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Literature summary for 3.5.2.6 extracted from

  • Marchiaro, P.; Tomatis, P.E.; Mussi, M.A.; Pasteran, F.; Viale, A.M; Limansky, A.S.; Vila, A.J.
    Biochemical characterization of metallo-beta-lactamase VIM-11 from a Pseudomonas aeruginosa clinical strain (2007), Antimicrob. Agents Chemother., 52, 2250-2252.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli BL21(DE3) and DH5alpha cells Pseudomonas aeruginosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0045
-
cephalothin
-
Pseudomonas aeruginosa
0.0055
-
cefuroxime
-
Pseudomonas aeruginosa
0.0074
-
cefoxitin
-
Pseudomonas aeruginosa
0.0082
-
nitrocefin
-
Pseudomonas aeruginosa
0.0094
-
Imipenem
-
Pseudomonas aeruginosa
0.0114
-
cefotaxime
-
Pseudomonas aeruginosa
0.0153
-
benzylpenicillin
-
Pseudomonas aeruginosa
0.0227
-
meropenem
-
Pseudomonas aeruginosa
0.109
-
ampicillin
-
Pseudomonas aeruginosa
0.11
-
ceftazidime
-
Pseudomonas aeruginosa
0.183
-
cefpirome
-
Pseudomonas aeruginosa
1.2
-
cefepime
-
Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
-
-
-
Pseudomonas aeruginosa M5109
-
-
-

Purification (Commentary)

Purification (Comment) Organism
glutathione-agarose column chromatography Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ampicillin + H2O
-
Pseudomonas aeruginosa (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
ampicillin + H2O
-
Pseudomonas aeruginosa M5109 (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
benzylpenicillin + H2O
-
Pseudomonas aeruginosa (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
benzylpenicillin + H2O
-
Pseudomonas aeruginosa M5109 (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
cefepime + H2O
-
Pseudomonas aeruginosa (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cefotaxime + H2O
-
Pseudomonas aeruginosa (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefoxitin + H2O
-
Pseudomonas aeruginosa (2R)-5-[(carbamoyloxy)methyl]-2-[(S)-carboxy(methoxy)[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefpirome + H2O
-
Pseudomonas aeruginosa (2S)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-[(6,7-dihydro-5H-cyclopenta[b]pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
ceftazidime + H2O
-
Pseudomonas aeruginosa (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cefuroxime + H2O
-
Pseudomonas aeruginosa (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cefuroxime + H2O
-
Pseudomonas aeruginosa M5109 (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cephalothin + H2O
-
Pseudomonas aeruginosa (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
cephalothin + H2O
-
Pseudomonas aeruginosa M5109 (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
imipenem + H2O
-
Pseudomonas aeruginosa (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?
meropenem + H2O
-
Pseudomonas aeruginosa (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?
additional information does not hydrolyse aztreonam Pseudomonas aeruginosa ?
-
?
additional information does not hydrolyse aztreonam Pseudomonas aeruginosa M5109 ?
-
?
nitrocefin + H2O
-
Pseudomonas aeruginosa (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?

Synonyms

Synonyms Comment Organism
MbetaL
-
Pseudomonas aeruginosa
metallo-beta-lactamase
-
Pseudomonas aeruginosa
VIM-11
-
Pseudomonas aeruginosa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
3.2
-
meropenem
-
Pseudomonas aeruginosa
6.4
-
cefoxitin
-
Pseudomonas aeruginosa
14
-
ceftazidime
-
Pseudomonas aeruginosa
20
-
Imipenem
-
Pseudomonas aeruginosa
27
-
cefuroxime
-
Pseudomonas aeruginosa
41.3
-
cefotaxime
-
Pseudomonas aeruginosa
81
-
cephalothin
-
Pseudomonas aeruginosa
100
-
cefepime
-
Pseudomonas aeruginosa
102
-
cefpirome
-
Pseudomonas aeruginosa
113
-
benzylpenicillin
-
Pseudomonas aeruginosa
129
-
nitrocefin
-
Pseudomonas aeruginosa
190
-
ampicillin
-
Pseudomonas aeruginosa