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3.5.2.6: beta-lactamase

This is an abbreviated version!
For detailed information about beta-lactamase, go to the full flat file.

Word Map on EC 3.5.2.6

Reaction

A beta-lactam
+
H2O
=
a substituted beta-amino acid

Synonyms

ACT-3, ALI-1, Ambler class A beta-lactamase, AmpC, AmpC beta-lactamase, AmpC beta-lactamases M19, AmpC beta-lactamases M29, AmpC beta-lactamases M37, AmpC M19, AmpC M29, AmpC M37, AmpC-A, AmpC-B2, AmpC-type beta-lactamase, apo Bacillus cereus 569/H/9 enzyme, apo-BcII, B1 metallo-beta-lactamase, B3 MBL, BcII, BCL-1, BEL-1, Beta lactamase OXA-10, beta-lactamase, beta-lactamase A-C, beta-lactamase ACT-1, beta-lactamase AME I, beta-lactamase Bla-A, beta-lactamase Bla-B, beta-lactamase CMY-1, beta-lactamase CMY-2, beta-lactamase I-III, beta-lactamase II, beta-lactamase MIR-1, beta-lactamase OXA-1, beta-lactamase OXA-10, beta-lactamase P99, beta-lactamase PSE-1, beta-lactamase YRC-1, beta-lactamase, class C, beta-lactamases CTX-M-25, beta-lactamases CTX-M-26, beta-lactamse A-D, BLA, Bla-A, Bla-B, Bla1, Bla2, BlaA, blaACT-12, blaACT-14, blaACT-15, blaACT-17, blaACT-18, blaACT-19, blaACT-22, BlaB, BlaC, blaCMY-126, blaCMY-2, blaCMY-65, blaCMY-66, blaCMY-67, blaCMY-68, blaCMY-70, blaCMY-71, blaCMY-74, blaCMY-83, blaCMY-93, blaCTX-M-14, blaCTX-M-15, blaCTX-M-27, blaCTX-M-55, BLAIMP, blaIMP-4, blaKPC-2, blaLUT-1, BlaMab, blaNDM-1, blaNDM-7, blaoxa-1, blaSHV-1, blaSHV-14, blaTEM-1, blaToho-11, blaVIM-2, BS3, CAR-1 enzyme, CARB-3, carbapenem-hydrolysing MBL, carbapenem-hydrolyzing ambler class D beta-lactamase, carbapenem-hydrolyzing class A beta-lactamase, carbapenemase, carbapenemase CphA, Carbenicillinase, CcrA, cefotaximase, ceftazidimase, cefurooximase, Cefuroximase, Cephalosporinase, cephamycinase, CIA-1, CKO, class A beta-lactamase, class A beta-lactamase CKO-1, class A beta-lactamase CKO-2, class A beta-lactamase CKO-3, class A beta-lactamase CKO-4, class A TEM-2 beta-lactamase, class A TEM-2 enzyme, class B beta-lactamase SFB-1, class B beta-lactamase SLB-1, class B carbapenemase, class B metallo-beta-lactamase, class B metallo-beta-lactamase L-1, class C beta-lactamase, class C cephalosporinase, class C P99 beta-lactamase, class D beta lactamase, class D beta-lactamase, class D OXA-1 beta-lactamase, class D oxacillinase, CMY-1, CMY-10, CMY-2-type beta-lactamase, CMY-37, CphA, CTX-M beta-lactamase, CTX-M-1, CTX-M-14, CTX-M-64, CTX-M-64 beta-lactamase, EC 3.5.2.8, ESBL, Est-Y29, EstSRT1, exo-small beta-lactamase, extended spectrum beta-lactamase, extended-spectrum beta-lactamase, extended-spectrum beta-lactamase TEM-60, extended-spectrum-beta-lactamase, FEZ-1 metallo-beta-lactamase, FOX-4, FUS-1, GC1 beta-lactamase, GES-1, GES-2, GES-5, GES-type beta-lactamase, GIM-1, Imipenem-cefoxitin hydrolyzing enzyme, imipenemase, ImiS, IMP-1, IMP-10, IMP-12, IMP-13, IMP-15, IMP-16, IMP-18, IMP-2, IMP-2 MBL, IMP-9-type metallo-beta-lactamase, IMP-like metallo-beta-lactamase, IMP-type beta-lactamase, IMP-type metallo-beta-lactamase, IND-5, KHM-1, KLUA-9, KPC beta-lactamase, KPC-2, KPC-2 beta-lactamase, KPC-3, L1, L1 beta-lactamase, L1 metallo-beta-lactamase, L2 beta-lactamase, LHK-5, LUT-1 beta-lactamase, M19, M29, M37, MacQ, MbetaL, mbetal L1, MBL, metagenome-derived family VIII carboxylesterase, metallo-beta -lactamase, metallo-beta-L-lactamase, metallo-beta-lactamase, metallo-beta-lactamase BceII, metallo-beta-lactamase BcII, metallo-beta-lactamase ImiS, metallo-beta-lactamase IMP-1, metallo-beta-lactamase L1, metallo-beta-lactamase type 2, metallo-beta-lactamase VIM-1, metallo-beta-lactamase VIM-2, metallo-beta-lactamase VIM-6, MFO, MIR-4 beta-lactamase, More, Mox-1, Mox-1 beta-lactamase, MSMEG_4455, NDM, NDM-1, NDM-10, NDM-12, NDM-2, NDM-3, NDM-4, NDM-5, NDM-6, NDM-7, NDM-8, NDM-9, neutrapen, New Delhi MbetaL-1, New Delhi MBL, New Delhi metallo-beta-lactamase, New Delhi metallo-beta-lactamase-1, OXA group I, OXA group II, OXA-1, oxa-1 beta-lactamase, OXA-10, OXA-10 beta-lactamase, OXA-10 enzyme, OXA-17, OXA-18, OXA-2, OXA-229, OXA-24, OXA-24 beta-lactamase, OXA-40, OXA-48 carbapenemase, Oxa-50, OXA-55, OXA-57, OXA-63, OXA-69, OXA-85, OXA-type metallo-beta-lactamase, OXA114, Oxacillinase, oxycillinase, P99, P99 beta-lactamase, PenA, PenB1 beta-lactamase, PenB2, PenB3, PenB4, penicillinase, penicillinase I, II, PenP, PER-1, PER-2, plasmidic class C beta-lactamase, POM-1, poxB, PSE-1, PSE-4, serine beta-lactamase, SFC-1, Sfh-I, SHV, SHV beta-lactamase, SHV-1, SHV-1 beta-lactamase, SHV-1 penicillinase, SHV-14 beta-lactamase, SHV-2A, SHV-4, SHV-5, SHV-55, SHV-type beta-lactamase, SHV-type extended spectrum beta-lactamase, SIM-1, SMB-1, SME-1, SPM-1, ST1585, subclass B1 metallo-?-lactamase, subclass B3 metallo-beta-lactamase, TEM, TEM extended-spectrum beta-lactamase, TEM-1, TEM-1 beta-lactamase, TEM-107, TEM-116, TEM-149, TEM-21, TEM-8, TEM-type beta-lactamase, TEM1, THIN-B metallo-beta-lactamase, TMB-1, Toho-1, TRU-1, Verona integron-encoded MBL, Verona integron-encoded MBL-2, VIM, VIM-1, VIM-1 metallo-beta-lactamase, VIM-11, VIM-12, VIM-13, VIM-2, VIM-2 metallo-beta-lactamase, VIM-3, VIM-4, VIM-5, VIM-6, VIM-6 enzyme, VIM-7, VIM-metallo beta-lactamase, VIM-type MBL, VIM-type metallo-beta-lactamase, zinc beta-lactamase, Zn-beta-lactamase

ECTree

     3 Hydrolases
         3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
             3.5.2 In cyclic amides
                3.5.2.6 beta-lactamase

KM Value

KM Value on EC 3.5.2.6 - beta-lactamase

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0023 - 0.027
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
0.315 - 0.323
(6R,7R)-3-[(acetyloxy)methyl]-7-(formylamino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
1.45
(6R,7R)-3-[(acetyloxy)methyl]-7-(hydroxyamino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
0.29
(6R,7R)-3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
0.24
(6R,7R)-3-[(acetyloxy)methyl]-7-[formyl(hydroxy)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
0.005 - 0.06
(6R,7R)-3-[(acetyloxy)methyl]-7-[hydroxy(phenylacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
0.031 - 0.21
(6R,7R)-3-[(acetyloxy)methyl]-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
0.014 - 0.0154
(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
0.002 - 0.013
(6R,7S)-3-[(3-carboxy-4-nitro-phenyl)sulfanylmethyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo-[4.2.0]-oct-2-ene-2-carboxylic acid
0.366
(6R,7Z)-3-[(acetyloxy)methyl]-7-(hydroxyimino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
0.0045
(6R,7Z)-7-(hydroxyimino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5,5-dioxide
-
pH and temperature not specified in the publication
0.05 - 0.42
2,2-dimethyl-6beta-({[5-methyl-3-(2-chlorophenyl)isoxazol-4-yl]carbonyl}amino)penam-3alpha-carboxylic acid
0.032
3-([3-dibenzylamino-3-oxopropanoyl]oxy)benzoic acid
pH 7.5, 25°C
0.7
3-([3-[benzyl(methyl)amino]-3-oxopropanoyl]oxy)benzoic acid
pH 7.5, 25°C
0.13 - 0.23
3-([N-(phenylacetyl)glycyl]oxy)benzoic acid
0.13 - 0.59
3-([N-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]glycyl]oxy)benzoic acid
0.06
3-([[(2R)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid
pH 7.5, 25°C
2.8
3-([[(2S)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid
pH 7.5, 25°C
0.0026
3-([[2-benzyl-3-oxo-3-(benzylamino)propanoyl]oxy]methyl)benzoic acid
pH 7.5, 25°C
0.32
3-nitrophenyl (2S)-2-hydroxy-3-phenylpropanoate
pH not specified in the publication, temperature not specified in the publication
0.046 - 0.059
3-[2-(2-aminothiazol-4-yl)2-(Z)-methoxyiminoacetylglycyl]oxybenzoic acid
0.172
3-[[(2S)-2-hydroxy-3-phenylpropanoyl]oxy]benzoic acid
pH not specified in the publication, temperature not specified in the publication
0.0166 - 1.5
6-aminopenicillanic acid
0.043
6-beta-iodopenicillanate
-
-
0.14
7-(thienyl-2-acetamido)-3-[2-(4-,N,N-dimethylaminophenylazo)pyridinium-methyl]-3-cephem-4-carboxylic acid
-
wild type
0.075
7-(thienyl-2-acetamido)-3-[2-(4-N,N-dimethylaminophenylazo)pyridinium-methyl]-3-cephem-4-carboxylic acid
-
-
0.29
7-aminocephalosporanic acid
pH 7.5, 25°C
0.00649 - 2.6
amoxicillin
0.035 - 0.22
amoxycillin
0.00001 - 76
ampicillin
0.06 - 0.066
azlocillin
0.000004 - 6
aztreonam
0.34
benzyl [[(2R)-2-hydroxy-3-phenylpropanoyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
0.46
benzyl [[(2S)-2-hydroxy-2-phenylacetyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
0.071
benzyl [[(2S)-2-hydroxy-3-phenylpropanoyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
0.02
benzyl [[(2S)-2-hydroxy-4-phenylbutanoyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
0.52
benzyl [[(2S)-2-hydroxypropanoyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
0.05
benzylcephalosporin C
-
both strains
0.00025 - 10
benzylpenicillin
0.032 - 1.5
biapenem
36.46 - 58.28
Bocillin-FL
0.26
carbencillin
-
pH 7.5, 37°C
0.002 - 1.28
carbenicillin
0.008 - 0.55
cefaclor
0.25
cefadroxil
-
-
0.096 - 0.8
cefaloridine
0.008 - 0.08
cefalothin
0.005 - 0.433
cefalotin
0.0032 - 0.2
cefamandole
0.018 - 1.5
cefazolin
0.025
cefcapene
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
0.0008
cefdinir
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
0.0008 - 75
cefepime
0.004
cefmetazole
-
-
0.0012 - 0.167
cefoperazone
0.0000009 - 45
cefotaxime
0.08
cefotetan
-
-
0.015 - 0.055
cefotiam
0.0000011 - 1.57
cefoxitin
0.021 - 0.67
cefpirome
0.03
cefsulodin
-
-
0.15
cefsulodine
30°C, pH 7.0
0.394
ceftaxidime
at 30°C in 100 mM sodium phosphate buffer, pH 7.0
0.00012 - 270
ceftazidime
0.008
ceftizoxime
-
-
0.006 - 0.95
ceftriaxone
0.028
ceftriazone
-
-
0.114
cefttriaxone
-
-
0.0000011 - 5.1
cefuroxime
0.023 - 0.195
CENTA
0.0017 - 4.53
cephalexin
2.86 - 3.84
cephaloglycin
0.43
cephaloridin
30°C, pH 7.0
0.0017 - 950
cephaloridine
0.003 - 3.33
cephalosporin C
0.0009 - 106
cephalothin
0.0001 - 0.9
cephalotin
0.0052 - 0.0795
cephapirin
0.015 - 0.26
cephradine
0.022
clavulanic acid
-
-
0.0000005 - 0.86
Cloxacillin
0.0002 - 0.151
doripenem
0.0002 - 0.6
ertapenem
0.013 - 0.12
faropenem
0.00005 - 32
Imipenem
0.038 - 0.05
Loracarbef
0.04 - 0.063
mecillinam
0.00003 - 4.5
meropenem
0.00023 - 2
Methicillin
0.015
mezlocillin
-
-
0.005 - 2.4
moxalactam
0.0012 - 18
nitrocefin
0.0000006 - 36
Oxacillin
0.014 - 0.102
panipenem
0.046 - 0.113
penicillin
0.0017 - 1.34
penicillin G
0.069
Penicillin V
-
in 100 mM MES (pH 6.4)
0.003 - 0.1
phenoxymethylpenicillin
0.00017 - 4
piperacillin
0.00047 - 1.3
Sulbactam
1.8
tazobactam
-
0.0008
tebipenem
pH 6.5, 22°C, recombinant enzyme
0.045
temocillin
pH 7.0, 30°C
0.006 - 2.8
ticarcillin
additional information
cefepime