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Literature summary for 3.5.2.6 extracted from

  • Poirel, L.; Brinas, L.; Verlinde, A.; Ide, L.; Nordmann, P.
    BEL-1, a novel clavulanic acid-inhibited extended-spectrum beta-lactamase, and the class 1 integron In120 in Pseudomonas aeruginosa (2005), Antimicrob. Agents Chemother., 49, 3743-3748.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.2.6

Cloned(Commentary)

Cloned (Comment) Organism
-
 Pseudomonas aeruginosa

Inhibitors

Inhibitors Comment Organism Structure
clavulanic acid
-
 Pseudomonas aeruginosa
Imipenem
-
 Pseudomonas aeruginosa
moxalactam
-
 Pseudomonas aeruginosa
Sulbactam
-
 Pseudomonas aeruginosa
tazobactam
-
 Pseudomonas aeruginosa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.008
-
 ticarcillin 30°C, pH 7.0 Pseudomonas aeruginosa
0.015
-
 piperacillin 30°C, pH 7.0 Pseudomonas aeruginosa
0.02
-
 benzylpenicillin 30°C, pH 7.0 Pseudomonas aeruginosa
0.03
-
 amoxicillin 30°C, pH 7.0 Pseudomonas aeruginosa
0.03
-
 ceftriaxone 30°C, pH 7.0 Pseudomonas aeruginosa
0.04
-
 cefuroxime 30°C, pH 7.0 Pseudomonas aeruginosa
0.1
-
 aztreonam 30°C, pH 7.0 Pseudomonas aeruginosa
0.13
-
 cephaloridine 30°C, pH 7.0 Pseudomonas aeruginosa
0.15
-
 cefepime 30°C, pH 7.0 Pseudomonas aeruginosa
0.15
-
 cefsulodine 30°C, pH 7.0 Pseudomonas aeruginosa
0.25
-
 cefotaxime 30°C, pH 7.0 Pseudomonas aeruginosa
0.28
-
 cephalothin 30°C, pH 7.0 Pseudomonas aeruginosa

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa Q3SAW3 clinical isolate 51170
-

Purification (Commentary)

Purification (Comment) Organism
-
 Pseudomonas aeruginosa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amoxicillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-{[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
aztreonam + H2O
-
 Pseudomonas aeruginosa [(1S,2S)-1-[[(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[[(2-carboxypropan-2-yl)oxy]imino]acetyl]amino]-1-carboxypropan-2-yl]sulfamate
-
 ?
benzylpenicillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
cefepime + H2O
-
 Pseudomonas aeruginosa (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
cefotaxime + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
cefsulodine + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(4-carbamoylpyridin-1-ium-1-yl)methyl]-2-[(R)-carboxy{[(2R)-2-phenyl-2-sulfoacetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
ceftriaxone + H2O
-
 Pseudomonas aeruginosa (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[[(6-hydroxy-2-methyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl)sulfanyl]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
cefuroxime + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
cephaloridine + H2O
-
 Pseudomonas aeruginosa (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
cephalothin + H2O
-
 Pseudomonas aeruginosa (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
piperacillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
ticarcillin + H2O
-
 Pseudomonas aeruginosa (2R,4S)-2-[(R)-carboxy[[(2R)-2-carboxy-2-(thiophen-3-yl)acetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Synonyms

Synonyms Comment Organism
BEL-1
-
 Pseudomonas aeruginosa

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1
-
 cefepime 30°C, pH 7.0 Pseudomonas aeruginosa
2
-
 piperacillin 30°C, pH 7.0 Pseudomonas aeruginosa
3
-
 benzylpenicillin 30°C, pH 7.0 Pseudomonas aeruginosa
6
-
 ticarcillin 30°C, pH 7.0 Pseudomonas aeruginosa
10
-
 cefuroxime 30°C, pH 7.0 Pseudomonas aeruginosa
10
-
 aztreonam 30°C, pH 7.0 Pseudomonas aeruginosa
10
-
 amoxicillin 30°C, pH 7.0 Pseudomonas aeruginosa
25
-
 ceftriaxone 30°C, pH 7.0 Pseudomonas aeruginosa
25
-
 cefsulodine 30°C, pH 7.0 Pseudomonas aeruginosa
30
-
 cefotaxime 30°C, pH 7.0 Pseudomonas aeruginosa
30
-
 cephaloridine 30°C, pH 7.0 Pseudomonas aeruginosa
150
-
 cephalothin 30°C, pH 7.0 Pseudomonas aeruginosa

pI Value

Organism Comment pI Value Maximum pI Value
Pseudomonas aeruginosa isoelectric focusing, pH-range 3.5-9.5
-
 8.5