Literature summary for 3.5.2.6 extracted from

Erne, A.M.; Zahner, H.; Werner, R.G.
Isolation and characterisation of the potent broad spectrum beta-lactamase AME 1 from Streptomyces antibioticus ssp. antibioticus (1983), FEMS Microbiol. Lett., 16, 117-121.

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Organism

Organism	UniProt	Comment	Textmining
Streptomyces antibioticus	-	strain antibioticus Tü1718, beta-lactamase AME 1	-

Purification (Commentary)

Purification (Comment)	Organism
-	Streptomyces antibioticus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ampicillin + H2O	-	Streptomyces antibioticus	(2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid	-	?
cefotaxime + H2O	-	Streptomyces antibioticus	(2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid	-	?
cefoxitin + H2O	-	Streptomyces antibioticus	(2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid	-	?
ceftazidime + H2O	-	Streptomyces antibioticus	(2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate	-	?
cephaloridine + H2O	-	Streptomyces antibioticus	(2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate	-	?
cephalothin + H2O	-	Streptomyces antibioticus	(2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid	-	?
cephamandol + H2O	-	Streptomyces antibioticus	2R)-2-[(R)-carboxy{[(2R)-2-hydroxy-2-phenylacetyl]amino}methyl]-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid	-	?
clavulanic acid + H2O	-	Streptomyces antibioticus	(2R,4R,5Z)-2-(carboxymethyl)-5-(2-hydroxyethylidene)-1,3-oxazolidine-4-carboxylic acid	-	?
cloxacillin + H2O	-	Streptomyces antibioticus	(2R,4S)-2-[(R)-carboxy{[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid	-	?
CP 45899 + H2O	-	Streptomyces antibioticus	(2R,4S)-2-(carboxymethyl)-5,5-dimethyl-1,1-dioxo-1lambda~6~,3-thiazolidine-4-carboxylic acid	-	?
L-valyl-(5S)-3,5-dihydroxylysine + H2O	-	Streptomyces antibioticus	?	-	?
moxalactam + H2O	-	Streptomyces antibioticus	(2R)-2-{(R)-carboxy[2-carboxy(4-hydroxyphenyl)acetamido]methoxymethyl}-5-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-3,6-dihydro-2H-1,3-oxazine-4-carboxylic acid	-	?

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Release 2023.1 (January 2023)