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0.0023 - 0.027
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
0.315 - 0.323
(6R,7R)-3-[(acetyloxy)methyl]-7-(formylamino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
1.45
(6R,7R)-3-[(acetyloxy)methyl]-7-(hydroxyamino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
0.29
(6R,7R)-3-[(acetyloxy)methyl]-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
0.24
(6R,7R)-3-[(acetyloxy)methyl]-7-[formyl(hydroxy)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
0.005 - 0.06
(6R,7R)-3-[(acetyloxy)methyl]-7-[hydroxy(phenylacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
0.031 - 0.21
(6R,7R)-3-[(acetyloxy)methyl]-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
0.014 - 0.0154
(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
0.002 - 0.013
(6R,7S)-3-[(3-carboxy-4-nitro-phenyl)sulfanylmethyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo-[4.2.0]-oct-2-ene-2-carboxylic acid
0.366
(6R,7Z)-3-[(acetyloxy)methyl]-7-(hydroxyimino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
0.0045
(6R,7Z)-7-(hydroxyimino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 5,5-dioxide
-
pH and temperature not specified in the publication
0.05 - 0.42
2,2-dimethyl-6beta-({[5-methyl-3-(2-chlorophenyl)isoxazol-4-yl]carbonyl}amino)penam-3alpha-carboxylic acid
0.032
3-([3-dibenzylamino-3-oxopropanoyl]oxy)benzoic acid
pH 7.5, 25°C
0.7
3-([3-[benzyl(methyl)amino]-3-oxopropanoyl]oxy)benzoic acid
pH 7.5, 25°C
0.13 - 0.23
3-([N-(phenylacetyl)glycyl]oxy)benzoic acid
0.13 - 0.59
3-([N-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]glycyl]oxy)benzoic acid
0.06
3-([[(2R)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid
pH 7.5, 25°C
2.8
3-([[(2S)-3-(benzylamino)-2-methyl-3-oxopropanoyl]oxy]methyl)benzoic acid
pH 7.5, 25°C
0.0026
3-([[2-benzyl-3-oxo-3-(benzylamino)propanoyl]oxy]methyl)benzoic acid
pH 7.5, 25°C
0.32
3-nitrophenyl (2S)-2-hydroxy-3-phenylpropanoate
pH not specified in the publication, temperature not specified in the publication
0.046 - 0.059
3-[2-(2-aminothiazol-4-yl)2-(Z)-methoxyiminoacetylglycyl]oxybenzoic acid
0.172
3-[[(2S)-2-hydroxy-3-phenylpropanoyl]oxy]benzoic acid
pH not specified in the publication, temperature not specified in the publication
0.0166 - 1.5
6-aminopenicillanic acid
0.043
6-beta-iodopenicillanate
-
-
0.14
7-(thienyl-2-acetamido)-3-[2-(4-,N,N-dimethylaminophenylazo)pyridinium-methyl]-3-cephem-4-carboxylic acid
-
wild type
0.075
7-(thienyl-2-acetamido)-3-[2-(4-N,N-dimethylaminophenylazo)pyridinium-methyl]-3-cephem-4-carboxylic acid
-
-
0.29
7-aminocephalosporanic acid
pH 7.5, 25°C
0.00649 - 2.6
amoxicillin
0.34
benzyl [[(2R)-2-hydroxy-3-phenylpropanoyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
0.46
benzyl [[(2S)-2-hydroxy-2-phenylacetyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
0.071
benzyl [[(2S)-2-hydroxy-3-phenylpropanoyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
0.02
benzyl [[(2S)-2-hydroxy-4-phenylbutanoyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
0.52
benzyl [[(2S)-2-hydroxypropanoyl]oxy]carbamate
pH not specified in the publication, temperature not specified in the publication
0.05
benzylcephalosporin C
-
both strains
0.00025 - 10
benzylpenicillin
36.46 - 58.28
Bocillin-FL
0.26
carbencillin
-
pH 7.5, 37°C
0.002 - 1.28
carbenicillin
0.025
cefcapene
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
0.0008
cefdinir
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
0.0012 - 0.167
cefoperazone
0.0000009 - 45
cefotaxime
0.0000011 - 1.57
cefoxitin
0.15
cefsulodine
30°C, pH 7.0
0.394
ceftaxidime
at 30°C in 100 mM sodium phosphate buffer, pH 7.0
0.00012 - 270
ceftazidime
0.0000011 - 5.1
cefuroxime
2.86 - 3.84
cephaloglycin
0.43
cephaloridin
30°C, pH 7.0
0.0017 - 950
cephaloridine
0.003 - 3.33
cephalosporin C
0.0052 - 0.0795
cephapirin
0.022
clavulanic acid
-
-
0.0000005 - 0.86
Cloxacillin
0.0017 - 1.34
penicillin G
0.069
Penicillin V
-
in 100 mM MES (pH 6.4)
0.003 - 0.1
phenoxymethylpenicillin
0.0008
tebipenem
pH 6.5, 22°C, recombinant enzyme
0.045
temocillin
pH 7.0, 30°C
additional information
cefepime
0.0023
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
beta-lactamases CTX-M-25
0.027
(2S,5R,6R)-6-[[(2R)-2-carboxy-2-thiophen-3-ylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
beta-lactamases CTX-M-26
0.315
(6R,7R)-3-[(acetyloxy)methyl]-7-(formylamino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
0.323
(6R,7R)-3-[(acetyloxy)methyl]-7-(formylamino)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
0.005
(6R,7R)-3-[(acetyloxy)methyl]-7-[hydroxy(phenylacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
0.06
(6R,7R)-3-[(acetyloxy)methyl]-7-[hydroxy(phenylacetyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
0.031
(6R,7R)-3-[(acetyloxy)methyl]-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
-
wild-type enzyme
0.21
(6R,7R)-3-[(acetyloxy)methyl]-7-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
-
mutant enzyme S164R
0.014
(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
0.0154
(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
-
pH and temperature not specified in the publication
0.002
(6R,7S)-3-[(3-carboxy-4-nitro-phenyl)sulfanylmethyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo-[4.2.0]-oct-2-ene-2-carboxylic acid
D66N mutant, pH 7.4, room temperature
0.0024
(6R,7S)-3-[(3-carboxy-4-nitro-phenyl)sulfanylmethyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo-[4.2.0]-oct-2-ene-2-carboxylic acid
wild type, pH 7.4, room temperature
0.0032
(6R,7S)-3-[(3-carboxy-4-nitro-phenyl)sulfanylmethyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo-[4.2.0]-oct-2-ene-2-carboxylic acid
D66M mutant, pH 7.4, room temperature
0.006
(6R,7S)-3-[(3-carboxy-4-nitro-phenyl)sulfanylmethyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo-[4.2.0]-oct-2-ene-2-carboxylic acid
D66W mutant, pH 7.4, room temperature
0.007
(6R,7S)-3-[(3-carboxy-4-nitro-phenyl)sulfanylmethyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo-[4.2.0]-oct-2-ene-2-carboxylic acid
D66Y mutant, pH 7.4, room temperature
0.013
(6R,7S)-3-[(3-carboxy-4-nitro-phenyl)sulfanylmethyl]-8-oxo-7-[(2-thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo-[4.2.0]-oct-2-ene-2-carboxylic acid
D66A mutant, pH 7.4, room temperature
0.05
2,2-dimethyl-6beta-({[5-methyl-3-(2-chlorophenyl)isoxazol-4-yl]carbonyl}amino)penam-3alpha-carboxylic acid
-
-
0.087
2,2-dimethyl-6beta-({[5-methyl-3-(2-chlorophenyl)isoxazol-4-yl]carbonyl}amino)penam-3alpha-carboxylic acid
-
-
0.155
2,2-dimethyl-6beta-({[5-methyl-3-(2-chlorophenyl)isoxazol-4-yl]carbonyl}amino)penam-3alpha-carboxylic acid
-
penicillinase I
0.159
2,2-dimethyl-6beta-({[5-methyl-3-(2-chlorophenyl)isoxazol-4-yl]carbonyl}amino)penam-3alpha-carboxylic acid
-
penicillinase II
0.25
2,2-dimethyl-6beta-({[5-methyl-3-(2-chlorophenyl)isoxazol-4-yl]carbonyl}amino)penam-3alpha-carboxylic acid
-
-
0.42
2,2-dimethyl-6beta-({[5-methyl-3-(2-chlorophenyl)isoxazol-4-yl]carbonyl}amino)penam-3alpha-carboxylic acid
-
-
0.13
3-([N-(phenylacetyl)glycyl]oxy)benzoic acid
-
pH 7.5, 25°C, strain GCI
0.23
3-([N-(phenylacetyl)glycyl]oxy)benzoic acid
-
pH 7.5, 25°C, strain P99
0.13
3-([N-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]glycyl]oxy)benzoic acid
-
GC1 beta-lactamase
0.59
3-([N-[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]glycyl]oxy)benzoic acid
-
P99 beta-lactamase
0.046
3-[2-(2-aminothiazol-4-yl)2-(Z)-methoxyiminoacetylglycyl]oxybenzoic acid
-
pH 7.5, 25°C, strain GCI
0.059
3-[2-(2-aminothiazol-4-yl)2-(Z)-methoxyiminoacetylglycyl]oxybenzoic acid
-
pH 7.5, 25°C, strain P99
0.0166
6-aminopenicillanic acid
-
both strains
0.35
6-aminopenicillanic acid
-
-
1.5
6-aminopenicillanic acid
-
-
0.00649
amoxicillin
pH 8.0, 30°C, recombinant wild-type enzyme
0.02
amoxicillin
pH and temperature not specified in the publication
0.022
amoxicillin
at 30°C in 100 mM sodium phosphate (pH 7)
0.022
amoxicillin
-
in 100 mM MES (pH 6.4)
0.03
amoxicillin
30°C, pH 7.0
0.041
amoxicillin
pH 7.5, 25°C, recombinant His-tagged mutant E164A
0.05414
amoxicillin
pH 7.5, 25°C, recombinant His-tagged mutant E162A
0.0697
amoxicillin
pH 7.5, 25°C, recombinant His-tagged wild-type enzyme
0.19
amoxicillin
30°C, pH 7.0
0.405
amoxicillin
30°C, pH not specified in the publication
2.6
amoxicillin
30°C, pH 7.0
0.035
amoxycillin
-
-
0.00001
ampicillin
-
at 30°C in 50 mM sodium phosphate buffer (pH 7.0)
0.00006
ampicillin
in 20 mM phosphate buffer, (pH 7.0) at 30°C
0.00008
ampicillin
30°C, pH 7.0
0.00008
ampicillin
in 20 mM phosphate buffer, (pH 7.0) at 30°C
0.00013
ampicillin
30°C, pH 7.0
0.00013
ampicillin
in 20 mM phosphate buffer, (pH 7.0) at 30°C
0.00016
ampicillin
-
30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1
0.00016
ampicillin
-
30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2
0.00072
ampicillin
pH 7.0, 30°C
0.001
ampicillin
pH 7.0, 30°C
0.0017
ampicillin
-
30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1
0.002
ampicillin
-
enzyme 1, BRO-1
0.0022
ampicillin
-
30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1
0.0027
ampicillin
D66Y mutant, pH 7.4, room temperature
0.004
ampicillin
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.0042
ampicillin
-
mutant enzyme K104E
0.0046
ampicillin
-
enzyme 2, BRO-2
0.005
ampicillin
100 microM nitrocefin as the reporter substrate, TEM-149 wild-type, pH 7.0, 25°C
0.0051
ampicillin
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.006
ampicillin
-
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.006
ampicillin
D66A mutant, pH 7.4, room temperature
0.0062
ampicillin
37°C, pH 7.0
0.0077
ampicillin
beta-lactamases CTX-M-25
0.008
ampicillin
-
in 100 mM MES (pH 6.4)
0.009
ampicillin
-
wild-type enzyme
0.00954
ampicillin
pH 8.0, 30°C, recombinant wild-type enzyme
0.012
ampicillin
D66M mutant, pH 7.4, room temperature
0.015
ampicillin
-
in 0.01 M phosphate buffer (pH 7.0), at 25°C
0.019
ampicillin
100 microM nitrocefin as the reporter substrate, TEM-149 mutant T182M, pH 7.0, 25°C
0.0195
ampicillin
37°C, pH 7.0
0.02
ampicillin
25°C, pH 7.0
0.021
ampicillin
D66W mutant, pH 7.4, room temperature
0.021
ampicillin
wild type, pH 7.4, room temperature
0.023
ampicillin
D66N mutant, pH 7.4, room temperature
0.023
ampicillin
pH not specified in the publication, 30°C, recombinant enzyme
0.024
ampicillin
37°C, pH 7.0
0.024
ampicillin
beta-lactamases CTX-M-26
0.024
ampicillin
plasmid pBG66
-
pH and temperature not specified in the publication, mutant enzyme N166A/N170G
0.027
ampicillin
pH 7.2, 25°C
0.029
ampicillin
wild type OXA-1, pH 7.4, room temperature
0.03
ampicillin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.032
ampicillin
pH 7.5, 25°C, recombinant His-tagged wild-type enzyme
0.033
ampicillin
pH 7.0, 30°C, wild-type enzyme
0.035
ampicillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.036
ampicillin
His6-tagged wild type OXA-1, pH 7.4, room temperature
0.038
ampicillin
plasmid pBG66
-
pH and temperature not specified in the publication, wild-type enzyme
0.0389
ampicillin
-
mutant enzyme D170N
0.04
ampicillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.043
ampicillin
at 25°C in 100 mM sodium phosphate (pH 7.0)
0.055
ampicillin
wild-type enzyme, pH 7.0, 25°C
0.056
ampicillin
plasmid pBG66
-
pH and temperature not specified in the publication, mutant enzyme N170G
0.06
ampicillin
-
pH 7.5, 37°C
0.06
ampicillin
30°C, pH 7.0
0.06
ampicillin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.063
ampicillin
-
at 30°C
0.064
ampicillin
-
pH and temperature not specified in the publication
0.064
ampicillin
-
pH and temperature not specified in the publication, OXA-1 beta-lactamase
0.0719
ampicillin
-
wild-type enzyme
0.074
ampicillin
pH 7.0, 30°C, mutant R234K
0.1
ampicillin
30°C, pH 7.0
0.103
ampicillin
pH 7.5, 30°C
0.11
ampicillin
pH 7.2, 25°C, recombinant enzyme
0.114
ampicillin
-
penicillinase II
0.122
ampicillin
-
beta-lactamase C
0.125
ampicillin
plasmid pGEM-T-easy
-
mutant enzyme W154F, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.127
ampicillin
30°C, pH not specified in the publication
0.129
ampicillin
-
beta-lactamase D
0.13
ampicillin
plasmid pBG66
-
pH and temperature not specified in the publication, mutant enzyme N170A
0.131
ampicillin
-
penicillinase I
0.134
ampicillin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
0.15
ampicillin
in 30 mM sodium cacodylate buffer (pH 6.5) plus 0.05 mM ZnSO4
0.15
ampicillin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.156
ampicillin
pH 7.2, 25°C, recombinant enzyme
0.157
ampicillin
-
mutant enzyme K232N
0.16
ampicillin
-
beta-lactamase B
0.176
ampicillin
-
at 25°C in 50 mM sodium phosphate (pH 7.0)
0.18
ampicillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.183
ampicillin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
0.207
ampicillin
pH 7.2, 25°C, recombinant enzyme
0.21
ampicillin
pH 7.5, 37°C
0.21
ampicillin
-
wild type
0.229
ampicillin
pH 7.2, 25°C, recombinant enzyme
0.23
ampicillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.24
ampicillin
30°C, pH 7.0
0.25
ampicillin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.255
ampicillin
-
beta-lactamase A
0.258
ampicillin
pH 7.2, 25°C, recombinant enzyme
0.305
ampicillin
pH 7.2, 25°C, recombinant enzyme
0.335
ampicillin
-
mutant enzyme S164R
0.395
ampicillin
pH 7.0, 30°C
0.414
ampicillin
pH 7.5, 25°C, recombinant His-tagged mutant E162A
0.45
ampicillin
-
mutant enzyme P51L
0.455
ampicillin
pH 7.2, 25°C, recombinant enzyme
0.5
ampicillin
-
beta-lactamase III
0.5
ampicillin
30°C, pH 7.0
0.615
ampicillin
pH 7.5, 25°C, recombinant His-tagged mutant E164A
0.676
ampicillin
pH 7.0, 25°C
1.3
ampicillin
-
30°C, pH 7.5
1.33
ampicillin
mutant D120N, pH 7.0, 25°C
3
ampicillin
pH 7.0, 25°C
0.06
azlocillin
-
-
0.000004
aztreonam
-
30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1
0.00001
aztreonam
-
30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1
0.017
aztreonam
pH 7.0, 30°C
0.027
aztreonam
TEM-149 mutant T182M, pH 7.0, 25°C
0.04
aztreonam
pH and temperature not specified in the publication
0.041
aztreonam
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
0.051
aztreonam
TEM-149 wild-type, pH 7.0, 25°C
0.055
aztreonam
-
wild-type enzyme
0.1
aztreonam
30°C, pH 7.0
0.12
aztreonam
beta-lactamases CTX-M-25
0.13
aztreonam
beta-lactamases CTX-M-26
0.39
aztreonam
-
in 0.01 M phosphate buffer (pH 7.0), at 25°C
0.484
aztreonam
-
at 25°C in 50 mM sodium phosphate (pH 7.0)
0.66
aztreonam
-
mutant enzyme P51L
1.66
aztreonam
-
mutant enzyme S164R
2.5
aztreonam
30°C, pH 7.0
0.00025
benzylpenicillin
30°C, pH 7.0
0.0004
benzylpenicillin
-
30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1
0.0004
benzylpenicillin
-
30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2
0.0005
benzylpenicillin
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.0006
benzylpenicillin
100 microM nitrocefin as the reporter substrate, TEM-149 wild-type, pH 7.0, 25°C
0.0007
benzylpenicillin
100 microM nitrocefin as the reporter substrate, TEM-149 mutant T182M, pH 7.0, 25°C
0.001
benzylpenicillin
-
-
0.001
benzylpenicillin
-
30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1
0.0017
benzylpenicillin
-
at 30°C in 50 mM sodium phosphate buffer (pH 7.0)
0.0017
benzylpenicillin
-
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.002
benzylpenicillin
-
-
0.0021
benzylpenicillin
-
30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1
0.0023
benzylpenicillin
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.0029
benzylpenicillin
-
enzyme 2, BRO-2
0.003
benzylpenicillin
-
enzyme 1, BRO-1
0.009
benzylpenicillin
-
strain 6346/C
0.01
benzylpenicillin
at 30°C
0.01
benzylpenicillin
in 100 mM Tris-H2SO4, 300 mM K2SO4 (pH 7.0), at 30°C
0.01
benzylpenicillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.011
benzylpenicillin
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
0.012
benzylpenicillin
at 30°C in 100 mM sodium phosphate (pH 7)
0.013
benzylpenicillin
in 30 mM sodium cacodylate buffer (pH 6.5) plus 0.05 mM ZnSO4
0.0153
benzylpenicillin
-
-
0.016
benzylpenicillin
-
in 0.01 M phosphate buffer (pH 7.0), at 25°C
0.017
benzylpenicillin
-
-
0.017
benzylpenicillin
-
-
0.017
benzylpenicillin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.019
benzylpenicillin
at 25°C in 100 mM sodium phosphate (pH 7.0)
0.02
benzylpenicillin
30°C, pH 7.0
0.02
benzylpenicillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.023
benzylpenicillin
-
-
0.025
benzylpenicillin
30°C, pH 7.0
0.025
benzylpenicillin
30°C, pH 7.0
0.026
benzylpenicillin
-
-
0.026
benzylpenicillin
-
pH 7.0, 30°C
0.028
benzylpenicillin
-
-
0.033
benzylpenicillin
-
-
0.04
benzylpenicillin
-
pH 7.5, 37°C
0.049
benzylpenicillin
-
strain 749/C
0.055
benzylpenicillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.06
benzylpenicillin
-
-
0.06
benzylpenicillin
beta-lactamases CTX-M-26
0.06
benzylpenicillin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.062
benzylpenicillin
plasmid pQE32Chl17
-
pH 7.0, 22°C, wild-type enzyme
0.063
benzylpenicillin
-
-
0.065
benzylpenicillin
-
-
0.065
benzylpenicillin
30°C, pH 7.0
0.07
benzylpenicillin
-
-
0.07
benzylpenicillin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.074
benzylpenicillin
beta-lactamases CTX-M-25
0.0746
benzylpenicillin
-
-
0.08
benzylpenicillin
wild-type enzyme
0.09
benzylpenicillin
pH 7.5, 30°C
0.1
benzylpenicillin
plasmid pGEM-T-easy
-
mutant enzyme W154F, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.12
benzylpenicillin
-
wild type
0.15
benzylpenicillin
N116H/N220G mutant, 30°C, pH 6.5
0.15
benzylpenicillin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.155
benzylpenicillin
-
-
0.16
benzylpenicillin
-
-
0.18
benzylpenicillin
-
beta-lactamase III
0.18
benzylpenicillin
pH 7.0, 25°C
0.19
benzylpenicillin
-
-
0.21
benzylpenicillin
H118A mutant, 30°C, pH 6.5
0.25
benzylpenicillin
-
-
0.26
benzylpenicillin
30°C, pH 7.0
0.37
benzylpenicillin
at 30°C in 100 mM sodium phosphate buffer, pH 7.0
0.42
benzylpenicillin
plasmid pQE32Chl17
-
pH 7.0, 22°C, mutant enzyme G240H
0.43
benzylpenicillin
-
-
0.55
benzylpenicillin
T157A mutant, 30°C, pH 6.5
0.6
benzylpenicillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.71
benzylpenicillin
30°C, pH 7.0
0.73
benzylpenicillin
V67I mutant, 30°C, pH 6.5
0.74
benzylpenicillin
-
-
0.8
benzylpenicillin
30°C, pH 7.0
0.8
benzylpenicillin
K226Q mutant, 30°C, pH 6.5
0.87
benzylpenicillin
wild-type, 30°C, pH 6.5
0.92
benzylpenicillin
N116H/N220G/K224Q mutant, 30°C, pH 6.5
1
benzylpenicillin
V67A mutant, 30°C, pH 6.5
2.6
benzylpenicillin
mutant enzyme D120A
3.3
benzylpenicillin
-
beta-lactamse II
5
benzylpenicillin
above, H196A mutant, 30°C, pH 6.5
5
benzylpenicillin
above, K224Q mutant, 30°C, pH 6.5
5
benzylpenicillin
above, V67D mutant, 30°C, pH 6.5
8
benzylpenicillin
mutant enzyme D120A, 1 mM Zn(NO3)2 added
0.032
biapenem
wild-type enzyme, pH 7.0, 25°C
0.045
biapenem
mutant D120C, pH 7.0, 25°C
0.066
biapenem
pH 7.0, 25°C
0.081
biapenem
mutant D120S, pH 7.0, 25°C
0.1
biapenem
D120A mutant, 30°C, pH 6.5
0.1
biapenem
N116H/N220G mutant, 30°C, pH 6.5
0.1
biapenem
V67A mutant, 30°C, pH 6.5
0.118
biapenem
30°C, pH 6.5, mutant enzyme N220G
0.128
biapenem
mutant D120N, pH 7.0, 25°C
0.166
biapenem
30°C, pH 6.5, wild-type enzyme
0.17
biapenem
wild-type, 30°C, pH 6.5
0.39
biapenem
N116H/N220G/K224Q mutant, 30°C, pH 6.5
0.73
biapenem
H118A mutant, 30°C, pH 6.5
0.84
biapenem
K226Q mutant, 30°C, pH 6.5
1.5
biapenem
above, H263A mutant, 30°C, pH 6.5
1.5
biapenem
above, K224Q mutant, 30°C, pH 6.5
1.5
biapenem
above, T157A mutant, 30°C, pH 6.5
1.5
biapenem
above, V67D mutant, 30°C, pH 6.5
1.5
biapenem
above, V67I mutant, 30°C, pH 6.5
1.5
biapenem
above, V67LFKHV mutant, 30°C, pH 6.5
36.46
Bocillin-FL
pH 8.0, 30°C, recombinant enzyme Y194F
58.28
Bocillin-FL
pH 8.0, 30°C, recombinant enzyme E193A
0.002
carbenicillin
-
-
0.0037
carbenicillin
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.017
carbenicillin
at 25°C in 100 mM sodium phosphate (pH 7.0)
0.017
carbenicillin
-
in 0.01 M phosphate buffer (pH 7.0), at 25°C
0.02174
carbenicillin
pH 8.0, 30°C, recombinant wild-type enzyme
0.031
carbenicillin
pH 7.0, 25°C
0.068
carbenicillin
pH 7.0, 30°C, wild-type enzyme
0.129
carbenicillin
pH 7.0, 30°C, mutant R234K
0.135
carbenicillin
-
penicillinase I
0.15
carbenicillin
-
penicillinase II
0.17
carbenicillin
25°C, pH 7.0
0.32
carbenicillin
in 30 mM sodium cacodylate buffer (pH 6.5) plus 0.05 mM ZnSO4
1.28
carbenicillin
pH 7.0, 25°C
0.008
cefaclor
-
lactamase ZnZn-L1, 25°C, pH 7.0
0.013
cefaclor
wild-type enzyme, pH 7.0, 25°C
0.034
cefaclor
-
enzyme 1, BRO-1
0.035
cefaclor
-
lactamase ZnFe-L1, 25°C, pH 7.0
0.04
cefaclor
-
lactamase ZnCo-L1, 25°C, pH 7.0
0.043
cefaclor
-
enzyme 2, BRO-2
0.043
cefaclor
-
lactamase CoCo-L1, 25°C, pH 7.0
0.058
cefaclor
-
lactamase Cu-L1, 25°C, pH 7.0
0.08
cefaclor
mutant D120S, pH 7.0, 25°C
0.091
cefaclor
-
lactamase ZnNi-L1, 25°C, pH 7.0
0.098
cefaclor
mutant D120C, pH 7.0, 25°C
0.55
cefaclor
mutant D120N, pH 7.0, 25°C
0.096
cefaloridine
-
-
0.125
cefaloridine
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
0.27
cefaloridine
30°C, pH 7.0
0.8
cefaloridine
30°C, pH 7.0
0.008
cefalothin
-
0.012
cefalothin
30°C, pH 7.0
0.027
cefalothin
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
0.08
cefalothin
30°C, pH 7.0
0.005
cefalotin
pH 7.2, 25°C, recombinant enzyme
0.01
cefalotin
pH 7.2, 25°C, recombinant enzyme
0.011
cefalotin
pH 7.2, 25°C, recombinant enzyme
0.013
cefalotin
pH 7.2, 25°C, recombinant enzyme
0.015
cefalotin
pH 7.2, 25°C, recombinant enzyme
0.029
cefalotin
pH 7.2, 25°C, recombinant enzyme
0.163
cefalotin
R276N mutant, 25°C
0.206
cefalotin
R276W mutant, 25°C
0.207
cefalotin
R276G mutant, 25°C
0.28
cefalotin
R276H mutant, 25°C
0.298
cefalotin
R276C mutant, 25°C
0.35
cefalotin
R276S mutant, 25°C
0.433
cefalotin
CTX-M-1 wild type, 25°C
0.0032
cefamandole
-
beta-lactamase D
0.005
cefamandole
-
beta-lactamase A
0.006
cefamandole
-
beta-lactamase B
0.0065
cefamandole
-
beta-lactamase C
0.184
cefamandole
-
in 100 mM MES (pH 6.4)
0.018
cefazolin
-
beta-lactamase A
0.025
cefazolin
in 30 mM sodium cacodylate buffer (pH 6.5) plus 0.05 mM ZnSO4
0.035
cefazolin
TEM-149 mutant T182M, pH 7.0, 25°C
0.0499
cefazolin
-
beta-lactamase D
0.054
cefazolin
-
30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1
0.068
cefazolin
TEM-149 wild-type, pH 7.0, 25°C
0.08
cefazolin
pH 7.0, 30°C
0.095
cefazolin
plasmid pQE32Chl17
-
pH 7.0, 22°C, mutant enzyme G240H
0.1
cefazolin
-
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.12
cefazolin
pH 7.0, 30°C
0.13
cefazolin
plasmid pQE32Chl17
-
pH 7.0, 22°C, wild-type enzyme
0.15
cefazolin
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.254
cefazolin
-
beta-lactamase B
0.267
cefazolin
-
beta-lactamase C
0.43
cefazolin
-
30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1
0.54
cefazolin
-
at 30°C in 50 mM sodium phosphate buffer (pH 7.0)
1.5
cefazolin
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.0008
cefepime
pH 7.5, 30°C
0.008
cefepime
pH 7.5, 37°C
0.016
cefepime
TEM-149 wild-type, pH 7.0, 25°C
0.026
cefepime
pH 7.0, 30°C
0.027
cefepime
D66A mutant, pH 7.4, room temperature
0.03
cefepime
TEM-149 mutant T182M, pH 7.0, 25°C
0.035
cefepime
D66M mutant, pH 7.4, room temperature
0.049
cefepime
37°C, pH 7.0
0.095
cefepime
30°C, pH 7.0
0.15
cefepime
30°C, pH 7.0
0.15
cefepime
D66N mutant, pH 7.4, room temperature
0.17
cefepime
wild type, pH 7.4, room temperature
0.177
cefepime
pH 7.2, 37°C, recombinant enzyme
0.202
cefepime
pH 7.0, 25°C
0.21
cefepime
D66W mutant, pH 7.4, room temperature
0.23
cefepime
D66Y mutant, pH 7.4, room temperature
0.36
cefepime
pH 7.0, 30°C
0.431
cefepime
25°C, pH 7.0
0.505
cefepime
37°C, pH 7.0
1
cefepime
Km above 1.0 mM at 30°C in 100 mM sodium phosphate (pH 7)
1
cefepime
-
Km above 1.0 mM, in 0.01 M phosphate buffer (pH 7.0), at 25°C
37
cefepime
mutant AmpC-B2-S287N
75
cefepime
mutant AmpC-A-S287N
0.0012
cefoperazone
-
in 0.01 M phosphate buffer (pH 7.0), at 25°C
0.0383
cefoperazone
pH 7.5, 25°C, recombinant His-tagged mutant E162A
0.0574
cefoperazone
pH 7.5, 25°C, recombinant His-tagged wild-type enzyme
0.0962
cefoperazone
pH 7.5, 25°C, recombinant His-tagged mutant E164A
0.14
cefoperazone
-
pH 7.5, 37°C
0.0000009
cefotaxime
pH 7.0, 30°C
0.000015
cefotaxime
-
30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1
0.00002
cefotaxime
30°C, pH 7.0
0.00002
cefotaxime
in 20 mM phosphate buffer, (pH 7.0) at 30°C
0.00007
cefotaxime
-
30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1
0.00009
cefotaxime
in 20 mM phosphate buffer, (pH 7.0) at 30°C
0.0005
cefotaxime
30°C, pH 7.0
0.0005
cefotaxime
in 20 mM phosphate buffer, (pH 7.0) at 30°C
0.001
cefotaxime
30°C, pH 7.0
0.003
cefotaxime
pH 7.5, 30°C
0.004
cefotaxime
25°C, pH 7.0
0.004
cefotaxime
-
30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1
0.0081
cefotaxime
-
pH 7.5, 25°C, strain GCI
0.0081
cefotaxime
-
GC1 beta-lactamase
0.014
cefotaxime
wild type OXA-1, pH 7.4, room temperature
0.0172
cefotaxime
-
pH 7.5, 25°C, strain P99
0.0172
cefotaxime
-
P99 beta-lactamase
0.021
cefotaxime
pH 7.5, 37°C
0.021
cefotaxime
His6-tagged wild type OXA-1, pH 7.4, room temperature
0.022
cefotaxime
pH 7.0, 30°C
0.024
cefotaxime
D66N mutant, pH 7.4, room temperature
0.028
cefotaxime
beta-lactamases CTX-M-25
0.029
cefotaxime
30°C, pH 7.0
0.031
cefotaxime
37°C, pH 7.0
0.032
cefotaxime
TEM-149 mutant T182M, pH 7.0, 25°C
0.036
cefotaxime
D66M mutant, pH 7.4, room temperature
0.036
cefotaxime
wild type, pH 7.4, room temperature
0.04
cefotaxime
-
30°C, pH 7.5
0.041
cefotaxime
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
0.043
cefotaxime
-
in 0.01 M phosphate buffer (pH 7.0), at 25°C
0.043
cefotaxime
TEM-149 wild-type, pH 7.0, 25°C
0.049
cefotaxime
in 30 mM sodium cacodylate buffer (pH 6.5) plus 0.05 mM ZnSO4
0.05
cefotaxime
N116H/N220G mutant, 30°C, pH 6.5
0.057
cefotaxime
D66Y mutant, pH 7.4, room temperature
0.063
cefotaxime
pH not specified in the publication, 30°C, recombinant enzyme
0.07
cefotaxime
D66A mutant, pH 7.4, room temperature
0.086
cefotaxime
pH and temperature not specified in the publication
0.089
cefotaxime
-
at 25°C in 50 mM sodium phosphate (pH 7.0)
0.09
cefotaxime
30°C, pH 7.0
0.1
cefotaxime
above, wild-type, 30°C, pH 6.5
0.1
cefotaxime
mutant AmpC-A-S287N
0.103
cefotaxime
37°C, pH 7.0
0.118
cefotaxime
R276G mutant, 25°C
0.133
cefotaxime
R276H mutant, 25°C
0.14
cefotaxime
K226Q mutant, 30°C, pH 6.5
0.143
cefotaxime
R276S mutant, 25°C
0.15
cefotaxime
30°C, pH 7.0
0.15
cefotaxime
beta-lactamases CTX-M-26
0.153
cefotaxime
R276W mutant, 25°C
0.157
cefotaxime
CTX-M-1 wild type, 25°C
0.163
cefotaxime
R276N mutant, 25°C
0.168
cefotaxime
plasmid pBC
-
pH 7.4, 22°C, T237S mutant enzyme
0.207
cefotaxime
plasmid pBC
-
pH 7.4, 22°C, wild-type enzyme
0.22
cefotaxime
R276C mutant, 25°C
0.25
cefotaxime
30°C, pH 7.0
0.341
cefotaxime
at 30°C in 100 mM sodium phosphate buffer, pH 7.0
0.3647
cefotaxime
pH 8.0, 30°C, recombinant wild-type enzyme
0.434
cefotaxime
N116H/N220G/K224Q mutant, 30°C, pH 6.5
0.45
cefotaxime
T157A mutant, 30°C, pH 6.5
0.62
cefotaxime
plasmid pQE32Chl17
-
pH 7.0, 22°C, mutant enzyme G240H
0.7
cefotaxime
K224Q mutant, 30°C, pH 6.5
0.79
cefotaxime
at 30°C in 100 mM sodium phosphate (pH 7)
0.84
cefotaxime
plasmid pQE32Chl17
-
pH 7.0, 22°C, wild-type enzyme
1
cefotaxime
mutant AmpC-B2-S287N
25
cefotaxime
wild-type AmpC-A
45
cefotaxime
wild-type AmpC-B2
0.015
cefotiam
-
-
0.0000011
cefoxitin
-
30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2
0.00001
cefoxitin
Km less than 0.00001 mM at 30°C in 100 mM sodium phosphate (pH 7)
0.000018
cefoxitin
30°C, pH 7.0
0.000025
cefoxitin
pH 7.0, 30°C
0.000055
cefoxitin
-
30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1
0.0005
cefoxitin
-
30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1
0.00075
cefoxitin
-
30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1
0.001
cefoxitin
30°C, pH 7.0
0.0011
cefoxitin
wild-type enzyme, pH 7.0, 25°C
0.0012
cefoxitin
37°C, pH 7.0
0.01
cefoxitin
-
in 0.01 M phosphate buffer (pH 7.0), at 25°C
0.011
cefoxitin
pH 7.5, 30°C
0.012
cefoxitin
pH 7.5, 37°C
0.016
cefoxitin
pH 7.2, 25°C, recombinant enzyme
0.023
cefoxitin
pH 7.2, 25°C, recombinant enzyme
0.027
cefoxitin
pH 7.2, 25°C, recombinant enzyme
0.043
cefoxitin
pH 7.2, 25°C, recombinant enzyme
0.044
cefoxitin
30°C, pH 7.0
0.05
cefoxitin
pH 7.2, 25°C, recombinant enzyme
0.053
cefoxitin
mutant D120S, pH 7.0, 25°C
0.055
cefoxitin
mutant D120C, pH 7.0, 25°C
0.063
cefoxitin
pH 7.2, 25°C, recombinant enzyme
0.069
cefoxitin
pH 7.2, 25°C
0.077
cefoxitin
-
at 25°C in 50 mM sodium phosphate (pH 7.0)
0.079
cefoxitin
pH 7.2, 37°C, recombinant enzyme
0.098
cefoxitin
mutant D120N, pH 7.0, 25°C
0.099
cefoxitin
pH 7.0, 25°C
0.107
cefoxitin
pH 7.2, 25°C, recombinant enzyme
0.127
cefoxitin
-
in 100 mM MES (pH 6.4)
0.195
cefoxitin
-
at 30°C
0.206
cefoxitin
25°C, pH 7.0
0.65
cefoxitin
at 30°C in 100 mM sodium phosphate buffer, pH 7.0
0.7
cefoxitin
mutant AmpC-A-S287N
0.8
cefoxitin
mutant AmpC-B2-S287N
1
cefoxitin
wild-type AmpC-A
1.5
cefoxitin
wild-type AmpC-B2
0.021
cefpirome
37°C, pH 7.0
0.085
cefpirome
pH 7.0, 30°C
0.136
cefpirome
at 30°C in 100 mM sodium phosphate (pH 7)
0.67
cefpirome
30°C, pH 7.0
0.00012
ceftazidime
pH 7.0, 30°C
0.0009
ceftazidime
30°C, pH 7.0
0.0013
ceftazidime
pH 7.5, 30°C
0.0057
ceftazidime
37°C, pH 7.0
0.009
ceftazidime
30°C, pH 7.0
0.013
ceftazidime
beta-lactamases CTX-M-25
0.015
ceftazidime
pH 7.5, 37°C
0.019
ceftazidime
pH 7.2, 25°C, recombinant enzyme
0.019
ceftazidime
TEM-149 wild-type, pH 7.0, 25°C
0.026
ceftazidime
TEM-149 mutant T182M, pH 7.0, 25°C
0.031
ceftazidime
pH 7.2, 25°C
0.031
ceftazidime
25°C, pH 7.0
0.035
ceftazidime
pH and temperature not specified in the publication
0.037
ceftazidime
pH 7.2, 37°C, recombinant enzyme
0.052
ceftazidime
-
at 25°C in 50 mM sodium phosphate (pH 7.0)
0.059
ceftazidime
-
wild-type enzyme
0.079
ceftazidime
pH 7.2, 25°C, recombinant enzyme
0.08
ceftazidime
-
mutant enzyme P51L
0.086
ceftazidime
pH 7.0, 30°C
0.086
ceftazidime
pH 7.2, 25°C, recombinant enzyme
0.1
ceftazidime
pH 7.2, 25°C, recombinant enzyme
0.115
ceftazidime
pH 7.2, 25°C, recombinant enzyme
0.115
ceftazidime
30°C, pH 7.0. The affinity of MIR-4 beta-lactamase for ceftazidime is quite low
0.133
ceftazidime
pH 7.2, 25°C, recombinant enzyme
0.14
ceftazidime
-
30°C, pH 7.5
0.144
ceftazidime
pH 7.2, 25°C, recombinant enzyme
0.28
ceftazidime
-
in 100 mM MES (pH 6.4)
0.4
ceftazidime
mutant AmpC-A-S287N
0.5
ceftazidime
30°C, pH 7.0
0.593
ceftazidime
-
at 30°C
1
ceftazidime
Km above 1.0 mM at 30°C in 100 mM sodium phosphate (pH 7)
1
ceftazidime
-
Km above 1.0 mM, in 0.01 M phosphate buffer (pH 7.0), at 25°C
1
ceftazidime
mutant AmpC-B2-S287N
3
ceftazidime
30°C, pH 7.0
3.3
ceftazidime
beta-lactamases CTX-M-26
4.7
ceftazidime
30°C, pH 7.0
13
ceftazidime
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
70
ceftazidime
wild-type AmpC-A
270
ceftazidime
wild-type AmpC-B2
0.006
ceftriaxone
pH 7.0, 30°C
0.01176
ceftriaxone
pH 8.0, 30°C, recombinant wild-type enzyme
0.03
ceftriaxone
30°C, pH 7.0
0.52
ceftriaxone
-
in 100 mM MES (pH 6.4)
0.95
ceftriaxone
at 30°C in 100 mM sodium phosphate (pH 7)
0.0000011
cefuroxime
pH 7.0, 30°C
0.0000012
cefuroxime
-
30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2
0.000005
cefuroxime
-
30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1
0.000019
cefuroxime
-
30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1
0.0006
cefuroxime
-
30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1
0.001
cefuroxime
pH 7.5, 37°C
0.001
cefuroxime
30°C, pH 7.0
0.004
cefuroxime
30°C, pH 7.0
0.0056
cefuroxime
-
pH 7.5, 25°C, strain P99
0.0056
cefuroxime
-
P99 beta-lactamase
0.007
cefuroxime
pH 7.5, 30°C
0.007
cefuroxime
25°C, pH 7.0
0.009
cefuroxime
pH 7.2, 25°C
0.011
cefuroxime
pH 7.0, 25°C
0.019
cefuroxime
-
in 0.01 M phosphate buffer (pH 7.0), at 25°C
0.024
cefuroxime
pH and temperature not specified in the publication
0.031
cefuroxime
-
GC1 beta-lactamase
0.034
cefuroxime
pH 7.0, 30°C
0.04
cefuroxime
30°C, pH 7.0
0.04
cefuroxime
30°C, pH 7.0
0.044
cefuroxime
beta-lactamases CTX-M-25
0.05
cefuroxime
-
30°C, pH 7.5
0.056
cefuroxime
-
enzyme 2, BRO-2
0.068
cefuroxime
-
enzyme 1, BRO-1
0.068
cefuroxime
pH 7.2, 37°C, recombinant enzyme
0.08
cefuroxime
30°C, pH 7.0
0.085
cefuroxime
wild-type, pH 7.0, 22°C
0.105
cefuroxime
at 30°C in 100 mM sodium phosphate (pH 7)
0.3
cefuroxime
beta-lactamases CTX-M-26
0.378
cefuroxime
-
beta-lactamase A
5.1
cefuroxime
-
in 100 mM MES (pH 6.4)
0.023
CENTA
at 30°C
0.195
CENTA
-
in 100 mM MES (pH 6.4)
0.0017
cephalexin
-
-
0.008
cephalexin
-
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.0085
cephalexin
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.00897
cephalexin
pH 8.0, 30°C, recombinant wild-type enzyme
0.014
cephalexin
-
30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1
0.016
cephalexin
-
30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1
0.016
cephalexin
-
30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2
0.017
cephalexin
pH 7.0, 30°C
0.03
cephalexin
-
at 30°C in 50 mM sodium phosphate buffer (pH 7.0)
0.042
cephalexin
-
30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1
0.05
cephalexin
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.168
cephalexin
-
pH 7.0, 25°C
1.162
cephalexin
plasmid pBG66
-
pH and temperature not specified in the publication, wild-type enzyme
1.56
cephalexin
plasmid pBG66
-
pH and temperature not specified in the publication, mutant enzyme N170A
2.59
cephalexin
plasmid pBG66
-
pH and temperature not specified in the publication, mutant enzyme N170G
2.86
cephaloglycin
-
-
0.0017
cephaloridine
-
enzyme 1, BRO-1
0.0028
cephaloridine
-
enzyme 2, BRO-2
0.0079
cephaloridine
-
beta-lactamase D
0.008
cephaloridine
wild-type enzyme
0.011
cephaloridine
-
beta-lactamase A
0.0115
cephaloridine
-
beta-lactamase C
0.018
cephaloridine
-
mutant enzyme P51L
0.0194
cephaloridine
-
beta-lactamase B
0.028
cephaloridine
-
wild-type enzyme
0.045
cephaloridine
at 30°C in 100 mM sodium phosphate (pH 7)
0.05
cephaloridine
plasmid pGEM-T-easy
-
mutant enzyme W154F, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.053
cephaloridine
N116H/N220G/K224Q mutant, 30°C, pH 6.5
0.06
cephaloridine
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.065
cephaloridine
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.07
cephaloridine
-
mutant enzyme K104E
0.077
cephaloridine
37°C, pH 7.0
0.08
cephaloridine
-
pH and temperature not specified in the publication
0.08
cephaloridine
-
pH and temperature not specified in the publication, OXA-1 beta-lactamase
0.093
cephaloridine
-
30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1
0.093
cephaloridine
-
30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2
0.0979
cephaloridine
-
wild-type enzyme
0.1
cephaloridine
37°C, pH 7.0
0.108
cephaloridine
-
penicillinase II
0.11
cephaloridine
-
30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1
0.13
cephaloridine
30°C, pH 7.0
0.134
cephaloridine
-
penicillinase I
0.145
cephaloridine
N116H/N220G mutant, 30°C, pH 6.5
0.15
cephaloridine
mutant enzyme D120A, 1 mM Zn(NO3)2 added
0.156
cephaloridine
-
mutant enzyme S164R
0.2
cephaloridine
mutant enzyme D120E
0.2
cephaloridine
mutant enzyme D120E, 1 mM Zn(NO3)2 added
0.27
cephaloridine
mutant enzyme D120A
0.29
cephaloridine
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.4
cephaloridine
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.45
cephaloridine
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.506
cephaloridine
at 30°C in 100 mM sodium phosphate buffer, pH 7.0
0.75
cephaloridine
30°C, pH 7.0
1
cephaloridine
K224Q mutant, 30°C, pH 6.5
1.4
cephaloridine
-
pH 7.5, 37°C
1.7
cephaloridine
K226Q mutant, 30°C, pH 6.5
2
cephaloridine
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
2.5
cephaloridine
30°C, pH 7.0
4.5
cephaloridine
above, H118A mutant, 30°C, pH 6.5
4.5
cephaloridine
above, H196A mutant, 30°C, pH 6.5
6
cephaloridine
wild-type, 30°C, pH 6.5
9.5
cephaloridine
-
beta-lactamase III
60
cephaloridine
mutant AmpC-A-S287N
130
cephaloridine
mutant AmpC-B2-S287N
650
cephaloridine
wild-type AmpC-A
950
cephaloridine
wild-type AmpC-B2
0.003
cephalosporin C
-
enzyme 2, BRO-2
0.0039
cephalosporin C
-
enzyme 1, BRO-1
0.05
cephalosporin C
-
strain 749/C
0.114
cephalosporin C
-
in 100 mM MES (pH 6.4)
1.1
cephalosporin C
-
beta-lactamse II
0.0009
cephalothin
-
enzyme 1, BRO-1
0.0012
cephalothin
-
enzyme 2, BRO-2
0.0021
cephalothin
-
30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1
0.0021
cephalothin
-
30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2
0.004
cephalothin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.0047
cephalothin
-
beta-lactamase D
0.005
cephalothin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.005
cephalothin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.0052
cephalothin
-
beta-lactamase C
0.0062
cephalothin
-
beta-lactamase B
0.0068
cephalothin
-
beta-lactamase A
0.007
cephalothin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.007
cephalothin
pH not specified in the publication, 30°C, recombinant enzyme
0.0089
cephalothin
wild-type enzyme, pH 7.0, 25°C
0.009
cephalothin
wild type, pH 7.4, room temperature
0.01
cephalothin
D66M mutant, pH 7.4, room temperature
0.011
cephalothin
D66N mutant, pH 7.4, room temperature
0.014
cephalothin
plasmid pBC
-
pH 7.4, 22°C, wild-type enzyme
0.015
cephalothin
at 30°C in 100 mM sodium phosphate (pH 7)
0.015
cephalothin
in 100 mM Tris-H2SO4, 300 mM K2SO4 (pH 7.0), at 30°C
0.0154
cephalothin
-
pH 7.5, 25°C, strain P99
0.0154
cephalothin
-
P99 beta-lactamase
0.018
cephalothin
plasmid pBC
-
pH 7.4, 22°C, T237S mutant enzyme
0.021
cephalothin
pH and temperature not specified in the publication
0.022
cephalothin
25°C, pH 7.0
0.023
cephalothin
plasmid pQE32Chl17
-
pH 7.0, 22°C, mutant enzyme G240H
0.025
cephalothin
plasmid pGEM-T-easy
-
mutant enzyme W154F, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.029
cephalothin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
0.03
cephalothin
-
30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1
0.03
cephalothin
plasmid pBC
-
pH 7.4, 22°C, T237A mutant enzyme
0.031
cephalothin
-
pH 7.5, 25°C, strain GCI
0.033
cephalothin
mutant D120C, pH 7.0, 25°C
0.037
cephalothin
D66Y mutant, pH 7.4, room temperature
0.0379
cephalothin
37°C, pH 7.0
0.038
cephalothin
-
30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1
0.04
cephalothin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.045
cephalothin
pH 7.0, 30°C
0.045
cephalothin
pH 7.5, 25°C, recombinant His-tagged wild-type enzyme
0.046
cephalothin
30°C, pH 7.0
0.046
cephalothin
mutant D120S, pH 7.0, 25°C
0.046
cephalothin
-
GC1 beta-lactamase
0.046
cephalothin
in 20 mM phosphate buffer, (pH 7.0) at 30°C
0.047
cephalothin
at 30°C
0.049
cephalothin
-
in 0.01 M phosphate buffer (pH 7.0), at 25°C
0.05
cephalothin
30°C, pH 7.0
0.0554
cephalothin
-
mutant enzyme K232N
0.057
cephalothin
pH 7.5, 25°C, recombinant His-tagged mutant E162A
0.059
cephalothin
D66W mutant, pH 7.4, room temperature
0.062
cephalothin
30°C, pH 7.0
0.07
cephalothin
30°C, pH 7.0
0.083
cephalothin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
0.1
cephalothin
30°C, pH 7.0
0.1
cephalothin
-
mutant enzyme D170N
0.1
cephalothin
D66A mutant, pH 7.4, room temperature
0.106
cephalothin
in 20 mM phosphate buffer, (pH 7.0) at 30°C
0.11
cephalothin
beta-lactamases CTX-M-26
0.117
cephalothin
-
at 30°C
0.12
cephalothin
pH 7.5, 25°C
0.129
cephalothin
-
at 25°C in 50 mM sodium phosphate (pH 7.0)
0.148
cephalothin
30°C, pH 7.0
0.148
cephalothin
in 20 mM phosphate buffer, (pH 7.0) at 30°C
0.15
cephalothin
mutant D120N, pH 7.0, 25°C
0.163
cephalothin
-
wild-type enzyme
0.165
cephalothin
30°C, pH not specified in the publication
0.18
cephalothin
plasmid pQE32Chl17
-
pH 7.0, 22°C, wild-type enzyme
0.182
cephalothin
plasmid pBG66
-
pH and temperature not specified in the publication, wild-type enzyme
0.19
cephalothin
30°C, pH 7.0
0.19
cephalothin
beta-lactamases CTX-M-25
0.195
cephalothin
pH 7.0, 30°C
0.21
cephalothin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.21
cephalothin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.227
cephalothin
pH 7.5, 25°C, recombinant His-tagged mutant E164A
0.28
cephalothin
30°C, pH 7.0
0.3
cephalothin
-
penicillinase I
0.356
cephalothin
-
penicillinase II
0.45
cephalothin
-
pH 7.5, 37°C
0.45
cephalothin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.577
cephalothin
at 30°C in 100 mM sodium phosphate buffer, pH 7.0
0.655
cephalothin
pH 8.0, 30°C, recombinant wild-type enzyme
1.5
cephalothin
plasmid pBG66
-
pH and temperature not specified in the publication, mutant enzyme N170G
5.5
cephalothin
mutant AmpC-A-S287N
30
cephalothin
wild-type AmpC-A
45
cephalothin
mutant AmpC-B2-S287N
85
cephalothin
wild-type AmpC-B2
106
cephalothin
30°C, pH 7.0
0.0001
cephalotin
pH 7.5, 30°C
0.01
cephalotin
pH 7.0, 30°C
0.014
cephalotin
pH 7.0, 25°C
0.031
cephalotin
pH 7.5, 37°C
0.152
cephalotin
-
in 100 mM MES (pH 6.4)
0.26
cephalotin
-
pH 7.0, 30°C
0.9
cephalotin
30°C, pH 7.0
0.0052
cephapirin
-
beta-lactamase A
0.0122
cephapirin
-
beta-lactamase D
0.0472
cephapirin
-
beta-lactamase C
0.0795
cephapirin
-
beta-lactamase B
0.015
cephradine
-
-
0.0000005
Cloxacillin
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.00016
Cloxacillin
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.0014
Cloxacillin
-
enzyme 1, BRO-1
0.0015
Cloxacillin
-
enzyme 2, BRO-2
0.0287
Cloxacillin
-
wild-type enzyme
0.03
Cloxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.1
Cloxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.11
Cloxacillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.129
Cloxacillin
37°C, pH 7.0
0.14
Cloxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154F, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.166
Cloxacillin
-
mutant enzyme D170N
0.18
Cloxacillin
-
mutant enzyme K232N
0.19
Cloxacillin
30°C, pH 7.0
0.2
Cloxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.22
Cloxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.25
Cloxacillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.27
Cloxacillin
-
pH 7, 20°C
0.0002
doripenem
pH 6.5, 22°C, recombinant enzyme
0.007
doripenem
pH not specified in the publication, 30°C, recombinant enzyme
0.064
doripenem
pH 7.2, 25°C, recombinant enzyme
0.083
doripenem
pH 7.2, 25°C, recombinant enzyme
0.119
doripenem
pH 7.2, 25°C, recombinant enzyme
0.119
doripenem
pH 7.2, 25°C, recombinant enzyme
0.125
doripenem
pH 7.2, 25°C, recombinant enzyme
0.126
doripenem
pH 7.2, 25°C, recombinant enzyme
0.15
doripenem
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
0.151
doripenem
pH 7.2, 25°C, recombinant enzyme
0.0002
ertapenem
pH 6.5, 22°C, recombinant enzyme
0.0008
ertapenem
pH 7.5, 37°C
0.0026
ertapenem
pH 7.5, 30°C
0.004
ertapenem
pH not specified in the publication, 30°C, recombinant enzyme
0.017
ertapenem
pH 7.2, 37°C, recombinant enzyme, in presence of NaCl
0.031
ertapenem
pH 7.2, 25°C
0.073
ertapenem
pH 7.2, 37°C, recombinant enzyme
0.1
ertapenem
pH 7.0, 30°C
0.013
faropenem
pH 7.0, 30°C
0.00005
Imipenem
-
30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1
0.00015
Imipenem
-
30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1
0.00037
Imipenem
-
30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1
0.001
Imipenem
in 20 mM phosphate buffer, (pH 7.0) at 30°C
0.0019
Imipenem
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
0.002
Imipenem
30°C, pH 7.0
0.002
Imipenem
in 20 mM phosphate buffer, (pH 7.0) at 30°C
0.002
Imipenem
-
lactamase ZnZn-L1, 25°C, pH 7.0
0.003
Imipenem
pH 7.0, 25°C
0.0034
Imipenem
-
in 0.01 M phosphate buffer (pH 7.0), at 25°C
0.004
Imipenem
30°C, pH 7.0
0.004
Imipenem
in 20 mM phosphate buffer, (pH 7.0) at 30°C
0.0042
Imipenem
at 30°C in 100 mM sodium phosphate buffer, pH 7.0
0.007
Imipenem
pH 7.5, 30°C
0.0094
Imipenem
-
in 100 mM MES (pH 6.4)
0.011
Imipenem
37°C, pH 7.0
0.013
Imipenem
pH 7.0, 30°C
0.013
Imipenem
-
lactamase CoCo-L1, 25°C, pH 7.0
0.019
Imipenem
plasmid pBC
-
pH 7.4, 22°C, wild-type enzyme
0.02
Imipenem
30°C, pH 7.0
0.02
Imipenem
30°C, pH 7.0
0.02
Imipenem
pH 7.2, 25°C, recombinant enzyme
0.021
Imipenem
plasmid pBC
-
pH 7.4, 22°C, T237S mutant enzyme
0.023
Imipenem
-
lactamase ZnCo-L1, 25°C, pH 7.0
0.027
Imipenem
-
lactamase ZnFe-L1, 25°C, pH 7.0
0.03
Imipenem
30°C, pH not specified in the publication
0.031
Imipenem
plasmid pBC
-
pH 7.4, 22°C, T237A mutant enzyme
0.035
Imipenem
at 30°C in 100 mM sodium phosphate (pH 7)
0.042
Imipenem
-
lactamase Cu-L1, 25°C, pH 7.0
0.045
Imipenem
wild-type enzyme
0.049
Imipenem
pH 7.5, 37°C
0.05
Imipenem
30°C, pH 6.5, mutant enzyme N220G
0.052
Imipenem
pH not specified in the publication, 30°C, recombinant enzyme
0.056
Imipenem
pH 7.2, 25°C, recombinant enzyme
0.057
Imipenem
wild-type enzyme, pH 7.0, 25°C
0.06
Imipenem
30°C, pH 7.0
0.061
Imipenem
-
lactamase ZnNi-L1, 25°C, pH 7.0
0.062
Imipenem
pH 7.2, 25°C, recombinant enzyme
0.063
Imipenem
wild type enzyme, at pH 9.0
0.065
Imipenem
mutant D120C, pH 7.0, 25°C
0.078
Imipenem
pH 7.2, 25°C, recombinant enzyme
0.0792
Imipenem
pH 7.0, 25°C
0.08
Imipenem
-
30°C, pH 7.5
0.082
Imipenem
-
at 25°C in 50 mM sodium phosphate (pH 7.0)
0.082
Imipenem
pH 7.2, 25°C, recombinant enzyme
0.083
Imipenem
wild type enzyme, at pH 8.0
0.094
Imipenem
mutant D120S, pH 7.0, 25°C
0.104
Imipenem
spin-labeled enzyme, pH 7.0, 25°C
0.106
Imipenem
E152C mutant, pH 7.0, 25°C
0.12
Imipenem
wild type enzyme, at pH 7.0
0.148
Imipenem
pH 7.2, 25°C, recombinant enzyme
0.18
Imipenem
V67I mutant, 30°C, pH 6.5
0.185
Imipenem
N116H/N220G mutant, 30°C, pH 6.5
0.2
Imipenem
pH 7.2, 25°C
0.2
Imipenem
mutant AmpC-A-S287N
0.21
Imipenem
D120T mutant, 30°C, pH 6.5
0.22
Imipenem
V67A mutant, 30°C, pH 6.5
0.287
Imipenem
25°C, pH 7.0
0.3
Imipenem
in 30 mM sodium cacodylate buffer (pH 6.5) plus 0.05 mM ZnSO4
0.3
Imipenem
N116H/N220G/K224Q mutant, 30°C, pH 6.5
0.31
Imipenem
mutant D120N, pH 7.0, 25°C
0.31
Imipenem
V67D mutant, 30°C, pH 6.5
0.33
Imipenem
D120A mutant, 30°C, pH 6.5
0.34
Imipenem
30°C, pH 6.5, wild-type enzyme
0.34
Imipenem
wild-type, 30°C, pH 6.5
0.38
Imipenem
K226Q mutant, 30°C, pH 6.5
0.57
Imipenem
T157A mutant, 30°C, pH 6.5
0.64
Imipenem
mutant enzyme D120A
0.75
Imipenem
mutant enzyme D120E
0.933
Imipenem
pH 7.2, 37°C, recombinant enzyme
1.15
Imipenem
H118A mutant, 30°C, pH 6.5
1.5
Imipenem
above, K224Q mutant, 30°C, pH 6.5
1.5
Imipenem
above, V67LFKHV mutant, 30°C, pH 6.5
1.7
Imipenem
H263A mutant, 30°C, pH 6.5
1.8
Imipenem
30°C, pH 7.0
2
Imipenem
Km above 2 mM, in 100 mM Tris-H2SO4, 300 mM K2SO4 (pH 7.0), at 30°C
2
Imipenem
mutant AmpC-B2-S287N
2.5
Imipenem
30°C, pH 7.0
3.1
Imipenem
mutant enzyme D120A, 1 mM Zn(NO3)2 added
3.6
Imipenem
30°C, pH 7.0
4.3
Imipenem
H196A mutant, 30°C, pH 6.5
10
Imipenem
wild-type AmpC-A
32
Imipenem
wild-type AmpC-B2
0.038
Loracarbef
-
enzyme 2, BRO-2
0.05
Loracarbef
-
enzyme 1, BRO-1
0.04
mecillinam
-
enzyme 1, BRO-1
0.063
mecillinam
-
enzyme 2, BRO-2
0.00003
meropenem
30°C, pH not specified in the publication
0.00011
meropenem
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
0.00084
meropenem
pH 7.5, 30°C
0.0034
meropenem
-
in 100 mM MES (pH 6.4)
0.0034
meropenem
pH 6.5, 22°C, recombinant enzyme
0.008
meropenem
pH 7.0, 25°C
0.01
meropenem
pH 7.5, 37°C
0.011
meropenem
pH 7.0, 30°C
0.015
meropenem
wild-type enzyme, pH 7.0, 25°C
0.016
meropenem
pH not specified in the publication, 30°C, recombinant enzyme
0.025
meropenem
25°C, pH 7.0
0.026
meropenem
-
at 25°C in 50 mM sodium phosphate (pH 7.0)
0.04
meropenem
-
30°C, pH 7.5
0.043
meropenem
30°C, pH 7.0
0.045
meropenem
pH 7.2, 25°C, recombinant enzyme
0.049
meropenem
pH 7.2, 25°C, recombinant enzyme
0.054
meropenem
pH 7.2, 25°C, recombinant enzyme
0.057
meropenem
pH 7.2, 25°C, recombinant enzyme
0.058
meropenem
pH 7.2, 25°C, recombinant enzyme
0.06
meropenem
mutant D120C, pH 7.0, 25°C
0.07
meropenem
mutant D120N, pH 7.0, 25°C
0.075
meropenem
pH 7.2, 25°C
0.097
meropenem
mutant D120S, pH 7.0, 25°C
0.099
meropenem
pH 7.2, 25°C, recombinant enzyme
0.119
meropenem
pH 7.2, 25°C, recombinant enzyme
0.142
meropenem
pH 7.2, 37°C, recombinant enzyme
0.215
meropenem
pH 7.0, 25°C
0.279
meropenem
-
at 30°C
0.28
meropenem
in 30 mM sodium cacodylate buffer (pH 6.5) plus 0.05 mM ZnSO4
0.5
meropenem
30°C, pH 7.0
2.5
meropenem
30°C, pH 7.0
4.5
meropenem
30°C, pH 7.0
0.00023
Methicillin
-
strain 6346/C
0.00093
Methicillin
-
strain 749/C
0.026
Methicillin
-
enzyme 2, BRO-2
0.034
Methicillin
-
enzyme 1, BRO-1
2
Methicillin
-
beta-lactamase III
0.005
moxalactam
-
-
0.091
moxalactam
pH 7.0, 25°C
1.035
moxalactam
25°C, pH 7.0
2.4
moxalactam
30°C, pH 7.0
0.0012
nitrocefin
mutant enzyme D120E
0.0013
nitrocefin
mutant enzyme D120A
0.0023
nitrocefin
lactamase ZnCo-L1, 1.0 Zn(2+), 1.0 Co(2+)
0.0036
nitrocefin
lactamase ZnFe-L1, 1.0 Zn(2+), 1.0 Fe(3+)
0.004
nitrocefin
pH 7.2, 25°C, recombinant enzyme
0.004
nitrocefin
lactamase ZnFe-L1, 1.2 Zn(2+), 0.9 Fe(3+)
0.004
nitrocefin
N116H/N220G mutant, 30°C, pH 6.5
0.004
nitrocefin
wild-typewith 1.90 equiv of Zn(2+)
0.0041
nitrocefin
wild-type enzyme, pH 7.0, 25°C
0.0043
nitrocefin
lactamase 1Co-L1, 0.9 Co(2+), 0.10 Zn(2+)
0.005
nitrocefin
pH 7.0, 30°C
0.005
nitrocefin
pH 7.2, 25°C, recombinant enzyme
0.005
nitrocefin
plasmid pBC
-
pH 7.4, 22°C, T237S mutant enzyme
0.0055
nitrocefin
lactamase 1Zn-L1, 1.0 Zn(2+)
0.0059
nitrocefin
-
beta-lactamase D
0.0059
nitrocefin
lactamase ZnZn-L1, 2.0 Zn(2+) added
0.006
nitrocefin
pH 7.2, 37°C, recombinant enzyme
0.006
nitrocefin
pH 7.2, 25°C, recombinant enzyme
0.006
nitrocefin
plasmid pBC
-
pH 7.4, 22°C, wild-type enzyme
0.0064
nitrocefin
-
beta-lactamase A
0.0069
nitrocefin
-
enzyme 1, BRO-1
0.0076
nitrocefin
pH 7.5, 25°C
0.008
nitrocefin
-
30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1
0.008
nitrocefin
-
30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2
0.008
nitrocefin
in 30 mM sodium cacodylate buffer (pH 6.5) plus 0.05 mM ZnSO4
0.008
nitrocefin
pH 7.2, 25°C, recombinant enzyme
0.0083
nitrocefin
pH 7.2, temperature not specified in the publication, recombinant enzyme
0.009
nitrocefin
pH 7.5, 30°C
0.009
nitrocefin
-
pH and temperature not specified in the publication
0.009
nitrocefin
-
pH and temperature not specified in the publication, OXA-1 beta-lactamase
0.00948
nitrocefin
pH 8.0, 30°C, recombinant wild-type enzyme
0.01
nitrocefin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.01
nitrocefin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.011
nitrocefin
-
enzyme 2, BRO-2
0.011
nitrocefin
pH 7.2, 25°C, recombinant enzyme
0.012
nitrocefin
25°C, pH 7.0
0.013
nitrocefin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.0132
nitrocefin
-
mutant enzyme K232N
0.0148
nitrocefin
37°C, pH 7.0
0.015
nitrocefin
-
30°C, pH 8.0
0.015
nitrocefin
H196A mutant, 30°C, pH 6.5
0.015
nitrocefin
H263A mutant, 30°C, pH 6.5
0.015
nitrocefin
plasmid pBC
-
pH 7.4, 22°C, T237A mutant enzyme
0.0157
nitrocefin
-
beta-lactamase B
0.018
nitrocefin
H116C, not applicable Zn(2+) content
0.02
nitrocefin
-
wild-type enzyme
0.02
nitrocefin
wild-type enzyme
0.02
nitrocefin
H116C with 0.85 equiv of Zn(2+)
0.02
nitrocefin
lactamase CoCo-L1, 1.80 Co(2+)
0.02
nitrocefin
TEM-149 wild-type, pH 7.0, 25°C
0.0204
nitrocefin
-
beta-lactamase C
0.021
nitrocefin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
0.022
nitrocefin
pH 7.0, 25°C
0.022
nitrocefin
-
30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1
0.0226
nitrocefin
pH 7.5, 25°C
0.023
nitrocefin
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.025
nitrocefin
30°C, pH 7.0
0.025
nitrocefin
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
0.025
nitrocefin
TEM-149 mutant T182M, pH 7.0, 25°C
0.025
nitrocefin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.026
nitrocefin
D120A mutant, 30°C, pH 6.5
0.026
nitrocefin
V67A mutant, 30°C, pH 6.5
0.027
nitrocefin
mutant enzyme D120A, 1 mM Zn(NO3)2 added
0.028
nitrocefin
pH 7.5, 25°C
0.028
nitrocefin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
0.028
nitrocefin
pH 7.2, temperature not specified in the publication, recombinant enzyme
0.03
nitrocefin
H118A mutant, 30°C, pH 6.5
0.032
nitrocefin
N116H/N220G/K224Q mutant, 30°C, pH 6.5
0.035
nitrocefin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.036
nitrocefin
V67D mutant, 30°C, pH 6.5
0.038
nitrocefin
pH 7.5, 25°C, recombinant His-tagged mutant E162A
0.04
nitrocefin
-
at 30°C in 50 mM sodium phosphate buffer (pH 7.0)
0.041
nitrocefin
-
wild type
0.041
nitrocefin
-
mutant enzyme K104E
0.045
nitrocefin
pH 7.5, 25°C, recombinant His-tagged wild-type enzyme
0.047
nitrocefin
-
in 0.01 M phosphate buffer (pH 7.0), at 25°C
0.05
nitrocefin
-
pH 7.5, 37°C
0.05
nitrocefin
mutant enzyme D120E, 1 mM Zn(NO3)2 added
0.05
nitrocefin
D120T mutant, 30°C, pH 6.5
0.05
nitrocefin
V67I mutant, 30°C, pH 6.5
0.05
nitrocefin
plasmid pGEM-T-easy
-
mutant enzyme W154F, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.0504
nitrocefin
-
mutant enzyme D170N
0.051
nitrocefin
-
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.053
nitrocefin
lactamase 1Fe-L1, 0.9 Co(2+), 0.20 Zn(2+)
0.057
nitrocefin
-
in 100 mM MES (pH 6.4)
0.06
nitrocefin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.065
nitrocefin
-
mutant enzyme S164R
0.068
nitrocefin
mutant D120N, pH 7.0, 25°C
0.069
nitrocefin
mutant D120C, pH 7.0, 25°C
0.072
nitrocefin
H121C with 0.98 equiv of Zn(2+)
0.086
nitrocefin
pH 7.5, 25°C
0.099
nitrocefin
H121C, not applicable Zn(2+) content
0.1
nitrocefin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.103
nitrocefin
mutant D120S, pH 7.0, 25°C
0.106
nitrocefin
pH 7.0, 25°C
0.11
nitrocefin
T157A mutant, 30°C, pH 6.5
0.11
nitrocefin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.116
nitrocefin
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.12
nitrocefin
pH 7.0, 30°C
0.13
nitrocefin
30°C, pH 7.0
0.135
nitrocefin
K224Q mutant, 30°C, pH 6.5
0.179
nitrocefin
-
wild-type enzyme
0.18
nitrocefin
-
mutant enzyme P51L
0.1893
nitrocefin
pH 7.5, 25°C, recombinant His-tagged mutant E164A
0.2
nitrocefin
30°C, pH 7.0
0.224
nitrocefin
-
lactamase Cu-L1, 25°C, pH 7.0
0.23
nitrocefin
-
30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1
0.85
nitrocefin
K226Q mutant, 30°C, pH 6.5
1.3
nitrocefin
wild-type, 30°C, pH 6.5
2
nitrocefin
above, V67LFKHV mutant, 30°C, pH 6.5
16
nitrocefin
-
lactamase NiZn-L1, 25°C, pH 7.0
18
nitrocefin
-
lactamase Ni-L1, 25°C, pH 7.0
0.0000006
Oxacillin
-
30°C, pH 7.0, plasmid-encoded, pBC4e, beta-lactamase CMY-2
0.000003
Oxacillin
30°C, pH 7.0
0.00002
Oxacillin
-
30°C, pH 7.0, plasmid-encoded, pBC3e, beta-lactamase CMY-1
0.00009
Oxacillin
-
30°C, pH 7.0, plasmid-encoded, pBC1e, beta-lactamase ACT-1
0.0001
Oxacillin
-
30°C, pH 7.0, plasmid-encoded, pBC2e, beta-lactamase MIR-1
0.000118
Oxacillin
at 30°C in 50mM sodium phosphate buffer (pH 7.0)
0.02
Oxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.031
Oxacillin
-
pH and temperature not specified in the publication
0.031
Oxacillin
-
pH and temperature not specified in the publication, OXA-1 beta-lactamase
0.0372
Oxacillin
-
mutant enzyme D170N
0.0407
Oxacillin
-
wild-type enzyme
0.06
Oxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154A, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.095
Oxacillin
pH 7.0, 30°C
0.1
Oxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.1
Oxacillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.115
Oxacillin
at 25°C in 100 mM sodium phosphate (pH 7.0)
0.125
Oxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154F, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.13
Oxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 50 mM sodium bicarbonate
0.19
Oxacillin
-
penicillinase I
0.1931
Oxacillin
pH 8.0, 30°C, recombinant wild-type enzyme
0.194
Oxacillin
-
mutant enzyme K232N
0.2
Oxacillin
-
penicillinase II
0.2
Oxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154G, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.2
Oxacillin
plasmid pGEM-T-easy
-
wild-type, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
0.39
Oxacillin
30°C, pH 7.0
0.531
Oxacillin
37°C, pH 7.0
0.65
Oxacillin
plasmid pGEM-T-easy
-
mutant enzyme W154H, 25°C, pH 7, in presence of 1.1 mM sodium bicarbonate
1.85
Oxacillin
30°C, pH not specified in the publication
3.7
Oxacillin
30°C, pH 7.0
0.014
panipenem
pH 7.0, 30°C
0.102
panipenem
pH not specified in the publication, 30°C, recombinant enzyme
0.046
penicillin
25°C, pH 7.0
0.0017
penicillin G
-
mutant enzyme K104E
0.002
penicillin G
pH 7.0, 30°C
0.003
penicillin G
plasmid pBG66
-
pH and temperature not specified in the publication, mutant enzyme N170G
0.00335
penicillin G
pH 8.0, 30°C, recombinant wild-type enzyme
0.0079
penicillin G
mutant E166C, carrying 6-bromoacetyl-2-dimethylaminonaphthalene label, pH 7.0, 22°C
0.008
penicillin G
pH and temperature not specified in the publication
0.008
penicillin G
plasmid pBG66
-
pH and temperature not specified in the publication, mutant enzyme N170A
0.009
penicillin G
-
wild-type enzyme
0.015
penicillin G
-
mutant enzyme S164R
0.019
penicillin G
-
in 100 mM MES (pH 6.4)
0.02
penicillin G
plasmid pBG66
-
pH and temperature not specified in the publication, mutant enzyme N166A/N170G
0.022
penicillin G
30°C, pH 7.0
0.028
penicillin G
plasmid pBG66
-
pH and temperature not specified in the publication, wild-type enzyme
0.0295
penicillin G
-
wild-type enzyme
0.036
penicillin G
-
lactamase CoCo-L1, 25°C, pH 7.0
0.038
penicillin G
wild-type enzyme, pH 7.0, 25°C
0.0386
penicillin G
-
beta-lactamase B
0.041
penicillin G
-
penicillinase II
0.0466
penicillin G
-
mutant enzyme K232N
0.048
penicillin G
wild-type, pH 7.0, 22°C
0.05
penicillin G
-
mutant R61H/E64H/43H, 25°C, pH not specified in the publication
0.0511
penicillin G
-
beta-lactamase A
0.0559
penicillin G
-
beta-lactamase C
0.0563
penicillin G
-
mutant enzyme D170N
0.0568
penicillin G
-
mutant M182T/T195S/A224V, 25°C, pH not specified in the publication
0.057
penicillin G
pH 7.0, 30°C, wild-type enzyme
0.072
penicillin G
mutant E166C, pH 7.0, 22°C
0.1
penicillin G
pH 7.0, 30°C, mutant R234K
0.105
penicillin G
-
penicillinase I
0.1126
penicillin G
-
beta-lactamase D
0.136
penicillin G
-
wild-type, 25°C, pH not specified in the publication
0.218
penicillin G
-
lactamase ZnCo-L1, 25°C, pH 7.0
0.278
penicillin G
-
lactamase ZnZn-L1, 25°C, pH 7.0
0.384
penicillin G
mutant D120N, pH 7.0, 25°C
0.575
penicillin G
-
mutant enzyme P51L
0.776
penicillin G
-
pH 7.0, 25°C
1.127
penicillin G
VIM-13
0.003
phenoxymethylpenicillin
-
-
0.1
phenoxymethylpenicillin
-
wild type
0.00017
piperacillin
30°C, pH 7.0
0.0002
piperacillin
pH 7.0, 30°C
0.001
piperacillin
in 100 mM Tris-H2SO4, 300 mM K2SO4 (pH 7.0), at 30°C
0.0014
piperacillin
100 microM nitrocefin as the reporter substrate, TEM-149 wild-type, pH 7.0, 25°C
0.003
piperacillin
pH 7.0, 30°C
0.0034
piperacillin
100 microM nitrocefin as the reporter substrate, TEM-149 mutant T182M, pH 7.0, 25°C
0.0058
piperacillin
-
enzyme 2, BRO-2
0.006
piperacillin
plasmid pBC
-
pH 7.4, 22°C, T237S mutant enzyme
0.0063
piperacillin
-
enzyme 1, BRO-1
0.007
piperacillin
pH and temperature not specified in the publication
0.00948
piperacillin
-
mutant enzyme K232N
0.01
piperacillin
30°C, pH 7.0
0.011
piperacillin
-
in 0.01 M phosphate buffer (pH 7.0), at 25°C
0.012
piperacillin
plasmid pBC
-
pH 7.4, 22°C, T237A mutant enzyme
0.01256
piperacillin
pH 8.0, 30°C, recombinant wild-type enzyme
0.015
piperacillin
30°C, pH 7.0
0.015
piperacillin
plasmid pBC
-
pH 7.4, 22°C, wild-type enzyme
0.02
piperacillin
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
0.021
piperacillin
at 30°C in 100 mM sodium phosphate (pH 7)
0.0213
piperacillin
-
wild-type enzyme
0.0221
piperacillin
-
mutant enzyme D170N
0.029
piperacillin
30°C, pH not specified in the publication
0.033
piperacillin
at 25°C in 100 mM sodium phosphate (pH 7.0)
0.038
piperacillin
-
at 25°C in 50 mM sodium phosphate (pH 7.0)
0.053
piperacillin
pH not specified in the publication, 30°C, recombinant enzyme
0.0557
piperacillin
pH 7.5, 25°C, recombinant His-tagged mutant E162A
0.058
piperacillin
pH 7.5, 25°C, recombinant His-tagged wild-type enzyme
0.059
piperacillin
-
in 100 mM MES (pH 6.4)
0.069
piperacillin
25°C, pH 7.0
0.0716
piperacillin
pH 7.5, 25°C, recombinant His-tagged mutant E164A
0.072
piperacillin
pH 7.2, 25°C
0.077
piperacillin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
0.105
piperacillin
-
pH 7.4, 22°C, wild-type enzyme SHV-1
0.11
piperacillin
30°C, pH 7.0
0.15
piperacillin
pH 7.5, 37°C
0.17
piperacillin
30°C, pH 7.0
0.375
piperacillin
in 30 mM sodium cacodylate buffer (pH 6.5) plus 0.05 mM ZnSO4
0.454
piperacillin
at 30°C in 100 mM sodium phosphate buffer, pH 7.0
0.5
piperacillin
-
30°C, pH 7.5
0.729
piperacillin
VIM-13
4
piperacillin
30°C, pH 7.0
0.00047
Sulbactam
-
in 50 mM phosphate buffer (pH 7.0), at 30°C
1.3
Sulbactam
in 30 mM sodium cacodylate buffer (pH 6.5) plus 0.05 mM ZnSO4
0.006
ticarcillin
-
0.006
ticarcillin
at 30°C in 100 mM sodium phosphate (pH 7)
0.00792
ticarcillin
pH 8.0, 30°C, recombinant wild-type enzyme
0.008
ticarcillin
30°C, pH 7.0
0.014
ticarcillin
pH and temperature not specified in the publication
0.02
ticarcillin
30°C, pH 7.0
0.04
ticarcillin
in 100 mM Tris-H2SO4, 300 mM K2SO4 (pH 7.0), at 30°C
0.057
ticarcillin
25°C, pH 7.0
0.06
ticarcillin
30°C, pH 7.0
0.115
ticarcillin
30°C, pH 7.0
0.13
ticarcillin
pH 7.5, 37°C
0.18
ticarcillin
pH 7.5, 30°C
0.343
ticarcillin
30°C, pH not specified in the publication
0.5
ticarcillin
pH not specified in the publication, 30°C, recombinant enzyme
2.8
ticarcillin
30°C, pH 7.0
additional information
cefepime
above 0.2
additional information
cefepime
-
above 0.2
additional information
ertapenem
above 0.6
additional information
ertapenem
-
above 0.6
additional information
additional information
kinetics
-
additional information
additional information
kinetics
-
additional information
additional information
steady-state kinetics
-
additional information
additional information
steady-state kinetics
-
additional information
additional information
steady-state kinetics
-
additional information
additional information
-
steady-state kinetics
-
additional information
additional information
-
combination of detailed post- and pre-steady state kinetics
-
additional information
additional information
-
enzyme-ligand interaction kinetics and energies
-
additional information
additional information
Michaelis-Menten kinetics
-
additional information
additional information
-
Michaelis-Menten kinetics
-
additional information
additional information
for substrate cefepime, wild-type AmpC-B2 and AmpC-A, Km-value is above 1000 mM
-
additional information
additional information
-
for substrate cefepime, wild-type AmpC-B2 and AmpC-A, Km-value is above 1000 mM
-
additional information
additional information
pre-steady-state and steady-state kinetics, overview
-
additional information
additional information
pre-steady-state, stopped-flow experiments with cefoxitin, solvent kinetic isotope effects and kinetic analysis with different substrates, kinetic mechanism, overview
-
additional information
additional information
-
pre-steady-state, stopped-flow experiments with cefoxitin, solvent kinetic isotope effects and kinetic analysis with different substrates, kinetic mechanism, overview
-
additional information
additional information
enzyme kinetics and thermodynamics
-
additional information
additional information
Michaelis-Menten steady-state kinetics studies
-
additional information
additional information
-
Michaelis-Menten steady-state kinetics studies
-