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Literature summary for 3.5.2.6 extracted from

  • Picao, R.C.; Andrade, S.S.; Nicoletti, A.G.; Campana, E.H.; Moraes, G.C.; Mendes, R.E.; Gales, A.C.
    Metallo-beta-Lactamase detection: comparative evaluation of double-disk synergy versus combined disk tests for IMP, GIM, SIM, SPM or VIM-producing isolates (2008), J. Clin. Microbiol., 46, 2028-2037.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.2.6

Application

Application Comment Organism
medicine putative development of a screening of MBL producing strains by routine clinical microbiology laboratories. The detection of the MBL phenotype of resistance is of crucial importance for selecting the most appropriate therapy and applying infection control measures Enterobacter cloacae
medicine putative development of a screening of MBL producing strains by routine clinical microbiology laboratories. The detection of the MBL phenotype of resistance is of crucial importance for selecting the most appropriate therapy and applying infection control measures Pseudomonas aeruginosa
medicine putative development of a screening of MBL producing strains by routine clinical microbiology laboratories. The detection of the MBL phenotype of resistance is of crucial importance for selecting the most appropriate therapy and applying infection control measures Serratia marcescens
medicine putative development of a screening of MBL producing strains by routine clinical microbiology laboratories. The detection of the MBL phenotype of resistance is of crucial importance for selecting the most appropriate therapy and applying infection control measures Klebsiella pneumoniae
medicine putative development of a screening of MBL producing strains by routine clinical microbiology laboratories. The detection of the MBL phenotype of resistance is of crucial importance for selecting the most appropriate therapy and applying infection control measures. Pseudomonas putida
medicine putative development of a screening of MBL producing strains by routine clinical microbiology laborities. The detection of the MBL phenotype of resistance is of crucial importance for selecting the most appropriate therapy and applying infection control measures Acinetobacter sp.

Inhibitors

Inhibitors Comment Organism Structure
2-mercaptoethanol mercaptoethanol shows no growth inhibition activity on Pseudomonas aeruginosa ATCC 27583 at all tested concentrations between 7.0 and 55 mM Pseudomonas aeruginosa
EDTA EDTA, PHEN, and MET present weak bactericidal activity against Pseudomonas aeruginosa with substrate ceftazidime Pseudomonas aeruginosa
Mercaptoacetic acid mercaptoacetic acid demonstrates hydrolytic activity against imipenem but not against ceftazidime Pseudomonas aeruginosa
Mercaptopropionic acid 1.4 mM mercaptopropionic acid demonstrates hydrolytic activity against imipenem but not against ceftazidime, mercaptopropionic acid provided the best results by using imipenem as substrate Acinetobacter sp.
Mercaptopropionic acid 1.4 mM mercaptopropionic acid demonstrates hydrolytic activity against imipenem but not against ceftazidime, mercaptopropionic acid provided the best results by using imipenem as substrate Pseudomonas aeruginosa
additional information the bactericidal effect of inhibitors of MBL is not influenced by the production of the MBL variants IMP, VIM, SPM, GIM, or SIM Pseudomonas aeruginosa
Phenanthroline phenanthroline shows no growth inhibition activity on Pseudomonas aeruginosa ATCC 27583 at all tested concentrations between 1.0 and 8.0 mM Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a beta-lactam + H2O Enterobacter cloacae
-
 a substituted beta-amino acid
-
 ?
a beta-lactam + H2O Pseudomonas aeruginosa
-
 a substituted beta-amino acid
-
 ?
a beta-lactam + H2O Pseudomonas putida
-
 a substituted beta-amino acid
-
 ?
a beta-lactam + H2O Serratia marcescens
-
 a substituted beta-amino acid
-
 ?
a beta-lactam + H2O Klebsiella pneumoniae
-
 a substituted beta-amino acid
-
 ?
a beta-lactam + H2O Acinetobacter sp.
-
 a substituted beta-amino acid
-
 ?

Organism

Organism UniProt Comment Textmining
Acinetobacter sp.
-
 IMP-1 producing strains A3035, A4861, A3880, A68, A4764, A4468, A129046, A695 and A696, and SIM-1 producing strain YMC 03/9/T104
-
Enterobacter cloacae
-
 VIM-1 producing strains 75-10344, ECL3 and ECL4, and IMP-1 producing strain 199
-
Klebsiella pneumoniae
-
 IMP-1 producing strains KPN1 and KPN2
-
Pseudomonas aeruginosa
-
 strain ATCC 27853, IMP-1 producing strains 131, 144, 137, 98, 128, 130, 143, 145, 183, PSA320, IMP-13 producing strain 86-10079, IMP-16 producing strain 101-4704, IMP-18 producing strains 3486 and 3489, GIM-1 producing strain 73-5671, VIM-1 producing strain 179, VIM-2 producing strain 225 and VIM-7 producing strain 07-406, SPM-1 producing strains 48-1997 A, 14, 44, 73, 75, 76, 83, 194, 196 and 197
-
Pseudomonas putida
-
 IMP-1 producing strain 48-12346A
-
Serratia marcescens
-
 IMP-1 producing strain SM319
-

Source Tissue

Source Tissue Comment Organism Textmining
cell culture
-
 Enterobacter cloacae
-
cell culture
-
 Pseudomonas aeruginosa
-
cell culture
-
 Pseudomonas putida
-
cell culture
-
 Serratia marcescens
-
cell culture
-
 Klebsiella pneumoniae
-
cell culture
-
 Acinetobacter sp.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a beta-lactam + H2O
-
 Enterobacter cloacae a substituted beta-amino acid
-
 ?
a beta-lactam + H2O
-
 Pseudomonas aeruginosa a substituted beta-amino acid
-
 ?
a beta-lactam + H2O
-
 Pseudomonas putida a substituted beta-amino acid
-
 ?
a beta-lactam + H2O
-
 Serratia marcescens a substituted beta-amino acid
-
 ?
a beta-lactam + H2O
-
 Klebsiella pneumoniae a substituted beta-amino acid
-
 ?
a beta-lactam + H2O
-
 Acinetobacter sp. a substituted beta-amino acid
-
 ?
ceftazidime + H2O cephalosporin antibiotic Enterobacter cloacae (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
ceftazidime + H2O cephalosporin antibiotic Pseudomonas aeruginosa (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
ceftazidime + H2O cephalosporin antibiotic Pseudomonas putida (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
ceftazidime + H2O cephalosporin antibiotic Serratia marcescens (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
ceftazidime + H2O cephalosporin antibiotic Klebsiella pneumoniae (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
ceftazidime + H2O cephalosporin antibiotic Acinetobacter sp. (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
 ?
imipenem + H2O beta-lactam antibiotic Enterobacter cloacae (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
imipenem + H2O beta-lactam antibiotic Pseudomonas aeruginosa (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
imipenem + H2O beta-lactam antibiotic Pseudomonas putida (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
imipenem + H2O beta-lactam antibiotic Serratia marcescens (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
imipenem + H2O beta-lactam antibiotic Klebsiella pneumoniae (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?
imipenem + H2O beta-lactam antibiotic Acinetobacter sp. (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
 ?

Synonyms

Synonyms Comment Organism
GIM-1
-
 Pseudomonas aeruginosa
IMP-1
-
 Enterobacter cloacae
IMP-1
-
 Pseudomonas aeruginosa
IMP-1
-
 Pseudomonas putida
IMP-1
-
 Serratia marcescens
IMP-1
-
 Klebsiella pneumoniae
IMP-1
-
 Acinetobacter sp.
IMP-13
-
 Pseudomonas aeruginosa
IMP-16
-
 Pseudomonas aeruginosa
IMP-18
-
 Pseudomonas aeruginosa
MBL
-
 Enterobacter cloacae
MBL
-
 Pseudomonas aeruginosa
MBL
-
 Pseudomonas putida
MBL
-
 Serratia marcescens
MBL
-
 Klebsiella pneumoniae
MBL
-
 Acinetobacter sp.
metallo-beta-lactamase
-
 Enterobacter cloacae
metallo-beta-lactamase
-
 Pseudomonas aeruginosa
metallo-beta-lactamase
-
 Pseudomonas putida
metallo-beta-lactamase
-
 Serratia marcescens
metallo-beta-lactamase
-
 Klebsiella pneumoniae
metallo-beta-lactamase
-
 Acinetobacter sp.
SIM-1
-
 Acinetobacter sp.
SPM-1
-
 Pseudomonas aeruginosa
VIM-1
-
 Enterobacter cloacae
VIM-1
-
 Pseudomonas aeruginosa
VIM-2
-
 Pseudomonas aeruginosa
VIM-7
-
 Pseudomonas aeruginosa