Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.2.6 extracted from

  • Eliasson, I.; Kamme, C.; Vang, M.; Waley, S.G.
    Characterization of cell-bound papain-soluble beta-lactamases in BRO-1 and BRO-2 producing strains of Moraxella (Branhamella) catarrhalis and Moraxella nonliquefaciens (1992), Eur. J. Clin. Microbiol. Infect. Dis., 11, 313-321.
    View publication on PubMed
Search for more literature for 3.5.2.6

Inhibitors

Inhibitors Comment Organism Structure
6-beta-bromopenicillanic acid
-
 Moraxella catarrhalis
6-beta-bromopenicillanic acid
-
 Moraxella nonliquefaciens
clavulanic acid
-
 Moraxella catarrhalis
clavulanic acid
-
 Moraxella nonliquefaciens
additional information no inactivation by 3 mM EDTA Moraxella catarrhalis
additional information no inactivation by 3 mM EDTA Moraxella nonliquefaciens
Sulbactam
-
 Moraxella catarrhalis
Sulbactam
-
 Moraxella nonliquefaciens
tazobactam
-
 Moraxella catarrhalis
tazobactam
-
 Moraxella nonliquefaciens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0009
-
 cephalothin enzyme 1, BRO-1 Moraxella catarrhalis
0.0012
-
 cephalothin enzyme 2, BRO-2 Moraxella catarrhalis
0.0014
-
 Cloxacillin enzyme 1, BRO-1 Moraxella catarrhalis
0.0015
-
 Cloxacillin enzyme 2, BRO-2 Moraxella catarrhalis
0.0017
-
 cephaloridine enzyme 1, BRO-1 Moraxella catarrhalis
0.002
-
 ampicillin enzyme 1, BRO-1 Moraxella catarrhalis
0.0028
-
 cephaloridine enzyme 2, BRO-2 Moraxella catarrhalis
0.0029
-
 benzylpenicillin enzyme 2, BRO-2 Moraxella catarrhalis
0.003
-
 benzylpenicillin enzyme 1, BRO-1 Moraxella catarrhalis
0.003
-
 cephalosporin C enzyme 2, BRO-2 Moraxella catarrhalis
0.0039
-
 cephalosporin C enzyme 1, BRO-1 Moraxella catarrhalis
0.0046
-
 ampicillin enzyme 2, BRO-2 Moraxella catarrhalis
0.0058
-
 piperacillin enzyme 2, BRO-2 Moraxella catarrhalis
0.0063
-
 piperacillin enzyme 1, BRO-1 Moraxella catarrhalis
0.0069
-
 nitrocefin enzyme 1, BRO-1 Moraxella catarrhalis
0.011
-
 nitrocefin enzyme 2, BRO-2 Moraxella catarrhalis
0.026
-
 Methicillin enzyme 2, BRO-2 Moraxella catarrhalis
0.034
-
 Methicillin enzyme 1, BRO-1 Moraxella catarrhalis
0.034
-
 cefaclor enzyme 1, BRO-1 Moraxella catarrhalis
0.038
-
 Loracarbef enzyme 2, BRO-2 Moraxella catarrhalis
0.04
-
 mecillinam enzyme 1, BRO-1 Moraxella catarrhalis
0.043
-
 cefaclor enzyme 2, BRO-2 Moraxella catarrhalis
0.05
-
 Loracarbef enzyme 1, BRO-1 Moraxella catarrhalis
0.056
-
 cefuroxime enzyme 2, BRO-2 Moraxella catarrhalis
0.063
-
 mecillinam enzyme 2, BRO-2 Moraxella catarrhalis
0.068
-
 cefuroxime enzyme 1, BRO-1 Moraxella catarrhalis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
-
 Moraxella catarrhalis
28000
-
-
 Moraxella nonliquefaciens

Organism

Organism UniProt Comment Textmining
Moraxella catarrhalis
-
-
-
Moraxella nonliquefaciens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Moraxella catarrhalis
-
 Moraxella nonliquefaciens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
75.8
-
-
 Moraxella catarrhalis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amoxicillin + H2O
-
 Moraxella catarrhalis (2R,4S)-2-[(R)-[[(2R)-2-amino-2-(4-hydroxyphenyl)acetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
ampicillin + H2O
-
 Moraxella catarrhalis (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
benzylpenicillin + H2O
-
 Moraxella catarrhalis (2R,4S)-2-[(R)-carboxy(2-phenylacetamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
cefaclor + H2O
-
 Moraxella catarrhalis (2R)-2-[(R)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-5-chloro-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
cefuroxime + H2O
-
 Moraxella catarrhalis (2R)-5-[(carbamoyloxy)methyl]-2-[(R)-carboxy{[(2Z)-2-(furan-2-yl)-2-(methoxyimino)acetyl]amino}methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
cephaloridine + H2O
-
 Moraxella catarrhalis (2R)-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-5-(pyridinium-1-ylmethyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
cephalosporin C + H2O
-
 Moraxella catarrhalis N6-[(R)-{(2R)-5-[(acetyloxy)methyl]-4-carboxy-3,6-dihydro-2H-1,3-thiazin-2-yl}(carboxy)methyl]-6-oxo-D-lysine
-
 ?
cephalothin + H2O
-
 Moraxella catarrhalis (2R)-5-[(acetyloxy)methyl]-2-[(R)-carboxy[(thiophen-2-ylacetyl)amino]methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
cloxacillin + H2O
-
 Moraxella catarrhalis (2R,4S)-2-[(R)-carboxy{[3-(2-chlorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino}methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
loracarbef + H2O
-
 Moraxella catarrhalis (6R)-6-[(S)-{[(2R)-2-amino-2-phenylacetyl]amino}(carboxy)methyl]-3-chloro-1,4,5,6-tetrahydropyridine-2-carboxylic acid
-
 ?
mecillinam + H2O
-
 Moraxella catarrhalis (2R,4S)-2-[(R)-{(E)-[(azepan-1-yl)methylidene]amino}(carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
methicillin + H2O
-
 Moraxella catarrhalis (2R,4S)-2-[(R)-carboxy(2,6-dimethoxybenzamido)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?
nitrocefin + H2O
-
 Moraxella catarrhalis (2R)-2-{(R)-carboxy[2-(thiophen-2-yl)acetamido]methyl}-5-[(E)-2-(2,4-dinitrophenyl)ethenyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
 ?
piperacillin + H2O
-
 Moraxella catarrhalis (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1
-
 cefuroxime enzyme 1, BRO-1 Moraxella catarrhalis
4.6
-
 cephalothin enzyme 2, BRO-2 Moraxella catarrhalis
4.7
-
 cephalosporin C enzyme 2, BRO-2 Moraxella catarrhalis
4.8
-
 cephaloridine enzyme 1, BRO-1 Moraxella catarrhalis
4.8
-
 cefuroxime enzyme 2, BRO-2 Moraxella catarrhalis
4.9
-
 cephalothin enzyme 1, BRO-1 Moraxella catarrhalis
5
-
 cephalosporin C enzyme 1, BRO-1 Moraxella catarrhalis
5
-
 Cloxacillin enzyme 1, BRO-1 Moraxella catarrhalis
5.6
-
 cephaloridine enzyme 2, BRO-2 Moraxella catarrhalis
8.6
-
 Cloxacillin enzyme 2, BRO-2 Moraxella catarrhalis
29
-
 mecillinam enzyme 2, BRO-2 Moraxella catarrhalis
31
-
 mecillinam enzyme 1, BRO-1 Moraxella catarrhalis
32
-
 ampicillin enzyme 2, BRO-2 Moraxella catarrhalis
33
-
 ampicillin enzyme 1, BRO-1 Moraxella catarrhalis
40
-
 benzylpenicillin enzyme 1, BRO-1 Moraxella catarrhalis
41
-
 benzylpenicillin enzyme 2, BRO-2 Moraxella catarrhalis
47
-
 piperacillin enzyme 1, BRO-1 Moraxella catarrhalis
51
-
 piperacillin enzyme 2, BRO-2 Moraxella catarrhalis
65
-
 cefaclor enzyme 1, BRO-1 Moraxella catarrhalis
69
-
 cefaclor enzyme 2, BRO-2 Moraxella catarrhalis
79
-
 Loracarbef enzyme 1, BRO-1 Moraxella catarrhalis
95
-
 Loracarbef enzyme 2, BRO-2 Moraxella catarrhalis
151
-
 nitrocefin enzyme 1, BRO-1 Moraxella catarrhalis
168
-
 Methicillin enzyme 1, BRO-1 Moraxella catarrhalis
190
-
 Methicillin enzyme 2, BRO-2 Moraxella catarrhalis
233
-
 nitrocefin enzyme 2, BRO-2 Moraxella catarrhalis