genes blaOXA-10, blaVIM-2, blaPSE-I, blaOXA-4, blaOXA-17, blaOXA-30
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metallo-beta-lactamase VIM-7; isolate from the USA, gene blaVIM-7
UniProt
MSC15369, IMP-1 is PCR amplified from plasmid DNA prepared from a carbapenems-resistant Pseudomonas aeruginosa MSC15369. The PCR product is cloned into pTrcHis2 TOPO vector (Invitrogen, Carlsbad, CA) and expressed in Escherichia coli DH5a after induction with 0.5 mM isopropyl-beta-D-(-)-thiogalactopyranoside for 3 h at room temperature
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strain ATCC 27853, IMP-1 producing strains 131, 144, 137, 98, 128, 130, 143, 145, 183, PSA320, IMP-13 producing strain 86-10079, IMP-16 producing strain 101-4704, IMP-18 producing strains 3486 and 3489, GIM-1 producing strain 73-5671, VIM-1 producing strain 179, VIM-2 producing strain 225 and VIM-7 producing strain 07-406, SPM-1 producing strains 48-1997 A, 14, 44, 73, 75, 76, 83, 194, 196 and 197
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strains P15 and P23, 2 imipenem-resistant isolates, gene oxa40 coding on a plasmid
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serovar Typhimurium, transferable plasmid blaPER-2 in a ceftibuten-resistant strain
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the blaSFC-1 gene is contained in the chromosome of Serratia fonticola UTAD54 and is absent from other Serratia fonticola strains
SwissProt
the blaSFC-1 gene is contained in the chromosome of Serratia fonticola UTAD54 and is absent from other Serratia fonticola strains
SwissProt
beta-lactamase domain, cf. EC 3.1.1.1; metagenome-derived family VIII carboxylesterase
UniProt
strain IP97. In the bla gene from strain IP97 a deletion of 51 bp results in a completely inactive beta-lactamase. In the ampC gene from strain Y56 the A751G mutation is responsible for the inactivation of beta-lactamase
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