Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.5.2.6 extracted from

  • Gacar, G.G.; Midilli, K.; Kolayli, F.; Ergen, K.; Gundes, S.; Hosoglu, S.; Karadenizli, A.; Vahaboglu, H.
    Genetic and enzymatic properties of metallo-beta-lactamase VIM-5 from a clinical isolate of Enterobacter cloacae (2005), Antimicrob. Agents Chemother., 49, 4400-4403.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
EDTA 0.02 mM, 50% inhibition Enterobacter cloacae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.012
-
Imipenem
-
Enterobacter cloacae
0.049
-
meropenem
-
Enterobacter cloacae
0.076
-
cefepime
-
Enterobacter cloacae
0.101
-
cefotaxime
-
Enterobacter cloacae
0.113
-
penicillin
-
Enterobacter cloacae
0.125
-
ampicillin
-
Enterobacter cloacae
0.149
-
ceftazidime
-
Enterobacter cloacae
1.753
-
piperacillin
-
Enterobacter cloacae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
28000
-
x * 28000, SDS-PAGE Enterobacter cloacae

Organism

Organism UniProt Comment Textmining
Enterobacter cloacae Q4ZE97
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Enterobacter cloacae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
26
-
-
Enterobacter cloacae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a penicillin + H2O
-
Enterobacter cloacae a penicilloic acid
-
?
ampicillin + H2O
-
Enterobacter cloacae (2R,4S)-2-[(R)-[[(2R)-2-amino-2-phenylacetyl]amino](carboxy)methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?
cefepime + H2O
-
Enterobacter cloacae (2R)-2-[(R)-[[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-5-[(1-methylpyrrolidinium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
cefotaxime + H2O
-
Enterobacter cloacae (2R)-5-[(acetyloxy)methyl]-2-[(R)-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino](carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid
-
?
ceftazidime + H2O
-
Enterobacter cloacae (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}(carboxy)methyl]-5-[(pyridin-1-ium-1-yl)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylate
-
?
imipenem + H2O
-
Enterobacter cloacae (5R)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-({2-[(iminomethyl)amino]ethyl}sulfanyl)-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?
meropenem + H2O
-
Enterobacter cloacae (4R,5S)-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-4-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid
-
?
penicillin + H2O
-
Enterobacter cloacae ?
-
?
piperacillin + H2O
-
Enterobacter cloacae (2R,4S)-2-[(R)-carboxy[[(2R)-2-[[(4-ethyl-2,3-dioxopiperazin-1-yl)carbonyl]amino]-2-phenylacetyl]amino]methyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid
-
?

Subunits

Subunits Comment Organism
? x * 28000, SDS-PAGE Enterobacter cloacae

Synonyms

Synonyms Comment Organism
metallo-beta-lactamase
-
Enterobacter cloacae
VIM-5
-
Enterobacter cloacae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.1
-
cefepime
-
Enterobacter cloacae
0.2
-
ceftazidime
-
Enterobacter cloacae
2.4
-
meropenem
-
Enterobacter cloacae
3.5
-
Imipenem
-
Enterobacter cloacae
9.2
-
cefotaxime
-
Enterobacter cloacae
14
-
ampicillin
-
Enterobacter cloacae
29
-
penicillin
-
Enterobacter cloacae
47
-
piperacillin
-
Enterobacter cloacae

pI Value

Organism Comment pI Value Maximum pI Value
Enterobacter cloacae isoelectric focusing
-
4.5